Method and device for ultrafiltration during hemodialysis

• US 4,997,570 A
• Filed: 11/03/1989
• Issued: 03/05/1991
• Est. Priority Date: 11/04/1988
• Status: Expired due to Term

• Current Assignee: Fresenius AG (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius AG (Fresenius SE & Co. KGaA)
• Inventors: Polaschegg, Hans-Dietrich
• Primary Examiner(s): JONES, WILLIAM G
• Application Number:
  US07/431,555
• Time in Patent Office: 487 Days
• Field of Search: 210/646, 210/647, 210/739, 210/744, 210/121, 210/123, 210/321.71, 210/321.72-321.81, 210/314, 210/321.65, 210/929, 210/806, 210/470, 210/91, 210/97
• US Class Current: 210/646
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1639 linked by membranes
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: Y10S 210/929 Hemoultrafiltrate volume measurement or control processes

Abstract

A method and a device for ultrafiltration during hemodialysis are described in which ultrafiltrate fluid, before removal from the dialysis circuit, is passed through a balancing device, which is also used as ultrafiltrate pump. For this purpose, a controller controls and actuates inlet, outlet, and dialyzer valves, in such a way that a desired amount of ultrafiltrate, corresponding to the filling volume of a balancing chamber or a multiple thereof, is introduced to the discharge through the balancing chamber. In order to carry out continuous ultrafiltration during hemodialysis, a predetermined amount of air is introduced to the dialysis fluid flow circuit through an air separator and is then pumped off during hemodialysis so that a corresponding amount of ultrafiltrate is obtained.

Claims

1. A method useful in the hemodialysis of blood wherein a dialysis fluid is passed through a dialysis circuit including a dialyzer and ultrafiltrate is removed in an accurately predetermined amount, said method comprising the steps of:

(a) providing a balancing device in the dialysis circuit, the balancing device comprising shut-off valves and balancing chambers; and

(b) removing the ultrafiltrate from the dialysis circuit through a balancing chamber of the balancing device in a controlled manner wherein the dialysis circuit is interrupted between two hemodialysis cycles and the shut-off valves of the balancing device are switched in such a way that at least the ultrafiltrate flows into one of the balancing chambers as fresh dialysis fluid contained therein is transferred into another of the balancing chambers.

2. The method of claim 1 wherein the ultrafiltrate is removed from the dialysis circuit in an amount corresponding to a filling volume of a balancing chamber or a multiple thereof.

3. The method of claim 1 wherein the dialysis circuit is interrupted between the balancing device and the dialyzer for the duration of the removal of the ultrafiltrate while the predetermined amount of ultrafiltrate flows from the dialyzer into one of the balancing chambers.

4. A method useful in the hemodialysis of blood wherein a dialysis fluid is passed through a dialysis circuit including a dialyzer and an ultrafiltrate is removed in an accurately predetermined amount alternately with removal of used dialysis fluid, said method comprising the steps of:

(a) providing a balancing device in the dialysis circuit, the balancing device comprising shut-off valves and balancing chambers;

(b) interrupting the dialysis circuit between the balancing device and the dialyzer while introducing a volume of air corresponding to a filling volume of one of the balancing chambers, or a multiple thereof, into the dialysis circuit;

(c) continuously removing said volume of air from the dialysis circuit during hemodialysis so that a corresponding amount of ultrafiltrate is obtained in the dialysis circuit;

(d) continuously removing the ultrafiltrate from the dialysis circuit through the balancing device in a controlled manner wherein the shut-off valves of the balancing device are switched in such a way that at least the ultrafiltrate flows into one of the balancing chambers as fresh dialysis fluid contained therein is transferred into another of the balancing chambers and used dialysis fluid is removed through the balancing device.

5. The method of claim 4 wherein the air introduced into the dialysis circuit during said interruption is introduced at a rate such that the pressure in said circuit does not substantially increase.

6. The method of claim 4 wherein the air introduced into the dialysis circuit during said interruption is introduced through an air separator.

7. The method of claim 4 wherein the dialysis circuit is interrupted between the dialyzer and an air separator and the volume of air introduced into the dialysis circuit during said interruption is aspirated by a dialysis fluid pump through said air separator.

8. A dialysis circuit device useful for the controlled processing of a dialysis fluid, said device comprising:

a dialyzer;

a balancing device comprising two chambers each of which is subdivided by a movable element, each chamber having an inlet conduit for fresh dialysis fluid and an outlet conduit connected to a fluid discharge port for removing used dialysis fluid;

shut-off valves arranged in the inlet and outlet conduits;

a pump arranged for transporting used dialysis fluid;

an air separator;

a preparation unit for providing fresh dialysis fluid; and

a control unit connected to the shut-off valves comprising means for controlling and switching the shut-off valves so that ultrafiltrate is discharged in a previously determined amount through a chamber of the balancing device to the fluid discharge port said control unit further comprising means for controlling transfer of fresh dialysis fluid from one balancing device chamber to the other balancing device chamber.

9. The device of claim 8 wherein the control unit and shut-off valves comprise means for controlling and switching the shut-off valves such that the discharged amount of ultrafiltrate corresponds to a filling volume of one of the chambers.

10. The device of claim 8 wherein the device further comprises means for detecting a final position of the movable element and the control unit and shut-off valves comprise means for transferring fresh dialysis fluid from one chamber to another chamber during an inflow of at least the ultrafiltrate into the chamber from which said fresh dialysis fluid is transferred.

11. The device of claim 8 further comprising means for introducing air into the air separator and means for removing air from the air separator.

12. The device of claim 8 wherein a bidirectional pump is connected to the air separator.

13. The device of claim 8 further comprising means for limiting the volume of air in the air separator to a volume corresponding to a filling volume of one of the chambers, or a multiple thereof, said limiting means comprising a lower sensor and an upper sensor disposed at said air separator.

14. The device of claim 8 further comprising an analog level meter disposed at the air separator and having a minimum position and a maximum position defining a volume corresponding to a filling volume of one of the chambers, or a multiple thereof.

15. The device of claim 8 further comprising a dialyzer valve and a valve disposed in a dialyzer discharge branch between an outlet of the dialyzer and an inlet of the air separator.