Method and material for prevention of surgical adhesions

• US 5,002,551 A
• Filed: 08/22/1985
• Issued: 03/26/1991
• Est. Priority Date: 08/22/1985
• Status: Expired due to Term

• Current Assignee: Johnson & Johnson Medical Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Medical Incorporated (Johnson & Johnson)
• Inventors: Linsky, Cary B., Cunningham, Timothy J.
• Primary Examiner(s): Cannon, Alan W.
• Application Number:
  US06/768,280
• Time in Patent Office: 2,042 Days
• Field of Search: 623/11, 623/66, 623/1, 623/2, 128/156, 128/334 R, 128/DIG. 8, 536/57, 536/56, 536/80, 536/88, 8/116.1, 424/28, 604/374-376
• US Class Current: 606/151
• CPC Class Codes: A61B 2090/0816 for preventing adhesion
• CPC Class Codes: A61B 90/00 Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges protective face masks A41D13/11; surgeon's or patient's gowns or dresses A41D13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M1/00
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 1/04 Oxycellulose; Hydrocellulose , e.g. microcrystalline cellulose
• CPC Class Codes: D04B 21/16 incorporating synthetic threads
• CPC Class Codes: D10B 2509/08 Hernia repair mesh

Abstract

An absorbable fabric which effectively reduces the incidence of postoperative adhesions when used as a physical barrier at the operative site is a warp knit fabric of oxidized regenerated cellulose or other bioresorbable material. The barrier fabric is particulary characterized by having a density of 8 to 15 mg/cm² and an open area porosity of 12 to 20 percent.

Claims

1. A method for reducing the incidence of postoperative adhesions which comprises positioning as a physical barrier between the site of the surgical activity and neighboring tissue a fabric constructed of a bioresorbable material, said fabric being characterized by having a density of 8.0 to 15 mg/cm² and a porosity of 12 to 20 percent open area.

4. The method of claim 1 wherein said material is selected from the group consisting of oxidized regenerated cellulose and proteinaceous fibers.

5. The method of claim 1 wherein the numerical ratio of said porosity to said density is 1.0 or greater.

6. The method of claim 1 wherein said fabric has a knit or nonwoven construction.

7. The method of claim 1 wherein said fabric has a warp knit construction.

2. A method for reducing the incidence of postoperative adhesions which comprises positioning as a physical barrier between the site of the surgical activity and neighboring tissue a warp knit fabric of oxidized regenerated cellulose, said fabric being characterized by having a density of 8.0 to 15 mg/cm² and a porosity of 12 to 20% open area.

8. The method of claim 2 wherein said fabric is derived from continuous filament bright rayon yarn having a total denier of from about 40 to 80 and containing from 10 to 25 individual filaments.

9. The method of claim 2 wherein said fabric is derived from a 60 denier, 18 filament bright rayon yarn.

10. The method of claim 2 wherein said fabric is a tricot knit fabric.

11. The method of claim 2 wherein said numerical ratio of porosity to density is 1.0 or greater.

12. The method of claim 2 wherein said fabric is derived from continuous filament bright rayon yarn having a total denier of from about 40 to 80 and containing from 10 to 25 individual filaments.

3. A method for reducing the incidence of postoperative adhesions which comprises positioning as a physical barrier between the site of the surgical activity and neighboring tissue a warp knit tricot fabric of oxidized regenerated cellulose, said fabric being characterized by a density of 9 to 13 mg/cm² and an open area porosity of 15 to 19 percent.

13. The method of claim 3 wherein said fabric is derived from a 60 denier, 18 filament bright rayon yarn.

14. The method of claim 3 wherein the numerical ratio of porosity to density is 1.0 or greater.