Calcification mitigation of bioprosthetic implants
First Claim
1. A process for making a calcification-resistant biological material comprising applying to said material a solution comprising an ion selected from the group consisting of ferric ions, stannic ions, or a combination of ferric and stannic ions to impregnate said material with a calcification-mitigating effective amount of said ferric ions, stannic ions, or a combination of ferric and stannic ions, wherein the biological material is tanned prior to said step of applying said solution.
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Accused Products
Abstract
Calcification resistant bioprosthetic implants are made from tanned biological materials, such as porcine heart valves, bovine pericardium, human dura mater or the like, which has been impregnated with a calcification-mitigating effective amount of a ferric and/or stannic salt. The impregnated biological materials and processes are particularly advantageous for the preparation of bioprosthetic heart valves. These implants have been found to be highly resistant to calcification in vivo.
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Citations
18 Claims
- 1. A process for making a calcification-resistant biological material comprising applying to said material a solution comprising an ion selected from the group consisting of ferric ions, stannic ions, or a combination of ferric and stannic ions to impregnate said material with a calcification-mitigating effective amount of said ferric ions, stannic ions, or a combination of ferric and stannic ions, wherein the biological material is tanned prior to said step of applying said solution.
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18. A process for making a calcification-resistant biological material comprising applying to said material a solution comprising an ion selected from the group consisting of ferric ions, stannic ions, or a combination of ferric and stannic ions to impregnate said material with a calcification-mitigating effective amount of said ferric ions, stannic ions, or a combination of ferric and stannic ions, and wherein the solution contains up to about 30% ethanol, up to about 5% formaldehyde, up to about 1% glutaraldehyde, or up to about 30% glycerol,or mixtures thereof.
Specification