Sensor and method for sensing the concentration of a component in a medium

• US 5,006,314 A
• Filed: 06/13/1988
• Issued: 04/09/1991
• Est. Priority Date: 04/18/1986
• Status: Expired due to Term

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: 3M Company
• Inventors: Maxwell, Thomas P., Hacker, Thomas G., Yafuso, Masao, Miller, William W., Gourley, Ted H.
• Primary Examiner(s): Johnston, Jill
• Application Number:
  US07/206,189
• Time in Patent Office: 1,030 Days
• Field of Search: 422/58, 422/68, 422/82.06-82.11, 436/68, 436/165, 128/642, 250/227, 250/227.14, 350/96.29, 356/39, 356/402, 427/2, 156/296
• US Class Current: 422/82.07
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: G01N 2021/6434 Optrodes
• CPC Class Codes: G01N 2021/6439 with indicators, stains, dyes, tags, labels, marks
• CPC Class Codes: G01N 2021/772 Tip coated light guide
• CPC Class Codes: G01N 2021/773 Porous polymer jacket; Polymer matrix with indicator
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G01N 21/80 Indicating pH value
• CPC Class Codes: G01N 21/81 Indicating humidity
• CPC Class Codes: G01N 31/223 for investigating presence of specific gases or aerosols G01N31/221, G01N31/222 take precedence; actuation of fire alarm by presence of smoke or gases G08B17/10

Abstract

An apparatus for sensing the concentration of a component such as oxygen in a medium such as blood. The apparatus includes an elongated signal transmitter and a sensing element at one end thereof. A substantially rigid sleeve is secured around such end to provide a pocket for the sensing element.

Claims

1. An apparatus for sensing the concentration of a component in a medium comprising:

sensor means including at least one indicator for providing a signal which varies in response to the concentration of a component in a medium;

elongated signal means having a distal end at or near which said sensor means is located, said elongated signal means acting to transmit a signal from said sensor means;

sleeve means more rigid than said elongated signal means, said sleeve means being secured to said elongated signal means and extending distally of said distal end of said elongated signal means to at least partially define a pocket in which said sensor means is located, said sleeve means acting to reduce the possibility of relative movement between said sensor means and said distal end of said elongated signal means; and

overcoating means acting to at least partially cover said sensor means.

2. The apparatus of claim 1 wherein said sleeve means is substantially rigid.

3. The apparatus of claim 1 wherein said sleeve means extends distally of said distal end of said elongated signal means a distance in the range of about 0.5 to about 2 times the maximum transverse dimension of said distal end of said elongated signal means.

4. The apparatus of claim 3 wherein said sleeve means is substantially rigid.

5. In a method for measuring the concentration of a component in a medium involving transmitting a signal from a sensor which includes at least one indicator for providing a signal which varies in response to the presence of said component in said medium, the improvement which comprises utilizing the apparatus of claim 4.

6. The apparatus of claim 1 which further comprises adhesive means acting to adhesively secure said sleeve means to said elongated signal means.

7. The apparatus of claim 6 wherein said indicator is an optical indicator and said adhesive means includes additional optical indicator and acts to provide said additional optical indicator to said sensor means.

8. In a method for measuring the concentration of a component in a medium involving transmitting a signal from a sensor which includes at least one indicator for providing a signal which varies in response to the presence of said component in said medium, the improvement which comprises utilizing the apparatus of claim 6.

9. The apparatus of claim 1 wherein said elongated signal means is an optical fiber.

10. The apparatus of claim 9 wherein said optical fiber acts to transmit signals to and from said sensor means.

11. The apparatus of claim 10 which further comprises a light source for transmitting light signals through said optical fiber to said sensor means and a light receiver for receiving light signals from said sensor means through said optical fiber.

12. The apparatus of claim 1 wherein said sleeve means further acts to increase the apparent stiffness of at least one of said distal portion of said elongated signal means and said sensor means.

13. The apparatus of claim 12 wherein said sensor means further includes a component permeable, polymeric matrix.

14. The apparatus of claim 1 wherein said sleeve means is made of glass.

15. In a method for measuring the concentration of a component in a medium involving transmitting a signal from a sensor which includes at least one indicator for providing a signal which varies in response to the presence of said component in said medium, the improvement which comprises utilizing the apparatus of claim 14.

16. The apparatus of claim 1 wherein said indicator is an optical indicator.

17. The apparatus of claim 16 wherein said optical indicator is selected from the group consisting of fluorescence indicators.

18. The apparatus of claim 1 wherein said elongated signal means is further capable of delivering a source signal to said sensor means.

19. The apparatus of claim 18 wherein said elongated signal means is an optical fiber.

20. The apparatus of claim 1 wherein said pocket is substantially filled with component permeable material.

21. In a method for measuring the concentration of a component in a medium involving transmitting a signal from a sensor which includes at least one indicator for providing a signal which varies in response to the presence of said component in said medium, the improvement which comprises utilizing the apparatus of claim 1.

22. The method of claim 21 wherein said medium is an aqueous medium.

23. The method of claim 21 wherein said medium is blood.

24. The method of claim 21 wherein said component is selected from the group consisting of oxygen, carbon dioxide, hydrogen ions, electrolytes and glucose.

25. An apparatus for sensing the concentration of a component in a medium comprising:

sensor means including at least one optical indicator for providing a signal which varies in response to the concentration of a component in a medium;

elongated signal means having a distal end at or near which said sensor means is located, said elongated signal means acting to transmit a signal from said sensor means;

sleeve means more rigid than said elongated signal means, said sleeve means being secured to said elongated signal means and extending distally of said distal end of said elongated signal means to at least partially define a pocket in which said sensor means is located, said sleeve means extending around the entire circumference of at least a portion of said sensor means, said sleeve means acting to reduce the possibility of relative movement between said sensor means and said distal end of said elongated signal means; and

adhesive means acting to adhesively secure said sleeve means to said elongated signal means, said adhesive means including additional optical indicator and acting to provide said additional optical indicator to said sensor means.

26. The apparatus of claim 25 which further comprises overcoating means acting to at least partially cover said sensor means.

27. The apparatus of claim 26 wherein said overcoating means comprises a medium insoluble, component permeable polymeric material and an effective amount of an opaque agent.

28. The apparatus of claim 26 wherein said indicator is a fluorescence indicator and said overcoating means comprises a water insoluble, component permeable, cross-linked cellulosic material.

29. An apparatus for sensing the concentration of a component in a medium comprising:

an optical fiber having a distal end;

a sleeve member more rigid than said optical fiber, said sleeve member being secured to said optical fiber and extending distally of said distal end whereby said distal end and said sleeve member at least partially define a pocket;

an optical indicator in said pocket for providing a signal which varies in response to the concentration of the component in the medium, said sleeve member extending around the entire circumference of at least a portion of said optical indicator, and said sleeve member acting to reduce the possibility of relative movement between said distal end of said optical fiber and said optical indicator; and

overcoating means acting to at least partially cover said optical indicator.

30. The apparatus of claim 29 including an annular layer of adhesive on said distal portion of said optical fiber for securing said sleeve to said optical fiber, said annular layer terminating proximally of said distal end of said optical fiber.

31. The apparatus of claim 30 wherein said annular layer of adhesive cooperates with said optical fiber and said sleeve member to at least partially define said pocket, said pocket has an annular region surrounding said optical fiber closely adjacent said distal end of said optical fiber and at least some of said optical indicator is in said annular layer.

32. The apparatus of claim 29 wherein said sleeve member is substantially rigid.

33. The apparatus of claim 29 wherein said sleeve means extends distally of said distal end of said elongated signal means a distance in the range of about 0.5 to about 2 times the maximum transverse dimension of said distal end of said elongated signal means.

34. The apparatus of claim 29 wherein said pocket is substantially filled with component permeable material.

35. The apparatus of claim 29 wherein said optical fiber acts to transmit signals to and from said optical indicator.

36. In a method for measuring the concentration of a component in a medium involving transmitting a signal from a sensor which includes at least one indicator for providing a signal which varies in response to the presence of said component in said medium, the improvement which comprises utilizing the apparatus of claim 29.

37. An apparatus for sensing the concentration of a component in a medium comprising:

elongated signal means having a distal end;

sleeve means secured to said elongated signal means and extending distally of said distal end whereby said distal end and said sleeve means at least partially define a pocket which is substantially filled with component permeable material;

sensor means in said pocket for providing a signal which varies in response to the concentration of the component in the medium, said sleeve means extending around the entire circumference of at least a portion of said sensor means, and said sleeve means acting to reduce the possibility of relative movement between said distal end of said elongated signal means and said sensor means; and

overcoating means acting to at least partially cover said sensor means.

38. The apparatus of claim 37 wherein said elongated signal means is a single optical fiber and said distal end of said optical fiber is located in said sleeve means.

39. The apparatus of claim 37 wherein said elongated signal means comprises an optical fiber, said sleeve means comprises a sleeve member, and said sensor means comprises an optical indicator.

40. In a method for measuring the concentration of a component in a medium involving transmitting a signal from a sensor which includes at least one indicator for providing a signal which varies in response to the presence of said component in said medium, the improvement which comprises utilizing the apparatus of claim 37.

41. A method for producing an apparatus for sensing the concentration of a component in a medium, comprising the steps of:

securing a sleeve member to an optical fiber having a distal end so that said sleeve member extends distally of said distal end and so that said sleeve member and said distal end at least partially define a pocket;

placing an optical indicator in said pocket, said sleeve member extending around the entire circumference of at least a portion of said optical indicator; and

placing an overcoating adjacent at least a portion of said optical indicator in said pocket.