Drug delivery catheter

• US 5,007,897 A
• Filed: 05/30/1989
• Issued: 04/16/1991
• Est. Priority Date: 05/30/1989
• Status: Expired due to Fees

• Current Assignee: Irvin M. Kalb, Michael J Ram
• Original Assignee: Irvin M. Kalb, Michael J Ram
• Inventors: Ram, Michael J., Kalb, Irvin M.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): Gutowski, Anthony
• Application Number:
  US07/358,083
• Time in Patent Office: 686 Days
• Field of Search: 604/840.1-892.1, 604/27, 604/41, 604/43, 604/45, 604/246, 604/265, 604/93, 604/94, 604/96, 604/104, 604/284, 604/285, 604/286, 604/280, 604/278, 606/192, 606/193, 600/29-31, 128/DIG. 25, 128/918
• US Class Current: 604/43
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 25/0043 characterised by structural features
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

The invention comprises a system for the long term continuous delivery of medication to hollow body organs. It is particularly suited for the deivery of chemotherapy drugs to lesions in the walls of those organs. The invention, specially designed for the treatment of the prostate gland, comprises a urinary drainage catheter which has an additional lumen within the wall thereof, said lumen proximate end connected to a space external of the catheter wall enclosed by a porous membrane. The distal end of the lumen, which is external to the penis when the catheter is positioned in the body, has a valved end for introduction of liquid medication therethrough. In use, the catheter is placed within the urethra, with the porous membrane portion adjacent the prostatic ducts. Medication introduced through said valve is transmitted along the lumen into the space between the catheter and the porous membrane, through the membrane and into contact with the prostatic ducts.

Claims

1. A system for the controlled, continuous delivery over an extended period of time of a drug containing fluid to the prostate comprising a catheter including an elongated tubular member having an external distal end and a proximal end for placement into the urinary bladder through the male urethra, expandable means adjacent the proximal end to retain the catheter in sealing abutment against the neck of the bladder, an expandable porous membrane bag integral with and spaced from the outer surface of said tubular member, distal to the expandable means for retention of the catheter, a drug lumen within said tubular wall connecting the space between the outer surface of said tubular member and the membrane bag with a valve mounted on the distal end of the lumen for the introduction of the drug to the prostate, said membrane positioned so that upon placement of the catheter the membrane bag is adjacent the prostate ducts, the catheter having a lumen within the wall of said tubular member connecting the expandable retention means with a valve on the distal end of said tubular member the elongated tubular member also having a drainage lumen therein extending from the proximal end only partially along the length of the elongated member, the expansion lumen and the drug lumen for a portion of their length being enclosed within tubular members having semicircular crosssections and opposing flat surfaces.

2. The catheter of claim 1 further having a sheath integral with said tubular member distal end, said sheath being condom shaped for leakproof covering of at least the meatus of the penis when the catheter is positioned in the urethra.

3. The catheter of claim 2 wherein said means for retention is an inflatable balloon.

4. The catheter of claim 1 further having the space between the porous membrane and the tubular member at least partially filled by an open pore compressible sponge like material.