Pharmaceutical compositions with controlled release, and a method for their preparation
First Claim
1. Pharmaceutical compositions comprising a microporous support having pores of an average diameter of between 5 and 150 nm, a surface area of between 30 and 600 m2 /g, and a particle diameter of less than 200 microns, said microporous support being selected from the group consisting of silica, silicates, zeolites, alumina, activated carbon and a microporous polymer, said microporous support having a pharmaceutically active substance selected from the group consisting of antihypertensive, antiinflammatory, antianxiety, antidepressive, corticosteroids and antibacterial medicaments distributed within the support pores in crystalline form, the crystal dimensions being in the nanometer range.
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Accused Products
Abstract
Pharmaceutical compositions including a microporous support and an active substance incorporated therein, the incorporation of the active substance being effected by adding the microporous support to a solution of the active substance, stirring the mixture obtained for at least 70 hours at ambient temperature and finally evaporating the solvent slowly.
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Citations
13 Claims
- 1. Pharmaceutical compositions comprising a microporous support having pores of an average diameter of between 5 and 150 nm, a surface area of between 30 and 600 m2 /g, and a particle diameter of less than 200 microns, said microporous support being selected from the group consisting of silica, silicates, zeolites, alumina, activated carbon and a microporous polymer, said microporous support having a pharmaceutically active substance selected from the group consisting of antihypertensive, antiinflammatory, antianxiety, antidepressive, corticosteroids and antibacterial medicaments distributed within the support pores in crystalline form, the crystal dimensions being in the nanometer range.
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7. A method for preparing pharmaceutical compositions, comprising adding a microporous support, having pores of an average diameter of between 5 and 150 nm, a surface area of between 30 and 600 m2 /g, and a particle diameter of less than 200 microns, and being selected from the group consisting of silica, silicates, zeolites, alumina, activated carbon and a microporous polymer, to a solution of a pharmaceutically active substance selected from the group consisting of antihypertensive, antiinflammatory, antianxiety, antidepressive, corticosteroids and antibacterial medicaments, stirring at ambient temperature for at least 70 hours, then slowly evaporating the solvent at a temperature of 10°
- -20°
C. less than the solution boiling point in a pressure of between 500 and 760 mmHg. - View Dependent Claims (8, 9, 10, 11, 12, 13)
- -20°
Specification