Fiber optic catheter system with fluorometric sensor and integral flexure compensation
First Claim
1. A fluorometric sensor for measuring oxygen concentration in a body fluid comprising:
- a means for emitting excited light in which at least one wavelength emitted is in the upper visible-long ultraviolet light spectrum;
an elongated fiber-optic equipped catheter having a distally positioned fluorometric sensor comprising a silicone copolymer matrix and a fluophor formed by dissolving into a silicone copolymer an amount of about 0.1% to 3% by weight of the fluophor selected from the group consisting of parylene dibutyrate, tris (4,7-diphenyl-1,10 phenanthroline) ruthenium II, tris (disulphonated 4,7-diphenyl-1,10 phenanthroline) ruthenium II, and tris (bipyridine) ruthenium II, in order for the fluophor to emit a fluorescent signal in response to the excited light transmitted from a proximal end of the catheter and the fluorescent signal having an intensity that is quenched by oxygen permeating from the body fluid into the silicone copolymer matrix, and wherein the silicone copolymer is selected from the group consisting of silicone polycarbonate copolymer and silicone polystyrene copolymer; and
means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
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Abstract
A sensor for measuring fluid concentrations or the temperature of body. A fiber-optic catheter having a fluorometric sensor attached at a distal end is excited by a light source outside the body. The sensor fluoresces with an intensity or with a lifetime related to the concentration of the fluid or the temperature. The catheter has one light pipe for exciting the sensor and a second light pipe for generating a reference signal to calibrate signals from the fluorometric sensor. One embodiment has two sensors that fluoresce with different intensities and lifetimes to simultaneously give information about both the temperature and the fluid concentration.
86 Citations
3 Claims
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1. A fluorometric sensor for measuring oxygen concentration in a body fluid comprising:
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a means for emitting excited light in which at least one wavelength emitted is in the upper visible-long ultraviolet light spectrum; an elongated fiber-optic equipped catheter having a distally positioned fluorometric sensor comprising a silicone copolymer matrix and a fluophor formed by dissolving into a silicone copolymer an amount of about 0.1% to 3% by weight of the fluophor selected from the group consisting of parylene dibutyrate, tris (4,7-diphenyl-1,10 phenanthroline) ruthenium II, tris (disulphonated 4,7-diphenyl-1,10 phenanthroline) ruthenium II, and tris (bipyridine) ruthenium II, in order for the fluophor to emit a fluorescent signal in response to the excited light transmitted from a proximal end of the catheter and the fluorescent signal having an intensity that is quenched by oxygen permeating from the body fluid into the silicone copolymer matrix, and wherein the silicone copolymer is selected from the group consisting of silicone polycarbonate copolymer and silicone polystyrene copolymer; and means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
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2. A fluorometric sensor for measuring oxygen concentration in a body fluid comprising:
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light excitation means emitting excitation light having at least one wavelength in the upper visible-long ultraviolet light spectrum; an elongated fiber-optic equipped catheter including a distally positioned fluorometric sensor comprising a silicone polycarbonate copolymer and an amount of about 0.5% to 1% by weight of a fluophor dissolved into the silicone polycarbonate copolymer that emits a fluorescent signal in response to the excitation light transmitted from a proximal end of the catheter and having an intensity that is quenched by oxygen permeating from the body fluid into the silicone polycarbonate copolymer, and wherein the fluophor is selected from the group consisting of parylene dibutyrate, tris(4,7-diphenyl-1,10 phenanthroline) ruthenium II, tris (disulphonated 4,7-diphenyl-1,10 phenanthroline) ruthenium II, and tris (bipyridine) ruthenium II; and means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
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3. A fluorometric sensor for measuring oxygen concentration in a body fluid comprising:
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light excitation means emitting excitation light having at least one wavelength in the upper visible-long ultraviolet light spectrum; an elongated fiber-optic equipped catheter including a distally positioned fluorometric sensor comprising a silicone-polystyrene copolymer and an amount of about 0.1% to 3% by weight of a fluophor dissolved into the silicone polystyrene copolymer that emits a fluorescent signal in response to the excitation light transmitted from a proximal end of the catheter and having an intensity that is quenched by oxygen permeating from the body fluid into the silicone polystyrene, and wherein the fluophor is selected from the group consisting of parylene dibutyrate, tris (4,7-diphenyl 1,10 phenanthroline) ruthenium II, tris disulphonated 4,7 diphenyl 1,10 phenanthroline ruthenium II, and tris (bipyridine) ruthenium II; and means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
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Specification