Fluid injector

• US 5,012,845 A
• Filed: 08/18/1988
• Issued: 05/07/1991
• Est. Priority Date: 08/18/1988
• Status: Expired due to Term

• Current Assignee: Varian Incorporated (Agilent Technologies, Inc.)
• Original Assignee: Dynatech Precision Sampling Corp (Siemens AG)
• Inventors: Averette, Julius P.
• Primary Examiner(s): Recla, Henry J.
• Assistant Examiner(s): JACYNA, J CASIMER
• Application Number:
  US07/233,354
• Time in Patent Office: 992 Days
• Field of Search: 73/863.81, 73/864.81-864.87, 73/864.21, 73/864.22, 73/864.24, 73/864.16, 73/864.17, 73/864.18, 73/864.11 , 73/864.13, 73/863.84, 73/863.83, 141/27, 141/25, 141/65, 141/130, 141/66, 141/329, 141/330, 422/63, 422/103, 222/400.7, 222/400.8, 604/140, 604/147, 604/155, 604/411, 604/414
• US Class Current: 141/329
• CPC Class Codes: G01N 35/1079 with means for piercing stoppers or septums

Abstract

An automatic fluid injector, useful for the injection of preselected small, accurately measured quantities of fluid specimens into, e.g., an analytical instrument, particularly a purge and trap analyzer. The injector includes generally a syringe, or syringe assembly, inclusive of a barrel into which a fluid specimen can be loaded, a plunger for the displacement of the fluid specimen from said barrel via the dispensing end thereof into the analyzer, and a probe integral therewith for the pick up of the fluid specimen for filling the barrel of the syringe. The combination further includes a magazine for transporting one or more fluid specimen-containing septum sealed vials for pick up of a fluid specimen therefrom by the probe portion of the syringe assembly for delivery to the barrel of the syringe. It thus relates to improvements in a fluid injection apparatus, especially to the combination of a syringe and injector feed assembly, and further combination including a tubular valve assembly which provide a mechanism for delivery of a fluid specimen to an analytical instrument, and purge mechanism.

Claims

1. In apparatus useful for the pick up of a fluid specimen from a fluid specimen-containing septum sealed vial carried by a magazine, and injection of preselected quantities of the fluid specimen into an analytical instrument, the combination comprising

a syringe assembly which includes

a barrel,

a plunger rod reciprocably mounted in one end of the barrel,

a pair of concentric hollow needles of different diameters, an outer larger diameter needle containing a side wall opening communicating with the axial opening therethrough, mounted in the end of the barrel opposite the plunger to form an annulus between the external wall surface of said inside smaller diameter needle and the inside wall surface of said larger diameter needle,

means for reciprocation of the plunger rod within the barrel of the syringe,

means for the reciprocal movement of the syringe barrel,

a tubular block valve the tubular opening through which said concentric pair of needles can be projected into a vial carried by said magazine and positioned in-line therewith, said valve further including a pair of lateral channels communicated with said tubular opening, the first of said lateral channels fluidly communicating with a pressurized gas, the second of said lateral channels adapted to be connected to said analytical instrument,

whereby, when the dispensing end of the pair of needles is projected through the septum into a vial and an end of the smaller diameter needle immersed in a fluid specimen, gas is passed via the side wall opening of the large diameter needle and the first lateral opening of said block valve via the needle annulus to pressurize the fluid contents of the vial and drive fluid specimen into the axial opening of the small diameter needle, and on retraction of the plunger rod into the syringe barrel, and on the closure of said first lateral block valve opening and opening of the second lateral block valve opening, the fluid specimen can be displaced from the syringe barrel and expressed via said second lateral block valve opening to the analytical instrument.

2. The apparatus of claim 1 wherein the syringe and block valve are mounted on the vertical wall of a housing, and the means for vertical reciprocation of the plunger rod and syringe body are located on the opposite side of the wall on which the syringe and block valve are located, while the block valve is maintained in fixed position on the side of the wall whereon the syringe is mounted.

3. The apparatus of claim 1 wherein means for reciprocation of the plunger rod and syringe barrel are comprised of a vertical frame support,

a motor driven sample syringe plunger drive located on said vertical frame support operatively connected to said plunger rod for vertical reciprocation of same within the syringe barrel,

a motor driven syringe mount plate located on said vertical frame support operatively connected to said syringe for vertical reciprocal movement of said syringe,

and stop means located on said frame support which define the upper and lower limits of vertical movement, respectively, in the operation of the syringe.

4. The apparatus of claim 3 wherein the plunger drive and syringe mount plate are each affixed to a threaded vertical shaft located upon the support frame, and each threaded shaft is rotated independently in either direction by a linear motor mounted upon the frame to move the plunger drive and syringe mount plate, respectively, upwardly and downwardly to project or withdraw the plunger rod within the syringe barrel, and to move the syringe downwardly to pick up fluid specimen from a vial for loading into the syringe barrel, or upwardly to discharge the contents of the syringe barrel.

5. In a fluid apparatus for the injection of preselected quantities of a fluid specimen into an analytical instrument wherein there is included the combination of

(A) a syringe constituted of

a barrel into which a fluid specimen can be loaded, and

a plunger rod reciprocally mounted in one end of the barrel for opening the barrel for receipt of fluid specimen, and for displacement of fluid specimen from the barrel,

(B) an injector feed assembly constituted of

a pair of concentrically mounted needles of different diameters, each provided with an axial opening therethrough,

an outer larger diameter needle containing a side wall opening communicating with the axial opening therethrough, and

an inner needle of sufficiently small diameter to form an annulus between the external surface of said inner needle and the internal surface of said outer tubular needle, and

(C) a magazine for transporting one or more fluid specimen-containing septum sealed vials, and serially positioning a vial for the pickup of a fluid specimen therefrom via projection of the dispensing end of said concentric pair of needles of said injector feed assembly (B) through the septum of a vial, gas being passed via the side wall opening of the large diameter needle through the needle annulus to pressurize the fluid contents of the vial to drive fluid specimen from the vial through the axial opening of the small diameter needle for transfer to the barrel of the syringe,

the improvement wherein

an end of the outer larger diameter needle of the injector feed assembly (B) containing the side wall opening is mounted directly within the end of the barrel opposite that in which the plunger is mounted, the syringe (A) and injector feed assembly (B) thus forming a unitary assembly, and

(D) a tubular block valve through the tubular opening of which said concentric pair of needles can be projected into a vial carried by said magazine and positioned in-line therewith, said valve further including a pair of lateral channels, the first of said lateral channels fluidly communicating with a pressurized gas, the second of said lateral channels adapted to be connected to said analytical instrument, such that when the concentric pair of needles of said feed injector assembly (B) is projected through the tubular opening, through a vial septum and into a vial carried by the magazine, and an end of the smaller diameter needle immersed in a fluid specimen, gas can be passed via the first lateral channel of said block valve, the side wall opening of the large diameter needle, and via the needle annulus to pressurize the fluid contents of the vial and drive fluid specimen into the axial opening of the small diameter needle, and on retraction of the plunger rod into the syringe barrel, and on closure of said first lateral block valve channel and opening of the second lateral block channel, the fluid specimen can be displaced from the syringe barrel and expressed via said second lateral block valve channel to the analytical instrument.

6. The apparatus of claim 5 wherein the end of the syringe barrel to which the outer larger diameter needle of the injector feed assembly (B) is directly attached contains a tubular packing, a lateral opening in communication with the tubular opening of said packing, and the axial opening of the smaller diameter needle is in communication with the tubular opening through said packing

whereby, with the forward end of the plunger rod closing the tubular opening within said packing, an initial portion of the fluid specimen from a vial which often contains foam, or bubbles, can be expressed via said lateral opening of the packing to waste, the lateral opening then closed, and the plunger rod retracted to load fluid specimen into the syringe barrel.

7. The apparatus of claim 5 wherein the syringe and block valve are mounted on the vertical wall of a housing, and drive means are provided to vertically independently reciprocate the plunger rod portion of the syringe, while the block valve is maintained in fixed position upon the wall.

8. The apparatus of claim 7 wherein the drive means is comprised of a vertical frame support,

a motor driven sample syringe plunger drive located on said vertical frame support operatively connected to said plunger rod for vertical reciprocation of same within the syringe barrel,

a motor driven syringe mount plate located on said vertical frame support operatively connected to the body of said syringe for vertical reciprocal movement of said syringe,

and stop means which define the upper and lower limits of vertical movement, respectively, in the operation of the syringe.

9. The apparatus of claim 8 wherein the plunger drive and syringe mount plate are each affixed to a threaded vertical shaft located upon the support frame, and each threaded shaft is rotated independently in either direction by a linear motor mounted upon the frame to move the plunger drive and syringe mount plate, respectively, upwardly and downwardly to project or withdraw the plunger rod within the syringe barrel, and to move the syringe downwardly to pick up fluid specimen from a vial for loading into the syringe barrel, and upwardly to discharge the contents of the syringe barrel.