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Integral multilayer analytical element for analysis of albumin

  • US 5,013,527 A
  • Filed: 08/19/1988
  • Issued: 05/07/1991
  • Est. Priority Date: 08/20/1987
  • Status: Expired due to Term
First Claim
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1. In an integral multilayer analytical element for the analysis of albumin in a sample containing interfering protein having, in this order, a porous spreading layer, at least one hydrophilic polymer binder layer, and a light-transmissive, water-impermeable support layer, wherein one surface of this spreading layer faces the support layer and the other surface of the spreading layer faces away from the support layer and the support layer contains an indicator compound capable of binding to albumin and the interfering protein to produce a color change,the improvement which comprises said spreading layer containing a pH buffer and said indicator in the spreading layer being dispersed in a hydrophilic polymer or a mixture of a hydrophilic polymer and a hydrophobic polymer, such that the color change due to albumin binding occurs substantially towards the surface of the spreading layer facing the support layer and the color change due to the interfering protein occurs substantially towards the surface facing away from the support layer.

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