Unpleasant taste masking compositions and methods for preparing same

• US 5,013,716 A
• Filed: 10/28/1988
• Issued: 05/07/1991
• Est. Priority Date: 10/28/1988
• Status: Expired due to Term

• Current Assignee: McNeil-PPC Incorporated (Johnson & Johnson)
• Original Assignee: Warner-Lambert Company (Pfizer Inc.)
• Inventors: Cherukuri, Subraman R., Wong, Lucy L., Faust, Steven M.
• Primary Examiner(s): Rollins, John W.
• Application Number:
  US07/264,281
• Time in Patent Office: 921 Days
• Field of Search: 426/548, 426/648, 426/650, 426/651, 426/656, 426/658, 426/660, 424/439, 424/440, 424/441, 424/48, 514/2, 514/53, 514/54, 536/18.4, 536/4.1, 530/801, 524/819, 524/824, 524/225, 524/853, 524/855, 524/867
• US Class Current: 514/23
• CPC Class Codes: A23G 4/06 characterised by the composition containing organic or inorganic compounds
• CPC Class Codes: A23G 4/10 characterised by the carbohydrates used, e.g. polysaccharides containing dairy products A23G4/16
• CPC Class Codes: A23G 4/126 containing vitamins, antibiotics
• CPC Class Codes: A23L 27/37 Halogenated sugars

Abstract

The present invention pertains to an unpleasant taste masking composition which comprises a flavoring agent having a bitter taste or unpleasant off-note and a sufficient amount of a non-bitter intense sweetener to nullify the taste or off-note of the flavoring agent. The unpleasant taste masking composition may be used in ingestible products such as hard and soft confections, chewing gum compositions and the like. The present invention also pertains to a method for preparing the unpleasant taste masking compositions and the ingestible products in which they may be used.

Claims

1. An unpleasant taste masking composition which comprises a medicament drug having a bitter taste or unpleasant off-note and a chlorodeoxysugar derivative selected from the group consisting of chlorodeoxysucrose derivatives and chlorodeoxygalactosucrose derivaties and mixtures thereof in an amount from about 0.001% to about 5.0%, by weight to nullify the taste or unpleasant off-note of the medicament drug.

2. The composition of claim 1, wherein the chlorodeoxysugar derivative is 4,1'"'"',6'"'"'-trichloro-4,1'"'"',6'"'"'-trideoxygalactosucrose.

3. The composition of claim 1, wherein the medicament drug having a bitter taste or unpleasant off-note is selected from the group of medicament drugs consisting of analgesics, antiasmatics, antitussives, antihistamines, antinauseants, decongestants, alkaloids, laxatives, anticholesterolemic and antiliped agents, appetite suppressants, central nervous system stimulants, expectorants, anti-inflammatory agents, nutritional supplements and mixtures thereof.

4. The composition of claim 1, wherein the chlorodeoxysugar derivative is present in an amount from about 0.02% to about 1.0%, by weight of the composition.

5. The composition of claim 4 wherein the chlorodeoxysugar derivative is present in an amount from about 0.05% to about 0.5% by weight of the composition.

6. The composition of claim 1, wherein the medicament drug having a bitter taste or unpleasant off-note is present in an amount from about 0.0001% to about 5.0%, by weight of the composition.

14. The confectionery composition of claim 3, wherein the chlorodeoxysugar derivative is 4,1'"'"',6'"'"'-trichloro-4,1'"'"',6'"'"'-trideoxygalactosucrose.

7. A chewing gum composition which comprises a chewing gum base and an effective amount of an unpleasant taste masking composition wherein the unpleasant taste masking composition comprises a medicament drug having a bitter taste or unpleasant off-note and a chlorodeoxysugar derivative selected from the group consisting of chlorodeoxysucrose derivatives and chlorodeoxygalactosucrose derivatives and mixtures thereof in an amount from about 0.001% to about 5.0%, by weight to nullify the taste or unpleasant off-note of the medicament drug.

8. The chewing gum composition of claim 7, wherein the chloroeoxysugar derivative is 4,1'"'"', 6'"'"', -trichloro-4,1'"'"',6'"'"'-trideoxygalactosucrose.

9. The chewing gum composition of claim 7, wherein the medicament drug having a bitter taste or unplesant off-note is selected from the group of medicament drugs consisting of analgesics, antiasmatics, antitussives, antihistamines, antinauseants, decongestants, alkaloids, laxatives, anticholesterolemic and antiliped agents, appetite suppressants, central nervous system stimulants, expectorants, anti-inflammatory agents, nutritional supplements and mixtures thereof.

10. The chewing gum composition of claim 7, wherein the chlorodeoxysugar derivative is present in ana mount from about 0.02% to about 1.0%, by weight of the composition.

11. The chewing gum composition of claim 10, wherein the chlorodeoxysugar derivative is present in an amount from about 0.05% to about 0.5% by weight of the composition.

12. A chewing gum composition which comprises a chewing gum base and an effective amount of an unpleasant taste masking composition wherein the unpleasant taste masking composition comprises a medicament drug 4,1'"'"',6'"'"'-trichloro-4,1'"'"',6'"'"'-trideoxygalactosucrose in an amount of from about 0.001% to about 5.0%, by weight to nullify the bitter taste or unpleasant off-note of the medicament drug.

13. A confectionery composition which comprises a confectionery base and an effective amount of an unpleasant taste masking composition wherein the unpleasant taste masking composition comprises a medicament drug having a bitter gtaste or unpleasant off-note and a chlorodeoxysugar derivative selected from the group consisting of chlorodeoxysucrose derivatives and chlorodeoxygalactosucrose derivatives and mixtures thereof in an amount from about 0.001% to about 5.0%, by weight to nullify the taste or unpleasant off-note of the medicament drug.

15. The confectionery composition of claim 13, wherein the medicament drug having a bitter taste or unpleasant off-note is selected from the medicament drugs consisting of analgesics, antiasmatics, antitussives, antihistamines, antinauseants, decongestants, alkaloids, laxatives, anticholesterolemic and antilipid agents, appetite suppressants, central nervous system stimulants, expectorants, anti-inflammatory agents, nutritional supplements and mixtures thereof.

16. The confectionery composition of claim 13, wherein the chlorodeoxysugar derivative is present in an amount from about 0.02% to about 1.0%, by weight of the composition.

17. The confectionery composition of claim 16, wherein the chlorodeoxysugar derivative is present in an amount from about 0.05% to about 0.5%, by weight of the composition.

18. A confectionery composition which comprises a confectionery base and an effective amount of an unpleasant taste masking composition wherein the unpleasant taste masking composition comprises a medicament drug and 4,1'"'"',6'"'"'-trichloro-4,1'"'"',6'"'"'-trideoxygalactosucrose in an amount of from about 0.001% to about 5%, by weight to nullify the bitter taste or unpleasant off-note of the medicament drug.

19. A pharmaceutical ingestible composition which comprises a pharmaceutically acceptable carrier and a therapeutically effective amount of an unpleasant taste masking composition wherein the unpleasant taste masking composition comprises a medicament drug having a bitter taste or unpleasant off-note and a chlorodeoxysugar derivative selected from the group consisting of chlorodeoxysucrose derivatives and chlorodeoxygalactosucrose derivatives and mixtures thereof in an amount of from about 0.001% to about 5.0%, by weight to nullify the taste or off-note of the medicament drug.

20. A method for preparing an unplesant taste masking composition comprising a medicament drug having a bitter taste or unpleasant off-note which comprises:

admixing the medicament drug having a bitter taste or unpleasant off-note and a chlorodeoxysugar derivative selected from the group consisting of chlorodeoxysucrose derivaties and chlorodeoxygalactosucrose derivatives and mixtures thereof in an amount of from about 0.001% to about 5.0%, by weight to nullify the taste or off-note of the medicament drug.

21. The method of claim 20, wherein the medicinal agent having a bitter taste or unpleasant off-note is present in an amount from about 0.0001% to about 5.0%, by weight of the composition.

22. The method of claim 21, wherein the medicinal agent having a bitter taste or unpleasant off-note is present in an amount from about 1.0% to about 3.0% and the chlorodeoxysugar derivative is present in an amount from about 0.02% to about 1.0%, by weight of the composition.

23. The method of claim 22, wherein the medicinal agent having a bitter taste or unpleasant off-note is present in an amount from about 1.2% to about 2.5% and the chlorodeoxysugar derivative is present in an amount from about 0.05% to about 0.5%, by weight of the composition.

24. The method of claim 22, wherein the chlorodeoxysugar derivative is 4,1'"'"',6'"'"'-trichloro-4,1'"'"',6'"'"'-trideoxygalactosucrose.

25. The method of claim 20, wherein the medicament drug having a bitter taste or unpleasant off-note is selected from the group of medicament drugs consisting of analgesics, antiasmatics, antitussives, antihistamines, antinauseants, decongestants, alkaloids, laxatives, anticholesterolemic and antilipid agents, appetite suppressants, central nervous system stimulants, expectorants, anti-inflammatory agents, nutritional supplements and mixtures thereof.

26. A method for sweetening ingestible compositions which comprises adding to the ingestible composition an effective amount of an unpleasant taste masking composition wherein the unpleasant taste masking composition comprises a medicament drug having a bitter taste or unpleasant off-note and a chlorodeoxysugar derivative selected from the group consisting of chlorodeoxysucrose derivatives and chlorodeoxygalactosucrose derivatives and mixtures thereof in an amount of from about 0.001% to about 5.0%, by weight to nullify the bitter taste or off-note of the medicament drug.

27. The method of claim 26, wherein the medicament drug having a bitter taste or unpleasant off-note is present in an amount from about 0.0001% to about 5.0% by weight of the composition.

28. The method of claim 27, wherein the medicament drug having a bitter taste or unpleasant off-note is present in an amount from about 1.0% to about 3.0% and the chlorodeoxysugar derivative is present in an amount from about 0.02% to about 1.0%, by weight of the composition.

29. The method of claim 28, wherein the medicament drug having a bitter aftertaste or unpleasant off-note is present in an amount from about 1.2% to about 2.5% and the chlorodeoxysugar derivative is present in an amount from about 0.05% to about 0.5%, by weight of the composition.

30. The method of claim 26, wherein the chlorodeoxysugar derivative is 4,1'"'"',6'"'"'-trichloro-4,1'"'"',6'"'"'-trideoxygalactosucrose.

31. The method of claim 26, wherein the medicament drug having a bitter taste or unpleasant off-note is selected from the group of medicament drugs consisting of analgesics antiasmatics, antitussives, antihistamines, antinauseants, decongestants, alkaloids, laxatives, anticholesterolemic and antilipid agents, appetite suppressants, central nervous system stimulants, expectorants, anti-inflammatory agents, nutritional supplements and mixtures thereof.