Rate responsive cardiac pacemaker

• US 5,014,703 A
• Filed: 04/30/1990
• Issued: 05/14/1991
• Est. Priority Date: 09/12/1986
• Status: Expired due to Term

• Current Assignee: Advanced Medical Optics Incorporated (Johnson & Johnson)
• Original Assignee: Intermedics Incorporated (Boston Scientific Corporation)
• Inventors: Alt, Eckhard
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/516,812
• Time in Patent Office: 379 Days
• Field of Search: 128/419 PG, 128/419 P
• US Class Current: 607/19
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

An activity-based variable rate pacemaker senses motion in a preselected low frequency range to detect physical activity of the patient and produce an electrical signal having amplitude maxima and minima representative of the speed and intensity of the physical activity. The electrical signal is selectively limited to appreciable amplitude values for detected physical activity which is related to true physical exercise by the patient, in contrast to detected physical activity which is related to internal and external disturbances on the patient. The amplitude maxima and minima of the selectively limited signal are detected in successive equal intervals of time, the results obtained for consecutive blocks of time each containing the same number of successive equal intervals of time are compared to determine whether the physical exercise is more vigorous or less vigorous than that determined for a predetermined number of immediately preceding blocks, and the pacing rate is adjusted accordingly. The amplitude maxima and minima are sampled at a relatively low rate to conserve energy, and the time intervals are about 300 milliseconds each.

Claims

1. An implantable variable rate pacemaker adaptive to patient exercise, comprising

means for detecting movements of the patient,

means responsive to the detected movements for discriminating between those of the detected movements which are related to physical exercise by the patient and those of the detected movements which are not related to physical exercise by the patient,

means for sampling the detected movements related to physical exercise in successive equal intervals of time to determine whether the physical exercise is more vigorous or less vigorous than was determined for prior time intervals, and

means responsive to the determination for adjusting the rate of said pacemaker accordingly.

2. The invention of claim 1, wherein

said detecting means includes an accelerometer for converting the mechanical movements of the patient to an electrical signal whose frequency and amplitude vary with the rapidity and intensity of said detected movements,

said discriminating means includes means for selectively limiting said electrical signal to appreciable amplitude values in a preselected frequency range, and

said sampling means includes

means for detecting maximum and minimum amplitude values of said electrical signal in each said time interval,

means for calculating the differential between the detected maximum and minimum amplitude values in each time interval over a predetermined number of consecutive ones of the time intervals, and

means for averaging the calculated differentials over said predetermined number of consecutive ones of the time intervals and comparing the average of the calculated differentials so obtained with the average obtained for the immediately preceding consecutive time intervals of the same number to determine from the comparison whether the physical exercise is becoming more or less vigorous with time.

3. The invention of claim 2, wherein said sampling means examines said time intervals at sufficiently low sampling rates to conserve energy in said pacemaker.

4. The invention of claim 3, wherein said time intervals are each 300 milliseconds in length.

5. The invention of claim 2, wherein said accelerometer comprises a semiconductor device.

6. The invention of claim 5, wherein said discriminating means includes an electrical circuit integral with said semiconductor device for processing said electrical signal produced by said accelerometer.

7. A variable rate pacemaker responsive to patient exercise, comprising

motion sensing means for sensing physical activity of the patient and producing an electrical signal having amplitude maximum and minimum values representative of the speed and intensity of said physical activity,

means for selectively limiting said electrical signal to appreciable amplitude values for the detected physical activity which is related to true physical exercise by the patient in contrast to the detected physical activity which is related to internal and external disturbances on the patient not representative of true physical exercise,

means for detecting the amplitude maximum and minimum values of said selectively limited electrical signal in successive equal intervals of time,

means for comparing the detected values for consecutive blocks of time each containing the same number of successive equal intervals of time to determine from the comparison whether the physical exercise represented by the detected values for the most recent block is more vigorous or less vigorous than the physical exercise represented by the detected values for the immediately preceding block, and

means for changing the rate of said pacemaker according to the determination of whether the physical exercise is more vigorous or less vigorous with time.

8. The invention of claim 7, wherein said detecting means operates at a relatively low sampling rate to conserve energy in said pacemaker.

9. The invention of claim 8, wherein each of said intervals of time is 300 milliseconds long.

10. The invention of claim 7, wherein said motion sensing means includes an accelerometer.

11. The invention of claim 10, wherein said selective limiting means includes bandpass filter means having a preselected frequency range for filtering the electrical signal produced said accelerometer.

12. The invention of claim 10, wherein said pacemaker includes a housing, and wherein said accelerometer is situated within and isolated from said housing.

13. The invention of claim 12, wherein said accelerometer comprises a semiconductor device.

14. The invention of claim 13, wherein said selective limiting means includes an electrical circuit integral with said semiconductor device for processing said electrical signal produced by said accelerometer.

15. A process for controlling the heart rate of a patient by artificial stimulation of the heart at a variable rate according to patient exercise, comprising the steps of

detecting movements of the patient,

discriminating between those of the detected movements which are indicative of physical exercise by the patient and those of the detected movements which are not related to physical exercise by the patient,

sampling the detected movements which are indicative of physical exercise in sets of successive equal intervals of time,

comparing the samples from the most recent sampled set of time intervals with the samples from the immediately preceding sampled set of time intervals to determine whether the physical exercise by the patient is more vigorous or less vigorous with time, and

changing the rate of artificial stimulation of the patient'"'"'s heart to reflect changes in the vigorousness of the physical exercise determined from the comparison.

16. The process of claim 15, wherein

the detecting step includes

converting mechanical movements of the patient to an electrical signal whose frequency and amplitude vary with the rapidity and intensity of the detected movements;

the discriminating step includes

filtering the electrical signal to pass the frequency components thereof in a preselected frequency range; and

the sampling step includes

detecting maximum and minimum amplitude values of the electrical signal in each time interval of a set,

storing the differences between the maximum and minimum values in each time interval of a set,

averaging the differences for all of the time intervals over a set, and

comparing the averages of consecutive sets to determine whether the physical exercise by the patient is becoming more or less vigorous with time.