Immunization implant and method
First Claim
1. An implant capsule for immunizing an animal against parasite infection, comprising at least one antigen-producing parasite coated with a positively charged intermediate bonding material and encapsulated within one or more semipermeable polymeric envelope membranes, wherein said parasite is a mammalian parasite within the Phyla Protozoa, Platyhelminthes or Nemathelminthes.
2 Assignments
0 Petitions
Accused Products
Abstract
Antigenic parasites are encapsulated in semipermeable polymeric envelope membranes to prepare implant capsules for immunizing an animal against parasitic infection. An animal may be immunized against parasitic infection by implanting into the animal the implant capsule at a location in the animal sufficient to stimulate a protective immune response in the animal to the parasite antigen.
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Citations
32 Claims
- 1. An implant capsule for immunizing an animal against parasite infection, comprising at least one antigen-producing parasite coated with a positively charged intermediate bonding material and encapsulated within one or more semipermeable polymeric envelope membranes, wherein said parasite is a mammalian parasite within the Phyla Protozoa, Platyhelminthes or Nemathelminthes.
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2. An implant capsule for immunizing an animal against parasite infection, comprising at least one antigen-producing parasite coated with a positively charged intermediate bonding material and encapsulated within one or more semipermeable polymeric envelope membranes, wherein said parasite is an organism selected from the group consisting of parasites from the groups Toxocara, Giardia, Leishmania, Trypanosoma, Entamoeba, Toxoplasma, Plasmodium, Schistosoma, Taenia, Dipylidium, Hymenolepis, Echinococcus, Ascaris, Ancyclostomatidae, Strongylida, Trichuris, Filaroidea and Onchocerca.
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3. An implant capsule for immunizing an animal against parasite infection, comprising at least one antigen-producing parasite coated with a positively charged intermediate bonding material and encapsulated within one or more semipermeable polymeric envelope membranes, wherein said parasite is selected from the group consisting of Toxocara canis, Strongylus vulgaris, Dirofilaria immitis, Fasciola hepatica, Leishmania braziliensis, Leishmania donovani, Leishmania mexicana, Trypanosoma cruzi and Toxoplasma gondii.
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5. An implant capsule for immunizing an animal against parasite infection, comprising at least one antigen-producing parasite coated with a positively charged intermediate bonding material and encapsulated within one or more intermediate bonding material and encapsulated within one or more semipermeable polymeric envelope membranes, wherein said polymeric envelope membrane is a polycationic polyamino acid polymer, a polyanionic polyamino acid polymer, or a combination thereof and said polycationic polyamino acid is polyarginine, polylysine, or polyornithine.
- 7. An implant capsule for immunizing an animal against parasite infection, comprising at least one antigen-producing parasite coated with a positively charged intermediate bonding material and encapsulated within one or more semipermeable polymeric envelope membranes, wherein said polymeric envelope membrane is a polycationic polyamino acid polymer, a polyanionic polyamino acid polymer, or a combination thereof and said intermediate bonding material comprises a polysaccharide-containing material and a biocompatible gellable metal hydroxide.
- 11. An implant capsule for immunizing an animal against parasite infection, comprising at least one antigen-producing parasite coated with a positively charged intermediate bonding material and encapsulated within one or more semipermeable polymeric envelope membranes, wherein said intermediate bonding material contains an immunologic adjuvant.
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13. An implant capsule for immunizing an animal against parasite infection, comprising at least one antigen-producing parasite coated with a positively charged intermediate bonding material and encapsulated within one or more semipermeable polymeric envelope membranes, wherein said polymeric envelope membrane is a biocompatible biodegradable polymer selected from the group consisting of poly(lactide-co-glycolide) polymers, poly(epsiloncaprolactone) polymers and copolymers thereof, poly(hydroxybutyric acid)-poly(hydroxyvalerate) copolymers and poly(Cbz-tyrosine-tyrosinehexyl ester) iminocarbonate.
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14. An implant capsule for immunizing an animal against parasitic infection, wherein said implant capsule is prepared by the steps of:
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(a) suspending a parasite capable of producing antigens in an aqueous growth medium; (b) coating said parasite with a gellable positively charged intermediate bonding material; and (c) encapsulating said coated parasite with a polyanionic semipermeable polymeric envelope, membrane. - View Dependent Claims (15, 16, 17, 18, 19, 30)
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20. A method of immunizing an animal against parasitic infection, comprising the step of implanting into an animal, an implant capsule comprising at least one antigen-producing parasite coated with a positively charged intermediate bonding material and encapsulated within one or more semipermeable polymeric envelope membranes;
- at a location in said animal sufficient to stimulate a protective immune response in said animal to said parasite antigen.
- View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 31, 32)
Specification