Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine
First Claim
1. A sustained release capsule or tablet formulation suitable for once daily administration comprising an adsorbate of a mixture of 1 part by weight of a pharmaceutically acceptable substantially amorphous dihydropyridine and from 0.1 to 10 parts by weight of a polyvinylpyrrolidone having an average molecular weight of at least 55,000 and having a viscosity which serves to sustain the release of active ingredients, the mixture being adsorbed on a cross-linked polyvinylpyrrolidone in a ratio of 1 part by weight of said mixture to 0.5 to 20 parts by weight of cross-linked polyvinylpyrrolidone, blended with a polymeric material which gels in the presence of water, wherein said polymeric material is selected from the group consisting of a pharmaceutically acceptable water-soluble polymer, a pharmaceutically acceptable water-insoluble polymer or mixtures of said polymers, the amount and ratio of said water-soluble polymer to said water-insoluble polymer being effective in combination with the viscosity of the polyvinylpyrrolidone to produce the desired sustained release effect.
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Abstract
A sustained release capsule or tablet formulation suitable for once-daily administration comprises an adsorbate of a mixture of a pharmaceutically useful dihydropyridine and a polyvinylpyrrolidone having an average-molecular weight greater than 55,000 adsorbed on a cross-linked polyvinylpyrrolidone and blended with a polymer or mixture of polymers which gel in the presence of water, the amount of said polymer or polymers being effective to produce the desired sustained release effect.
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Citations
14 Claims
- 1. A sustained release capsule or tablet formulation suitable for once daily administration comprising an adsorbate of a mixture of 1 part by weight of a pharmaceutically acceptable substantially amorphous dihydropyridine and from 0.1 to 10 parts by weight of a polyvinylpyrrolidone having an average molecular weight of at least 55,000 and having a viscosity which serves to sustain the release of active ingredients, the mixture being adsorbed on a cross-linked polyvinylpyrrolidone in a ratio of 1 part by weight of said mixture to 0.5 to 20 parts by weight of cross-linked polyvinylpyrrolidone, blended with a polymeric material which gels in the presence of water, wherein said polymeric material is selected from the group consisting of a pharmaceutically acceptable water-soluble polymer, a pharmaceutically acceptable water-insoluble polymer or mixtures of said polymers, the amount and ratio of said water-soluble polymer to said water-insoluble polymer being effective in combination with the viscosity of the polyvinylpyrrolidone to produce the desired sustained release effect.
Specification