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Process for the preparation of insulin derivatives, the B chain of which is lengthened c-terminally

  • US 5,015,728 A
  • Filed: 03/23/1988
  • Issued: 05/14/1991
  • Est. Priority Date: 09/17/1983
  • Status: Expired due to Term
First Claim
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1. A process for the preparation of an insulin derivative of formula I comprising an aqueous solvent reacting, in ndopeptidase and an insulin of formula II ##STR3## with a peptide of formula III


  • space="preserve" listing-type="equation">H--R.sup. 30--R.sup. 31 TM (III)
to produce the insulin derivative of formula I ##STR4## wherein said insulin derivative I has an isoelectric point of above about 5.8, andR1 denotes H or H-Phe,R30 represents a radical of a neutral or basic naturally occuring L-amino acid,R31 represents a physiologically acceptable organic group of neutral or basic character, consisting of 1 to 3 α

-amino acids in which the terminal carboxyl function is present in a free form, wherein at least one of R30 and R31 is of a basic character,R30a denotes a radical of a genetically codable L-amino acid andR31a represents OH or a protective group of a carboxyl function.

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