Local application of medication with ultrasound
First Claim
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1. A method for applying a therapeutic substance to body tissue of a person or animal, comprising the steps of:
- supplying said therapeutic substance in a receptacle having a surface portion formed of porous material having a selected porosity;
implanting said receptacle in said person or animal with said surface portion adjoining said body tissue; and
irradiating said implanted receptacle with ultrasonic radiation thereby to cause said therapeutic substance to diffuse through said porous surface portion at a greater rate than in the absence of said radiation and thereby applying said therapeutic substance to said tissue so that the rate of application of said therapeutic substance to said tissue is controlled by the exposure of said receptacle to said ultrasonic radiation.
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Abstract
A method and an apparatus for applying a therapeutic substance to body tissue are provided in which ultrasonic radiation is used. The method allows the application of medication to be tailored to the needs of an individual patient. In particular, the timing, duration, intensity, and concentration of the application of medication can be adjusted according to individual requirements. Side effects of tissue adjacent to tissue in need o
The invention described herein was made in the course of work under a grant from the National Institute of Health.
180 Citations
14 Claims
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1. A method for applying a therapeutic substance to body tissue of a person or animal, comprising the steps of:
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supplying said therapeutic substance in a receptacle having a surface portion formed of porous material having a selected porosity; implanting said receptacle in said person or animal with said surface portion adjoining said body tissue; and irradiating said implanted receptacle with ultrasonic radiation thereby to cause said therapeutic substance to diffuse through said porous surface portion at a greater rate than in the absence of said radiation and thereby applying said therapeutic substance to said tissue so that the rate of application of said therapeutic substance to said tissue is controlled by the exposure of said receptacle to said ultrasonic radiation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of applying a therapeutic substance to body tissue of a person or animal, comprising the steps of:
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encapsulating said therapeutic substance in a receptacle having a surface portion formed of porous material having a selected porosity; positioning said receptacle adjacent said body tissue with said porous surface portion adjoining said body tissue; and passing ultrasonic radiation through said receptacle, across said surface portion and into said tissue thereby to diffuse said therapeutic substance into said tissue so that the rate of application of said therapeutic substance to said tissue is controlled by the exposure of said receptacle to said ultrasonic radiation substance. - View Dependent Claims (14)
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Specification