Dosage unit for dosing a number of measured quantities of a liquid, such as an insulin preparation, from a container, preferably a cartridge

• US 5,017,190 A
• Filed: 10/05/1989
• Issued: 05/21/1991
• Est. Priority Date: 04/07/1987
• Status: Expired due to Fees

• Current Assignee: DCP AF 1988 A/S Denmark
• Original Assignee: DCP AF 1988 A/S Denmark
• Inventors: Simon, Bernd, Holm, Niels E., Bonnichsen, Fritz F.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): RAFA, MICHAEL
• Application Number:
  US07/411,506
• Time in Patent Office: 593 Days
• Field of Search: 604/187, 604/207-411, 604/218-220, 604/110
• US Class Current: 604/207
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: G01F 11/023 with provision for varying the stroke of the piston

Abstract

A dosage unit for dosing a number of measured quantities of a liquid, such as insulin, from a cartridge (2), said dosage unit comprising a cylindrical casing (1) for the cartridge (2), the distal end of the casing (1) being provided with means for fastening an injection needle (5) with two points protruding at opposite sides, one point (7) thereof being provided to be plunged into the cartridge (2). The other end of the casing comprises a piston rod (13) for exerting a force on a piston (8) inside the cartridge (2) and an adjustment means (20) provided with an inner thread (21), said adjustment means being in rotatable engagement with an outer thread (19) on the outside of the casing (1). The adjustment means (20) is adapted to limit the length of the stroke of the piston rod (13) after adjustment in accordance with a measuring scale (37, 38) stating the desired dosage quantity. This dosage unit enables an easy and precise adjustment of the desired quantity and ensures that the dosage unit cannot be used again inadvertently, when the cartridge is empty.

Claims

1. A dosage unit for dosing a number of measured quantities of a liquid, such as an insulin preparation, from a container, preferably a separate cartridge, said dosage unit comprising a cylindrical casing for the container, the distal end of the casing being provided with means for fastening a double-pointed injection needle, one point thereof being provided to pierce a membrane closing one end of the container, and said dosage unit comprising a piston rod for exerting a force on a piston closing the other end of the container, and an adjustment means provided with an internal thread, said adjustment means being in rotatable engagement with an external thread on the casing and adapted to adjust the length of the stroke of the piston rod according to the dosage needed in each case, the dosage being adjusted to be readable on a scale located on the dosage unit, characterised in that the dosage unit is provided with a first ratchet means (17) between the casing (1) and the piston rod (13), said ratchet means allowing the displacement of the piston rod (13) in a direction towards the distal end of the casing and preventing the displacement in the opposite direction, and with a second ratchet means (32) between the adjustment means (20) and the casing (1) or a second part of the dosage unit, which is unturnable in relation to the casing, and in relation to which the adjustment means is rotatable, said second ratchet means allowing the rotation of the adjustment means (20) in a direction forward towards the distal end of the casing (1) and preventing the rotation in the opposite direction.

2. A dosage unit as claimed in claim 1, characterised in that the first ratchet means (17) is formed by circumferential, radial shoulders (14, 15) on the piston rod (13), each shoulder being bounded by conical surfaces (16) tapering in a direction towards the front end of the piston rod (13), seen in the direction of movement during use, and where said shoulders (14, 15) and surfaces (16) cooperate with a circumferential collar acting as a pawl (11), said collar being an integral part of the casing (1) at the place, where the piston rod (13) passes into the casing, and protruding forward towards the distal end of the casing.

3. A dosage unit as claimed in claim 2, characterised in that the piston rod (13) is provided with longitudinal grooves (28, 29, 30 and 31) for radially inwardly protruding projections (33, 34, 35 and 36) provided on the collar acting as a pawl (11) on the casing (1).

4. A dosage unit as claimed in claim 3, characterised in that the second ratchet means (32) comprises a projection (25) acting as a pawl, said projection being an integral part of the proximal end of the adjustment sleeve (20) and capable of engaging the longitudinal grooves (28, 29, 30 and 31) of the piston rod (13).

5. A dosage unit as claimed in claim 4, characterised in that the longitudinal grooves (28, 29, 30 and 31) of the piston rod (13) are spaced at equal distances from one another around an outside surface of the piston rod (13).

6. A dosage unit as claimed in claim 2 or 3, characterised in that the collar acting as a pawl (11) is connected with the casing (1) by means of a flange protruding radially inwards from the casing, said flange being of such a radial dimension that the proximal edge of the container in form of a cartridge (2) is received herein, when the container is correctly positioned in the dosage unit.

7. A dosage unit as claimed in claim 1, 2, 3, 4, or 5 characterised in that the adjustment means (20) is in form of an oblong sleeve being substantially of the same extension as the piston rod (13) and the piston (8), and the external thread (19) on the casing (1) cooperating with the adjustment sleeve is placed adjacent to the proximal end of the casing (1) and within an axial area ending at the front end of the piston of the container, when the dosage unit is ready for its first use.

8. A dosage unit as claimed in claim 6, characterised in that the adjustment means (20) is in the form of an oblong sleeve being substantially of the same extension as the piston rod (13) and the piston (8), and the external thread (19) on the casing (1) cooperating with the adjustment sleeve is placed adjacent to the proximal end of the casing (1) and within an axial area ending at the front end of the piston of the container, when the dosage unit is ready for its first use.

9. A dosage unit as claimed in claim 6, characterised in that the piston rod has a longitudinal measuring scale (38) on its outside for reading the number of dosage units delivered with each full turn of the adjustment means (20).

10. A dosage unit as claimed in claim 7, characterised in that the piston rod has a longitudinal measuring scale (38) on its outside for reading the number of dosage units delivered with each full turn of the adjustment means (20).

11. A dosage unit as claimed in claim 7, characterised in that the proximal end of the piston rod is provided with a radially protruding head (22) outside the adjustment means (20), said head being adapted to go into abutment with the adjacent end of the adjustment means, when the dosage quantity in question has been delivered.

12. A dosage unit as claimed in claim 11, characterised in that a circumferential measuring scale (37) is provided at the proximal end of the adjustment means (20) and having an angular distance between the markings corresponding to the angular distance between the grooves in the piston rod, and a protective cap (9) for the needle (5) of the dosage unit is adapted to be fastened in a desired rotating position at the head (22) of the piston rod (13) during the use of the dosage unit, said cap carrying a marking to be set in front of the zero point of the measuring scale (37) of the adjustment means (20).

13. A dosage unit as claimed in claim 5, 11 or 12, characterised in that the piston rod has a longitudinal measuring scale (38) on its outside for reading the number of dosage units delivered with each full turn of the adjustment means (20).

14. A dosage unit for dosing a number of measured quantities of a liquid, such as an insulin preparation, from a container, preferably a separate cartridge, said dosage unit comprising a cylindrical casing for the container, the distal end of the casing being provided with means for fastening a double-pointed injection needle, one point thereof being provided to pierce a membrane closing one end of the container, and said dosage unit comprising a piston rod for exerting a force on a piston closing the other end of the container, and an adjustment means provided with an internal thread, said adjustment means being in rotatable engagement with an external thread on the casing and adapted to adjust the length of the stroke of the piston rod according to the dosage needed in each case, the dosage being adjusted to be readable on a scale located on the dosage unit, characterised in that the dosage unit is provided with a first ratchet means (17) between the casing (1) and the piston rod (13), said ratchet means allowing the displacement of the piston rod (13) in a direction towards the distal end of the casing and preventing the displacement in the opposite direction, and with a second ratchet means (32) between the adjustment means (20) and the casing (1) or a second part of the dosage unit, which is unturnable in relation to the casing, and in relation to which the adjustment means is rotatable, said second ratchet means allowing the rotation of the adjustment means (20) in a direction forward towards the distal end of the casing (1) and preventing the rotation in the opposite direction, the ratchet means (17, 32) being adapted in such a way that the effect of the movement-impeding parts can temporarily be overcome by exerting a stronger force.