Apparatus for measuring the components of a sample

• US 5,017,339 A
• Filed: 03/28/1989
• Issued: 05/21/1991
• Est. Priority Date: 03/28/1988
• Status: Expired due to Fees

• Current Assignee: AVL AG Grabenstrasse
• Original Assignee: AVL AG
• Inventors: Fischer, Fritz, Kleinhappl, Erich, Marsoner, Hermann
• Primary Examiner(s): Lacey, David L.
• Assistant Examiner(s): REDDING, DAVID A
• Application Number:
  US07/329,837
• Time in Patent Office: 784 Days
• Field of Search: 422/81, 422/82.03, 422/82.04, 436/52, 436/60, 436/150, 436/151, 204/403, 204/409, 204/411
• US Class Current: 204/403.02
• CPC Class Codes: G01N 35/00 Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Abstract

An apparatus for measuring the properties of a sample includes a sensor block with at least one sensor module whose housing contains a measuring chamber in contact with a sensor, the housing of the sensor module M including a mixing chamber for indirect measurement of a sample property, which chamber is placed upstream of the measuring chamber, and is connected with a sample channel and a reagent channel. Due to the modular design of the sensor block, the sample and reagent paths in the sensor block or sensor module may be kept short; along with the compact arrangement of mixing chamber and measuring chamber this permits the required sample and reagent volumes to be kept to a minimum.

Claims

1. An apparatus for measuring chemical and physico-chemical properties of a sample, comprising

a sensor block with at least one sensor module for indirect measurement of at least one sample property, said sensor module comprising a housing which contains a sample channel and a measuring chamber which is contacted by a sensor,

a removable mixer part containing a mixing chamber with a magnetic stirrer and having at least one connection for said sample and a reagent medium and a channel leading into said measuring chamber, said mixer part being positionable in said housing of said sensor module, and

two magnetic conductors positioned in said mixer part which are connectable with a magnetizing coil and are directed towards said magnetic stirrer in said mixing chamber, wherein for indirect measurement of at least one of said sample properties said sample and said reagent medium are mixed in said mixing chamber.

2. An apparatus according to claim 1, further including a tightening mechanism positioned so as to press said sensor module against a stationary end piece of said sensor block, said sample channel of said sensor module being sealingly connectable to a channel section in said end piece, and wherein said magnetizing coil is located in a pressure element of said tightening mechanism, spring elements positioned so as to press said pressure element against said movable mixer part of said sensor module, and wherein magnetic conductors extending from said magnetizing coil are located in said pressure element and can contact said magnetic conductors in said mixer part.

3. An apparatus according to claim 1, wherein said housing of said sensor module is provided with a spring-loaded arresting knob positioned and arranged so as to sealingly press said removable mixer part towards said measuring chamber.

4. An apparatus according to claim 1, wherein said mixer part is provided with a locking part sealing said mixing chamber, a central bore of said locking part is sealed against said channel towards said measuring chamber, and wherein said locking part has a hollow cylindrical stub projecting into said mixing chamber.

5. An apparatus according to claim 1, further comprising a reagent channel which opens into said sample channel immediately in front of said mixing chamber.

6. An apparatus according to claim 1, comprising a feeder device for sample and standard media connected with said sample channel of said sensor module, vessels for standard media and a feed pump for transport of said sample and standard media, wherein a tube running from a reagent vessel to said reagent connection of said sensor module, and a tube running from said feeder device to said sample channel of said sensor module are both acted upon by a joint peristaltic pump.

7. An apparatus according to claim 1, wherein said sensor module contains a CO₂ sensor for measuring the total carbon dioxide in a sample of blood serum.

8. An apparatus according to claim 2, wherein at least one sensor module for direct measurement of at least one of said sample properties is positioned between said stationary end piece of said sensor block and said sensor module for indirect measurement of at least one of said sample properties and has two connections, one of said connections of said sensor module for direct measurement being sealingly connected to said sample channel of an adjacent sensor module, the other of said connections is sealingly connected to said channel section in said end piece.

9. An apparatus according to claim 2, comprising at least one electrochemical sensor in one of said sensor modules, wherein said channel section in said end piece is made of electrically conductive material and is connected to an electric lead.

10. An apparatus according to claim 8, comprising a feeder device for sample and standard media connected with said channel section of said end piece, vessels for standard media and a feed pump for transport of said sample and standard media, wherein a tube running from a reagent vessel to said reagent connection of said sensor module for indirect measurement, and a tube running from said feeder device to said channel section of said end piece are both acted upon by a joint peristaltic pump.

11. An apparatus according to claim 10, wherein said tube extending from said reagent vessel to said reagent connection and said tube extending from said feeder device to said sample channel have differ cross-sections.

12. An apparatus according to claim 10, including at least one electrochemical sensor positioned in one of said sensor modules and wherein a reference electrode is located in said reagent tube.

13. An apparatus according to claim 12, wherein said reference electrode is located, outside of said sensor block.

14. An apparatus according to claim 6, wherein said tube extending from said reagent vessel to said reagent connection and said tube extending from said feeder device to said sample channel have different cross-sections.

15. An apparatus according to claim 6, including at least one electrochemical sensor positioned in one of said said sensor modules and wherein a reference electrode is located in said reagent tube.

16. An apparatus according to claim 15, wherein said reference electrode is positioned outside of said sensor block.