Method of producing antibody-fortified dry whey
First Claim
1. A dry whey protein powder fortified with polyclonal antibodies against preselected infectious intestinal disease antigens made according to a method comprising the steps of:
- a. immunizing a pregnant ungulate by administration to the ungulate of the preselected infectious intestinal disease antigens in a non-pathogenic condition;
b. collecting and maintaining the milk from the ungulate after parturition, the milk containing a higher than normal concentration of antibodies against the preselected infectious intestinal disease antigens because of the immunization step;
c. producing unfractionated whey fortified with naturally occurring polyclonal antibodies against the preselected infectious intestinal disease antigens from the milk by removing milk casein; and
d. concentrating and drying the unfractionated whey to produce a whey protein powder fortified with naturally occurring polyclonal antibodies against the preselected infectious intestinal disease antigens.
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Abstract
A method of producing a dry whey protein powder fortified with naturally occurring polyclonal antibody IgG to preselected infectious intestinal disease antigens, primarily diarrhea-causing enterotoxigenic Escherichia coli bacteria bearing colonization factor antigens (CFA) I or II and heat labile toxins. The product is made by first immunizing a pregnant ungulate, such as a cow, by administration of antigens of the preselected disease. After parturition the milk from the ungulate is collected and maintained in its natural state. The milk is subjected to a standard cheese-making process which produces coagulated casein and whey. The antibody IgG is carried into the whey, which is concentrated and dried. The resulting dried protein powder contains the antibody. The product may be administered orally to living beings, both humans and other animals, to prevent contraction of the preselected disease and to treat bodies exposed to the disease.
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Citations
20 Claims
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1. A dry whey protein powder fortified with polyclonal antibodies against preselected infectious intestinal disease antigens made according to a method comprising the steps of:
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a. immunizing a pregnant ungulate by administration to the ungulate of the preselected infectious intestinal disease antigens in a non-pathogenic condition; b. collecting and maintaining the milk from the ungulate after parturition, the milk containing a higher than normal concentration of antibodies against the preselected infectious intestinal disease antigens because of the immunization step; c. producing unfractionated whey fortified with naturally occurring polyclonal antibodies against the preselected infectious intestinal disease antigens from the milk by removing milk casein; and d. concentrating and drying the unfractionated whey to produce a whey protein powder fortified with naturally occurring polyclonal antibodies against the preselected infectious intestinal disease antigens. - View Dependent Claims (2, 15, 16)
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3. A method of preventing an intestinal disease in a human or animal comprising prophylactically administering to the human or animal an effective oral dose of a dry whey powder fortified with polyclonal antibodies against antigens associated with the intestinal disease made according to a method comprising the steps of:
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a. immunizing a pregnant ungulate by administration to the ungulate the antigens associated with the intestinal disease in a non-pathogenic condition; b. collecting and maintaining the milk from the ungulate after parturition, the milk containing a higher than normal concentration of polyclonal antibodies against antigens associated with the intestinal disease because of the immunization step; c. producing unfractionated whey fortified with naturally occurring polyclonal antibodies against the intestinal disease antigens from the milk by removing milk casein; and d. concentrating and drying the unfractionated whey to produce a whey protein powder fortified with naturally occurring polyclonal antibodies against the intestinal disease antigens. - View Dependent Claims (4, 5, 6, 7, 8, 17, 18)
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9. A method of treating an intestinal disease in a human or animal comprising administering to the human or animal with the intestinal disease an effective oral dose of a dry whey powder fortified with polyclonal antibodies against antigens associated with the intestinal disease made according to a method comprising the steps of:
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a. immunizing a pregnant ungulate by administration to the ungulate the antigens associated with the intestinal disease in a non-pathogenic condition; b. collecting and maintaining the milk from the ungulate after parturition, the milk containing a higher than normal concentration of polyclonal antibodies against antigens associated with the intestinal disease because of the immunization step; c. producing unfractionated whey fortified with naturally occurring polyclonal antibodies against the intestinal disease antigens from the milk by removing milk casein; and d. concentrating and drying the unfractionated whey to produce a whey protein powder fortified with naturally occurring polyclonal antibodies against the intestinal disease antigens. - View Dependent Claims (10, 11, 12, 13, 14, 19, 20)
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Specification