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Intraorgan injection of biologically active compounds contained in slow-release microcapsules or microspheres

  • US 5,017,378 A
  • Filed: 05/01/1989
  • Issued: 05/21/1991
  • Est. Priority Date: 05/01/1989
  • Status: Expired due to Fees
First Claim
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1. A method for increasing fertility in males with impairment of testosterone synthesis, comprising the step of:

  • injecting slow-release microcapsules or microspheres containing testosterone directly into testes, wherein the microcapsules or microspheres containing testosterone act as temporary Leydig cells and release testosterone directly into a testicular parenchyma and maintain intratesticular concentration of testosterone sufficient for spermatogenesis, wherein the slow-release microcapsules or microspheres are slow-release biodegradable polyactone microcapsules or microspheres.

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