System and method using chemicals and ultrasound or ultrasound alone to replace more conventional surgery

• US 5,018,508 A
• Filed: 03/14/1990
• Issued: 05/28/1991
• Est. Priority Date: 06/03/1988
• Status: Expired due to Fees

• Current Assignee: Indianapolis Center for Advanced Research, Inc.
• Original Assignee: Indianapolis Center for Advanced Research, Inc.
• Inventors: Griffith, Steven L., Fry, Francis J.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Zele, John D.
• Application Number:
  US07/493,442
• Time in Patent Office: 440 Days
• Field of Search: 128/24 A, 128/660.03, 604/22, 604/28, 604/48
• US Class Current: 601/2
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A method for rendering a gallbladder dysfunctional without surgical removal comprises the steps of infusing the gallbladder with methyl-tert-butyl ether (MTBE), then, while the gallbladder is so infused, irradiating the gallbladder with an ultrasound beam in such an ultrasound delivery format as not to elevate the average temperature of the gallbladder more than five degrees Centigrade over the period of treatment, and then removing the MTBE from the gallbladder.

Claims

1. A method for rendering a gallbladder dysfunctional without surgical removal comprising the steps of infusing the gallbladder with methyl-tert-butyl ether (MTBE), then, while the gallbladder is so infused, irradiating the gallbladder with an ultrasound beam in such an ultrasound delivery format as not to elevate the average temperature of the gallbladder more than five degrees Centigrade over the period of treatment, and then removing the MTBE from the gallbladder, and then repeating these steps a sufficient number of times to render the gallbladder dysfunctional.

2. The method of claim 1 wherein the steps of infusing the gallbladder with MTBE and then removing the MTBE from the gallbladder comprise the steps of placing a catheter into the gallbladder, periodically administering MTBE bolus into the gallbladder, and periodically removing the MTBE from the gallbladder.

3. The method of claim 1 and further comprising the step of flushing the gallbladder with a sterile fluid after the step of removing the MTBE from the gallbladder.

4. The method of 1 wherein the ultrasound delivery format includes a frequency in the range of 200-250 KHz, a spatial peak-temporal peak (SPTP) intensity of 12-24 W/cm² over the cross sectional area of the gallbladder, a duty cycle in the range of 10%-20%, and an ultrasound exposure time of 30-90 minutes.