Agglutination reaction slide
First Claim
1. A test element for an agglutination test of a sample-reagent mixture, comprising at least one pair of plate members defining therebetween a reaction capillary having a predetermined thickness for the sample-reagent mixture to flow through the capillary, the reaction capillary having an input end and an output end, the input end of the reaction capillary being fluidically connected to a zone for receiving and mixing the sample with the reagent, wherein:
- the reaction capillary has a substantially rectangular cross-sectional configuration in a direction perpendicular to the flow of the sample-reagent mixture,the reaction capillary further has an upstream region with a thickness at the input end of between about 50 and about 100 μ
m and a downstream region with a thickness at the output end of between about 200 and about 300 μ
m, the thickness of the reaction capillary increasing from the upstream region toward the downstream region, andthe increase in the reaction capillary thickness is substantially continuous and linear over the length of each region.
2 Assignments
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Accused Products
Abstract
A test element for agglutination tests, comprising a receiving and mixing region for a sample and reagents and a reaction capillary having an upstream region which produces a capillary effect causing the sample-reagents mixture to flow at a speed which is greater than along a downstream region of the reaction capillary. An intermediate region can be provided between the upstream capillary region and the downstream region. The downstream end of capillary is connected to a collecting region. The test element is characterized by continuous supply and movement of the sample-reagents mixture through the reaction capillary. More particularly the time needed for a sample-reagents mixture to flow from the upstream end to the downstream end of the reaction capillary fluctuates only slightly between tests. The test element is particularly suitable for detecting drugs of abuse such as cocaine metabolites in human body fluids.
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Citations
17 Claims
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1. A test element for an agglutination test of a sample-reagent mixture, comprising at least one pair of plate members defining therebetween a reaction capillary having a predetermined thickness for the sample-reagent mixture to flow through the capillary, the reaction capillary having an input end and an output end, the input end of the reaction capillary being fluidically connected to a zone for receiving and mixing the sample with the reagent, wherein:
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the reaction capillary has a substantially rectangular cross-sectional configuration in a direction perpendicular to the flow of the sample-reagent mixture, the reaction capillary further has an upstream region with a thickness at the input end of between about 50 and about 100 μ
m and a downstream region with a thickness at the output end of between about 200 and about 300 μ
m, the thickness of the reaction capillary increasing from the upstream region toward the downstream region, andthe increase in the reaction capillary thickness is substantially continuous and linear over the length of each region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A test element for use in detecting the agglutination of a sample-reagent mixture, comprising a top plate member and a bottom plate member secured together, at least one of said plate members defining a channel having a predetermined thickness and configured to form a reaction capillary between the plate members for passing the sample-reagent mixture therethrough, the reaction capillary having an input end and an output end, the reaction capillary having an upstream region with a thickness at the input end of between about 50 and about 100 μ
- m and with means defining an aperture at the input end for receiving the sample-reagent mixture, and a downstream region fluidically communicating with the upstream region and with a thickness at the output end of between about 200 and about 300 μ
m, wherein the reaction capillary has a substantially rectangular cross-sectional configuration in a direction perpendicular to the flow of the sample-reagent mixture, the thickness of the reaction capillary increases in a direction from the upstream region toward the downstream region, and the increase of the reaction capillary thickness is substantially continuous and linear over the length of each region. - View Dependent Claims (12, 13, 14, 15, 16, 17)
- m and with means defining an aperture at the input end for receiving the sample-reagent mixture, and a downstream region fluidically communicating with the upstream region and with a thickness at the output end of between about 200 and about 300 μ
Specification