Aqueous emulsion for pharmaceutical dosage form

• US 5,019,397 A
• Filed: 04/21/1988
• Issued: 05/28/1991
• Est. Priority Date: 04/21/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Theeuwes, Felix, Wong, Patrick S. L.
• Primary Examiner(s): Cashion, Jr., Merrell C.
• Assistant Examiner(s): Horne, Tim R.
• Application Number:
  US07/184,478
• Time in Patent Office: 1,132 Days
• Field of Search: 424/473, 424/464, 424/484, 424/485, 424/486, 424/488
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/2846 Poly(meth)acrylates
• CPC Class Codes: A61K 9/2866 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

A dosage form is disclosed comprising a cured emulsion that coat that surrounds a drug. The emulsion comprises a lower alkyl acrylate-lower alkyl methacrylate copolymer and ethyl cellulose. The emulsion optionally comprises a hydrophilic polymer.

Claims

1. An osmotic device comprising:

(a) a wall comprising an aqueous emulsion of a lower alkylacrylate-lower methacrylate wherein the lower alkyl comprises 1 to 7 carbon atoms and an aqueous emulsion of ethyl cellulose, said wall formed by calescence at a temperature up to 65°

C. for up to 72 hours, which wall surrounds;

(b) a compartment;

(c) a therapeutically effective amount of drug in the compartment; and

,

(d) at least one passageway in the wall connecting the exterior with the interior of the device for delivering drug over time.

2. The osmotic device according to claim 1, wherein the emulsion comprises a hydrophilic polymer.

3. THe osmotic device according to claim 1, wherein the drug is nifedipine.

4. The osmotic device according to claim 1, wherein the drug is salbutamol.