Catheter for even distribution of therapeutic fluids

• US 5,021,044 A
• Filed: 01/30/1989
• Issued: 06/04/1991
• Est. Priority Date: 01/30/1989
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Sharkawy, Ahmed
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Dally, Kathleen A.
• Application Number:
  US07/304,062
• Time in Patent Office: 855 Days
• Field of Search: 604/264, 604/280, 604/282, 604/271-275, 604/53, 604/52, 604/49, 604/164, 604/96, 604/102, 604/101, 604/93, 604/173, 604/258, 604/266, 604/268, 138/111, 138/118, 138/124, 138/115, 606/194
• US Class Current: 604/510
• CPC Class Codes: A61M 2025/0039 characterized by lumina being arranged coaxially
• CPC Class Codes: A61M 2025/004 characterized by lumina being arranged circumferentially
• CPC Class Codes: A61M 25/0009 Making of catheters or other medical or surgical tubes

Abstract

A multilumen vascular catheter for the delivery of therapeutic fluids, e.g., containing thrombolytic agents, to a patient'"'"'s blood vessel. The catheter has a plurality of flow passageways in the wall of the outer tubular member in which the discharge openings thereof increase in diametrical dimensions so that a desired, e.g., uniform, flow of treatment fluid is delivered exteriorly of the catheter body. The flow passageways preferably are formed by means of lasers. A first rectangularly shaped passageway is formed in the catheter wall and then a second rectangularly shaped hole is made in the wall, overlapping the first hole to form the final rectangular shape. The catheter is particularly adapted to deliver small quantities of thrombolytic agents, such as urokinase, streptokinase, and tissue plasminogen activator.

Claims

1. A multilumen catheter having an operative distal portion for the uniform delivery of therapeutic fluid to a location within a patient'"'"'s vascular system, comprising:

a) an elongated tubular body having proximal and distal ends, a first longitudinally extendinginner lumen with an axial opening in the distal end of the tubular body which is adapted to receive a guidewire and a sidewall which defines at least in part an additional longitudinally extending inner lumen adapted to receive therapeutic fluid;

b) a plurality of longitudinally spaced fluid passageways which extend radially through the sidewall of the elongated tubular body in the operative distal portion of the catheter from the additional inner lumen to the exterior of the tubular body and which are adapted to direct therapeutic fluid from the additional inner lumen to the exterior of the tubular body, the transverse cross-sectional area of the passageways and the spacing therebetween being controlled to provide a flow discharge area per unit length of the operative distal portion of the catheter which increases in the distal direction to provide a uniform flow of therapeutic fluid to the exterior of the tubular member; and

c) means at the proximal end of the tubular member to direct treatment fluid to the additional lumen adapted to receive said fluid.

2. The catheter of claim 1 wherein the elongated tubular body comprises an inner tubular member having he first lumen disposed longitudinally therein and an outer tubular member disposed concentrically about the inner tubular member and defining an annular additional lumen between the inner and outer tubular members.

3. The catheter of claim 2 wherein the annular additional lumen adapted to receive therapeutic fluid is divided into separate parallel lumens by wells which extend between the inner and outer tubular members.

4. The catheter of claim 1 wherein the flow passageways through the wall of the tubular body are equally spaced in the longitudinal direction.

5. The catheter of claim 1 wherein the flow passageways have transverse cross-sectional areas less than 0.02 mm².

6. The catheter of claim 1 wherein the flow passageways have transverse cross-sectional areas of about 0.001 to about 0.01 mm².

7. The catheter of claim 1 wherein the transverse cross-sectional shape of the flow passageways is rectangular.

8. The catheter of claim 1 wherein the flow passageways through the wall of the tubular body are evenly spaced longitudinally therein.

9. A method for treating a thrombus in a region of a patients s blood vessel comprising:

a) advancing a guidewire through the region of the patient'"'"'s blood vessel having a thrombus;

b) advancing a multilumen catheter over the guidewire until an operative distal portion of the catheter extends into the region having the thrombus, the catheter comprising;

an elongated tubular body having proximal and distal ends, a first lumen with an axial opening in the distal end of the tubular body which receives the guidewire and a wall which defines at least in part an additional inner lumen which receives thrombolytic fluid at the proximal end thereof;

a plurality of radially extending, longitudinally spaced fluid passageways in the operative distal portion of the catheter which extend through the sidewall of the elongated tubular body from the inner lumen, said passageways having

a transverse cross-sectional area increasing in the distal direction so that there is uniform flow of thrombolytic fluid from the additional inner lumen to the exterior of the tubular body along the operative distal portion of the catheter; and

b) directing thrombolytic fluid through the additional inner lumen to discharge such fluid through the radially extending passageways in a uniform manner into thrombus surrounding the operative portion of the catheter along the length thereof.

10. The method of claim 9 wherein the multilumen catheter is withdrawn over the guidewire and a balloon dilatation catheter is advanced over the guidewire so the balloon thereon crosses the lesion in the patient'"'"'s blood vessel which underlies the thrombus inflating the balloon with inflation fluid at elevated pressure to dilate the lesion and then deflating the balloon so the catheter can be withdrawn from the patient'"'"'s blood vessel.