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Biological sensors

  • US 5,023,053 A
  • Filed: 05/22/1989
  • Issued: 06/11/1991
  • Est. Priority Date: 05/20/1988
  • Status: Expired due to Fees
First Claim
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1. A sensor for use in biological, biochemical or chemical testing, said sensor comprising a source of electromagnetic radiation for producing a beam of electromagnetic radiation, membrane in the form of a laminate comprising a first film of transparent material, a second film of metal applied to at least part of one surface of said first film and a third film of sensitive material applied to the second film, said membrane further including a sample feeding means whereby the sample to be analyzed is transferred in a controlled manner to said sensitive layer, said sample feeding means comprising a further layer in the laminate comprising said membrane, which further layer is applied to said third film of sensitive material, said further layer being made of a porous material through which a sample may be passed from the side opposite the sensitive layer, in order to react with said sensitive layer, means for directing said beam of electromagnetic radiation into said first film of transparent material in such a way as to be internally reflected off said part of said one surface, and detector means positioned to receive the internally reflected beam, wherein the angle of incidence of said beam at said one surface is such as to cause surface plasmon resonance to occur, the characteristics of which resonance, as detected by the monitoring means, is dependent upon the reaction between the sample and the sensitive layer.

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