Hematology - diagnosis apparatus employing expert system technology

• US 5,023,785 A
• Filed: 11/16/1987
• Issued: 06/11/1991
• Est. Priority Date: 11/16/1987
• Status: Expired due to Term

• Current Assignee: Becton and Dickinson Company Franklin Lakes New Jersey 07417, Stephen C. Wardlaw
• Original Assignee: Becton, Dickinson & Co
• Inventors: Adrion, Robert F., Curry, Joan W., Levine, Robert A.
• Primary Examiner(s): Smith, Jerry
• Assistant Examiner(s): BUI, KIM T
• Application Number:
  US07/103,935
• Time in Patent Office: 1,303 Days
• Field of Search: 364/413.01, 364/413.02, 364/413.03, 364/413.07, 364/413.08, 364/513, 364/200, 364/900, 128/630
• US Class Current: 600/300
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 70/60 relating to pathologies
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics
• CPC Class Codes: Y10S 706/924 Medical

Abstract

Described is a hematology-diagnosis apparatus employing expert system technology. The apparatus comprises a computer/data processor which is provided with a memory facility, a central processor and a printer. Stored in the memory facility is a knowledge base applicable to hematologic diagnostics, and instructions by which the apparatus is to process input data, in the form of a plurality of--four in a specific exemplary embodiment--hematologic parametric numerics obtained from a patient'"'"'s bood assay. The numerics are entered via entry means. The apparatus accordingly executes the instructions, and on the basis of the parametric numerics, prints out diagnostic and hematologic messages applicable to the patient.

Claims

1. An apparatus for the non-interactive, automatic interpretation of hematology results comprising:

data processing means which includes;

means for evaluating blood-derived parametric values, and

means for ascertaining a clinically important interval (CII) combination applicable to blood-derived parametric values from a listing a plural CII'"'"'s and producing output messages therefrom;

memory means for storing data and data-processing instructions to be executed by the data processing means;

means for entering data which represent the values of hematology parameters derived from a patient'"'"'s blood; and

means for outputting the messages of hematologic/diagnostic significance applicable to the patient;

wherein the memory means stores a data base and execution-instructions of an automatically interpreting hematology-diagnostic system which is suitable for operation upon the hematology parameters and their blood-derived values;

the data base including;

a relatively large number of messages of hematology diagnostic significance, each message being associated with a range of values for each of the hematology parameters, each range of values constituting one CII, and

a listing of the CII'"'"'s within which the blood-derived parametric values may lie, the listing including a series of consecutive CII numbers and a range of values and a descriptive phrase associated with each CII;

the stored execution-instructions causing the data processing means to evaluate the blood-derived parametric values and to retrieve from the memory means the one or more messages whose CII combinations apply to the blood-derived parametric values, wherein the one or more messages are provided in a form to permit the interpretation of the hematologic condition of the patient.

2. The apparatus of claim 1 wherein said stored execution-instructions further include directions to

determine applicable CIIs and associated descriptive phrases, corresponding to each one of the patient'"'"'s input parametric values and prepare for output the applicable descriptive phrases.

3. The apparatus of claim 2 wherein the stored execution-instructions include further directions to the processing means to:

prepare the output for printout with, and aligned to, each applicable descriptive phrase, its associated parameter and the patient-derived value of such associated parameter; and

cause a printout, with the prepared descriptive phrase, the thereto aligned prepared items.

4. The apparatus of claim 1, wherein the parameters are hematocrit (H), platelet count (P), granulocytes (G);

and lymphocyte/monocyte count (L).

5. The apparatus of claim 4 wherein hematocrit (H) is expressed in percent;

and platelet count (P), granulocytes (G), lymphocyte/monocyte count (L), each is expressed in ×

10⁹ /L.

6. The apparatus of claim 1 wherein the stored data base further includes:

an individual reminder message number for, and unique to, each reminder message, the message numbers being in a sequence which runs through the hematologic reminder messages and diagnostic reminder messages.

7. The apparatus of claim 6 wherein the stored data base further includes, for each parameter, and then in turn for each CII number applicable to that parameter, an array of consecutive one-bit positions, the number of such positions in each array being in correspondence to the reminder message numbers, the arrangement being such that for each reminder message number there appears in the thereto corresponding one bit-positions--all parameters and all their respective CII number-arrays considered--a binary one in such corresponding bit-positions, for which the parameter and that parameter'"'"'s CII number are applicable to the corresponding reminder message number and its reminder message, while elsewhere binary zeroes appear.

8. The apparatus of claim 1 wherein:

said data includes specialized hematogical data obtained by quantitative buffy coat analysis of blood in a sample; and

said means for outputting messages provides messages in human language.

9. An apparatus for the non-interactive, automatic interpretation of quantitative buffy coat results comprising:

data processing means which includes;

means for evaluating blood-derived parametric values, and

means for ascertaining a clinically important interval (CII) combination applicable to blood-derived parametric values from a listing a plural CII'"'"'s and producing output messages therefrom;

memory means for storing data and data-processing instructions to be executed by the data processing means;

means for entering data which represent the values of hematology parameters derived from a patient'"'"'s blood; and

means for outputting the messages, of hematologic/diagnostic significance, applicable to the patient;

wherein the memory means stores a data base and execution-instructions of an automatically interpreting hematology-diagnostic system which is suitable for operation upon the hematology parameters and their values as derived by quantitative buffy coat analysis;

the data base including;

a relatively large number of messages of hematologic diagnostic significance, each message being associated with a range of values for each of the hematology parameters each range of values constituting one CII, and;

a listing of the CII'"'"'s within which the blood-derived parametric values may lie, the listing including a series of consecutive CII numbers and a range of values and a descriptive phrase associated with each CII;

the stored execution-instructions causing the data processing means to evaluate the blood-derived parametric values and to retrieve from the memory means the one or more messages whose CII combinations apply to the blood-derived parametric values, wherein the one or more messages are provided in a form to permit the interpretation of the hematologic condition of the patient.

10. Non-interactive hematology-diagnostic apparatus employing expert-system technology, the apparatus comprising:

a computer/data-processor which is provided with;

a memory facility for storing data, and also data processing instructions to be executed by the data processor,

means for entering into the computer in one single entry-pass, a complete set of data for a given patient, including data which represent the values of hematology parameters, derived from that patient'"'"'s blood assay;

a central processing unit adapted to process the patient derived data upon entry via the entry means, as well as data stored in the memory facility, the unit including

means for evaluating blood-derived parametric values, and means for ascertaining a clinically important interval (CII) combination applicable to blood-derived parametric values from a listing of plural CII'"'"'s and producing output messages therefrom;

and a printer connected to the data processor, for printing out the messages of hematology-diagnostic significance, and applicable to that patient;

wherein the memory facility stores a data base, and execution-instructions of an automatically interpreting hematologic/diagnostic system, which is suitable for operation upon the hematology parameters, and their blood-derived values;

the data base including;

a relatively large number of messages of hematologic diagnostic significance, each message being associated with a range of values for each of the hematologic parameters, each range of values constituting one CII, and the messages being adapted for printout;

a listing of the CII'"'"'s within which the blood-derived parametric values may lie, the listing including a series of consecutive descriptive phrase associated with each CII; and

the stored execution-instructions including directions to the processor, to;

retrieve from the memory facility, and prepare for printout in one single printout pass, a complete set of messages applicable to the given patient, the one or more messages whose range combinations apply to the blood-derived parametric values, and

cause the printer to print out the prepared messages in one single printout pass.

11. The apparatus of claim 10 wherein the printout is a human language description of the hematologic condition of said patient.

12. A method of non-interactively interpreting hematology results, comprising:

entering data representing the values of hematology parameters derived from blood into a data processor which includes

stored plural messages of hematological diagnostic significance, each message being associated with a range of values for each of a plurality of hematology parameters, and being in a form to permit the interpretation of the hematologic condition applicable to its range, each range of values constituting one clinically important interval (CII) a stored listing of the CII'"'"'s within which the parametric values may lie, the listing including a series of consecutive CII numbers and a range of values and a descriptive phrase associated with each CII and stored execution instructions which effect evaluation of parametric values and the retrieval of one or more messages whose CII combinations apply to the parametric values;

evaluating the entered data by the stored instructions to retrieve messages applicable to the relevant CII'"'"'s; and

producing the applicable messages in sensible form.