Programmable band-pass amplifier for use with implantable medical device

• US 5,024,221 A
• Filed: 11/17/1987
• Issued: 06/18/1991
• Est. Priority Date: 05/17/1985
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Siemens Pacesetter, Inc. (Abbott Laboratories Incorporated)
• Inventors: Morgan, Wayne A.
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/121,547
• Time in Patent Office: 1,309 Days
• Field of Search: 128/419 PG, 128/903, 128/904, 128/696, 128/700, 330/9
• US Class Current: 607/10
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control
• CPC Class Codes: Y10S 128/903 Radio telemetry

Abstract

A switched-capacitor, band-pass, programmable amplifier is used as a sense amplifier in an implantable cardiac pacemaker. Switching means are used to switchably connect various capacitors to the same amplifier circuits. Clock generator means are used to generate clock signals that are used to control the rate at which the switching means operates. By programmably selecting the switching rate to be a desired value, the band-pass characteristics and gain of the sense amplifier may be varied. When a pacemaker stimulation pulse occurs, the band-pass characteristics and/or gain of the sense amplifier, may also be automatically varied to improve amplifier recovery time. The rate at which the capacitors are switchably connected to the amplifier circuits, may be selected remotely, thereby allowing the band-pass characteristics to be programmable.

Claims

1. A programmable implantable medical device comprising:

a pacemaker for generating stimulation pulses;

a pair of electrodes coupled to the pacemaker for sensing electrical signals developed therebetween and for delivering said stimulation pulses to a desired location;

programmable band-pass amplifier means coupled to said electrodes for sensing and processing electrical signals, said programmable band-pass amplifier means including;

an amplifier having an input terminal and an output terminal, said electrical signals sensed by said electrodes being applied to said input terminal, said amplifier causing said electrical signals to be amplified by a desired gain factor and presented at the output terminal of said amplifier,

capacitor means for coupling to the amplifier,

switching means for switchably coupling said capacitor means to said amplifier, said switching means limiting the electrical signals amplified by said gain factor to those electrical signals having a frequency that falls within a band of frequencies bounded by a lower cut-off frequency and an upper cut-off frequency, the upper and lower cut-off frequencies of said frequency band being controlled by the rate at which said capacitor means is switchably coupled to said amplifier by said switching means, said switching rate, in turn, being controlled by a clock signal applied to said switching means; and

clock signal generating means coupled to said switching means for generating said clock signal at one of a plurality of possible clock frequencies, said clock signal generating means responsive to a remotely telemetered signal for selecting one of the plurality of possible clock frequencies for controlling the rate at which said capacitor means is switchably coupled to said amplifier;

whereby the frequency band of said band-pass amplifier means can be changed to a desired value by remotely changing the frequency of the clock signal generated by said clock signal generating means.

2. The implantable medical device of claim 1 wherein said clock signal generating means includes means for changing the frequency of said clock signal simultaneously with the delivery of said stimulation pulses.

3. The implantable medical device of claim 1 wherein said capacitor means comprises a plurality of capacitors, said clock signal comprising a first clock signal and a second clock signal, said switching means comprising first switch means for switchably connecting a first of said plurality of capacitors to the input terminal of said amplifier in response to the first clock signal, and second switch means for switchably connecting a second of said plurality of capacitors to the output terminal of said amplifier in response to the second clock signal.

4. The implantable medical device of claim 3 wherein said clock signal generating means generates said first and second clock signals at the clock signal frequency but at a different phase, whereby the operation of said first and second switch means does not occur at the same time, but occurs in a sequence defined by the phase relationship of said first and second clock signals.

5. The implantable medical device of claim 1 wherein said amplifier comprises a first amplifier stage for setting one of the upper or lower cut-off frequencies of said frequency band, and a second amplifier stage for setting the other of the upper or lower cut-off frequencies of said frequency band, and wherein said capacitor means comprises a first stage capacitor and a second stage capacitor, and further wherein said first stage capacitor is switchably coupled to said first amplifier stage by said switching means, and said second stage capacitor is switchably coupled to said second amplifier stage by said switching means.

6. The implantable medical device of claim 1 including telemetry means for receiving a remotely telemetered signal and for generating a gain control signal in response to such remotely telemetered signal, and wherein said switching means includes gain switch means responsive to said gain control signal for selectively adjusting the gain factor of said amplifier.

7. A sensing amplifier for use in an implantable medical device, said implantable medical device generating prescribed event signals and including a pair of electrodes between which said prescribed event signals are carried and between which an electrical signal having a broad frequency spectrum may be developed, said sensing amplifier comprising:

means for coupling the pair of electrodes to the sensing amplifier;

a first capacitor;

first amplifier means coupled to said pair of electrodes for amplifying selected frequency components of the electrical signal developed between said pair of electrodes, said selected frequency components comprising those components of said electrical signal having a frequency less than a first specified frequency, said first specified frequency being determined by the rate at which said firsts capacitor is switchably connected to said first amplifier means;

clock generating means for generating first and second clock signals;

first switching means responsive to said first clock signal for switchably connecting said first capacitor to said first amplifier means at a first switching rate derived from said first clock signal, whereby said first clock signal comprises a first control parameter that defines said first specified frequency;

a second capacitor;

second amplifier means coupled to said pair of electrodes, said selected frequency components comprising those components of said electrical signal having a frequency greater than a second specified frequency, said second specified frequency being determined by the rate at which said second capacitor is switchably connected to said second amplifier means;

second switching means responsive to said second clock signal for switchably connecting said second capacitor to said second amplifier means at a second switching rate derived from said second clock signal, whereby said second clock signal comprises a second control parameter that defines said second specified frequency; and

means for serially connecting said first and second amplifier means, whereby only those frequency components of the electrical signal developed between said pair of electrodes above said second specified frequency and below said first specified frequency are amplified by the serial combination of said first and second amplifier.

8. The sensing amplifier of claim 7 wherein said first amplifier means includes a first stage having an input and an output and a second stage having an input and an output, each of said stages having a respective capacitor that is switchably connected between the output and input of the respective stage thereof at the first switching rate, said first amplifier means further including a plurality of gain capacitors that can be selectively connected within said first amplifier means in order to change the gain thereof.

9. The sensing amplifier of claim 7 further including threshold generating means for generating a high threshold level signal and low threshold voltage signal;

and comparison means coupled to the output of threshold generating means and said serial combination of said first and second amplifier means for generating a data output signal transition from a first voltage level to a second voltage level only when an output analog signal from the serial combination of the first and second amplifier means exceeds said high threshold level signal, and for generating a data output transition from the second voltage level to the first voltage level only when the output analog signal is less than said low threshold level signal.

10. The sensing amplifier of claim 7 further including synchronous switching means coupled to said clock generating means for switching the rates of said first and second clock signals simultaneously with a prescribed event signal generated within said implantable medical device, whereby the specified first and second frequencies of said sensing amplifier are changed upon the occurrence of said prescribed event signal.

11. The sensing amplifier of claim 10 wherein said implantable medical device comprises a pacemaker having means for delivering a stimulation pulse through said pair of electrodes, and further wherein said prescribed event comprises the delivery of the stimulation pulse by said pacemaker, whereby said synchronous switching means switches the specified first and second frequencies of said sensing amplifier at approximately the same time as a stimulation pulse is delivered by said stimulation pulse delivery means.

12. The sensing amplifier claim 11 further including blanking means coupled to said sensing amplifier for preventing electrical signals developed between said pair of electrodes from being coupled to said sensing amplifier for a prescribed time period subsequent to the delivery of said stimulation pulse by said stimulation pulse delivery means.

13. A programmable implantable medical device comprising:

a pair of electrodes for sensing signals developed therebetween and delivering simulation pulses generated by said implantable medical device;

amplifier means coupled to said electrodes for sensing and processing said developed signals, said amplifier means comprising;

a plurality of capacitors,

a first amplifier circuit,

first switching means responsive to a first select signal for connecting desired combinations of said plurality of capacitors to said first amplifier circuit,

second switching means responsive to a clock signal for connecting at least one of said plurality of capacitors to said first amplifier circuit at a frequency determined by said clock signal, and

said first amplifier circuit having a gain factor that is controlled by the particular combination of capacitors that are connected thereto by said first switching means, and a band-pass characteristic that is a function of the frequency at which said second switching means connects and disconnects said at least one of said plurality of capacitors thereto;

clock signal generating means for generating said clock signal at a frequency determined by a second select signal; and

telemetry means for receiving a remotely telemetered command signal and for selectively generating said first and second select signals in response to a received remotely telemetered command signal,

whereby the gain and band-pass characteristics of said amplifier within said implantable medical device can be remotely selected.

14. The programmable implantable medical device of claim 13 wherein said medical device comprises a pacemaker having means for generating a simulation pulse, and wherein said clock signal generating means includes selection means coupled to said stimulation pulse generating means for selecting a first frequency for said clock signal simultaneously with the generation of the stimulation pulse, and for selecting a second frequency for said clock signal a prescribed time after the generation of the simulation pulse.