Retrograde perfusion system, components and method
First Claim
Patent Images
1. A catheter comprising:
- cannula means having a proximal end, a distal end in fluid communication with a corporeal lumen, and a channel for communication of fluids between said distal and proximal ends, said cannula means being formed for positioning within said corporeal lumen and for connection to external means when positioned in said corporeal lumen;
balloon means attached to said cannula means proximate said distal end and operable between an inflated condition in which said balloon means substantially occludes said corporeal lumen and a deflated condition in which said balloon means is collapsed about said cannula means, said balloon means being sized and shaped to facilitate fluid flow therepast in said lumen when in said deflated condition;
connector means attached to said proximal end for connection to a fluid reservoir;
balloon inflating means associated with said cannula means for operating said balloon means between said inflated and deflated conditions, said balloon inflating means including a second channel formed in said cannula means and a port formed in said cannula means in fluid communication between said second channel and the interior of said balloon means; and
pressure sensing means to sense the pressure of fluids within said lumen and communicate signals reflective thereof at said proximal end, said pressure sensing means including a port formed in said cannula means between said balloon means and said distal end and a third channel formed in said cannula means in fluid communication with said port to communicate fluid pressure signals therethrough.
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Abstract
A retrograde perfusion system has a catheter and a driver to inject retroperfusate into the coronary sinus. The catheter has a balloon which is inflated and deflated to first occlude and then drain the coronary sinus. During occlusion, retroperfusate is injected under pressure by the driver which also operates the balloon all in accordance with a preselected program.
386 Citations
51 Claims
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1. A catheter comprising:
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cannula means having a proximal end, a distal end in fluid communication with a corporeal lumen, and a channel for communication of fluids between said distal and proximal ends, said cannula means being formed for positioning within said corporeal lumen and for connection to external means when positioned in said corporeal lumen; balloon means attached to said cannula means proximate said distal end and operable between an inflated condition in which said balloon means substantially occludes said corporeal lumen and a deflated condition in which said balloon means is collapsed about said cannula means, said balloon means being sized and shaped to facilitate fluid flow therepast in said lumen when in said deflated condition; connector means attached to said proximal end for connection to a fluid reservoir; balloon inflating means associated with said cannula means for operating said balloon means between said inflated and deflated conditions, said balloon inflating means including a second channel formed in said cannula means and a port formed in said cannula means in fluid communication between said second channel and the interior of said balloon means; and pressure sensing means to sense the pressure of fluids within said lumen and communicate signals reflective thereof at said proximal end, said pressure sensing means including a port formed in said cannula means between said balloon means and said distal end and a third channel formed in said cannula means in fluid communication with said port to communicate fluid pressure signals therethrough. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A catheter comprising:
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cannula means for communicating fluids between interior and exterior of a body, said cannula means having a distal end and a proximal end, said cannula means being sized in cross section to be positioned within a fluid transporting corporeal lumen and in length to extend from within the body to exterior thereof, and said cannula means having a first channel formed therein for communication of fluids between said distal end and said proximal end; a balloon secured to said cannula means proximate said distal end and operable between an inflated condition in which said balloon is expanded to substantially occlude said corporeal lumen and a deflated condition in which said balloon is collapsed about said cannula means, said balloon being formed of a thin material and to have a cigar-like shape in the inflated condition with a taper toward both the proximal and distal ends at an angle of about 25 to about 35 degrees as measured between the exterior surface of the cannula means and the outer surface of said balloon; connector means secured to said proximal end for connection to a fluid reservoir; and a second channel formed in said cannula means in fluid communication with the balloon for operation thereof. - View Dependent Claims (11)
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12. A retrograde perfusion catheter comprising:
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cannula means adapted to transport fluids from exterior the body to the coronary sinus region, said cannula means having distal and proximal ends and being sized to extend from exterior the body into a lumen of the coronary sinus region of the heart, said cannula means having a first channel formed therein for communication of said fluids into said coronary sinus region; balloon means secured to said cannula means proximate to said distal end and operable between an inflated condition in which said balloon means surrounds said cannula means and is expanded to an elongated cigar-like shape with a taper toward said proximal and distal ends at an angle from about 25 degrees to about 35 degrees as measured between the exterior surface of said cannula means and the outer surface of said balloon means to substantially occlude fluid flow in said lumen and to a deflated condition in which said balloon means is collapsed about said cannula means, said balloon means being sizes and shaped to facilitate fluid flow therepast in said lumen when in said deflated condition; connector means secured to said proximal end in fluid communication with said first channel for connection to a source of fluids; balloon inflation means connected to said cannula means for operating said balloon means between said inflated and deflated conditions, said balloon inflating means including a second channel formed in said cannula means in fluid communication with the interior of said balloon means; and pressure sensing means to sense the pressure of fluids within said lumen and communicate signals reflective thereof at said proximal end, said pressure sensing means including a port formed in said cannula means between said balloon means and said distal end and a third channel formed in said cannula means in fluid communication with said port to communicate fluid pressure signals therethrough. - View Dependent Claims (13, 14, 15)
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16. A retrograde perfusion driver for connection to a retrograde perfusion catheter for communicating fluids into a fluid transporting corporeal lumen, which retrograde perfusion catheter has a distal end with an inflatable balloon positioned proximate thereto and a proximal end for connection to said driver, said retrograde perfusion driver comprising;
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supply means in fluid communication with a said retrograde perfusion catheter to supply retroperfusate thereto and to supply operating signals to a said balloon positioned proximate the distal end of said retrograde perfusion catheter to cause said balloon to operate between an inflated condition and a deflated condition, said supply means including; source means connectable to said retrograde perfusion catheter for supplying retroperfusate under pressure to said retrograde perfusion catheter, said source means including a supply of retroperfusate and pump means with an inlet connected to said supply of retroperfusate and an outlet connected to said retrograde perfusion catheter, and balloon operation means for connection to said retrograde perfusion catheter to supply said operating signals thereto, said balloon operation means including an operating signal generator connected to said retrograde perfusion catheter for supplying said operating signals and actuation means positioned proximate said operating signal generator for operation thereof, and wherein said second control signals are supplied to said actuation means; control means for generating first and second control signals and connected to said supply means to supply said first control signals thereto to cause said source means to supply said retroperfusate under pressure, and connected to said balloon operation means to supply said second control signals thereto to cause supply of said operating signals, said first and second control signals being periodically generated in accordance with a preselected pattern. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A retrograde perfusion system comprising:
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a catheter for communicating retroperfusate into a corporeal lumen, said catheter being formed to be positioned through a corporeal vein and into a lumen in the coronary sinus region of the heart, said catheter having; a distal end and a proximal end, a first channel formed therein for communication of retroperfusate into said coronary sinus region, a balloon positioned about said catheter proximate said distal end and operable between an inflated condition in which said balloon is expanded to substantially occlude fluid flow in said lumen and a deflated condition in which said balloon is deflated about said catheter, said balloon being formed to have an elongated cigar-like shape with a taper toward said proximal end and toward said distal end each at an angle between about 25 degrees and about 35 degrees between the exterior surface of said catheter means and the outer surface of said balloon, a recess formed proximate said balloon wherein said balloon in said deflated condition has portions within said recess, and a second channel formed in said catheter in communication with the interior of said balloon; a source of retroperfusate; and a driver comprised of; a supply pump connected to said source of retroperfusate to receive retroperfusate therefrom and to said first channel to supply retroperfusate thereto and operable to pump the retroperfusate under pressure to and through said first channel into said lumen, balloon operation means connected to said second channel, said balloon operation means having a source of fluid and operable to supply and extract said fluid to and from said balloon through said second channel, control means conductively connected to said supply pump and said balloon operation means to supply control signals thereto, said control means having means to generate control signals to operate said supply pump and said balloon inflation means in accordance with a preselected program. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A retrovenous perfusion system comprising:
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a catheter for communicating retroperfusate into a corporeal lumen, said catheter being formed to be positioned through a corporeal vein and into a lumen in the coronary sinus region of the heart, said catheter having; a distal end and a proximal end, a first channel formed in said catheter for communication of retroperfusate into said coronary sinus region, a balloon secured to said catheter proximate said distal end and operable between an inflated condition in which said balloon is expanded to substantially occlude fluid flow in said lumen and a deflated condition in which said balloon is deflated about said catheter, a second channel formed in said catheter in communication with the interior of said balloon, a recess formed in said catheter proximate said balloon wherein said balloon in said deflated condition has portions within said recess, a third channel formed in said catheter in fluid communication with said lumen between said balloon and said proximal end, and wherein said balloon is formed to have elongated cigar-like shape with a taper toward said distal and proximal ends; a source of retroperfusate; a driver having; pressure sensing means connected to said third channel to sense the pressure of fluid therein and to generate signals reflective thereof, supply pump means connected to said first channel and to said source of retroperfusate to receive and to supply retroperfusate to said first channel under pressure, motor means associated with said supply pump means to operate said supply pump means, a pump comprised of a syringe with a plunger and having an outlet connected to said second channel and to a source of fluid and actuation means associated with said pump for operation thereof; control means conductively connected to receive said pressure reflective signals from said pressure sensing means to said solenoid valve means to supply control signals thereto and to said motor means to supply operation signals thereto, said control means having; first means to select a first preset signal reflective of a maximum pressure, means to receive said pressure reflective signal from said pressure sensing means, and means to compare said pressure reflective signal from said pressure sensing means to said first preset signal and to supply a control signal to said actuation to cause said actuation to operate said pump to deflate said balloon when the pressure reflective signal from said pressure sensing means exceeds said first preset signal, second means to select a second preset signal reflective of a minimum pressure, means to receive said pressure reflective signal from said pressure sensing means, and means to compare said pressure reflective signal from said pressure sensing means to said second preset signal and to supply a control signal to said actuation means to operate said pump to cause inflation of said balloon, timing means connected to said first means and said second means to measure the time said balloon is in a deflated condition and in an inflated condition and means associated with said timing means to select a first time for inflation and a second time for deflation, and wherein said timing means is connected to said actuation means to cause said actuation means to operate to cause said balloon to be placed in said deflated condition when said first time is measured and in said inflated condition when said second time is measured; and power supply means connected to supply electrical power to said control means. - View Dependent Claims (45, 46)
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47. A method of retrograde perfusion comprising:
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inserting a catheter into a corporeal lumen, said catheter having a distal end and a proximal end, a first channel formed therein for communication of fluids between said distal end and said proximal end, and a balloon positioned proximate said distal end; connecting a source of retroperfusate under pressure to said first channel; inflating said balloon with a fluid through a second channel formed in said catheter to occlude said lumen for a first preselected period of time; supplying said retroperfusate under pressure through said first channel into said lumen; deflating said balloon by extracting said fluid from said balloon through said second channel to place the balloon in a deflated condition collapsed about said catheter for a second preselected period of time; wherein said first preselected period of time is the first occurring of a preset time period of the attachment of a preselected pressure in said lumen proximate the said distal end; and wherein said second preselected period of time is the first occurring of a preset time period or the attainment of a preselected pressure in said lumen proximate the said distal end. - View Dependent Claims (48, 49)
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50. A catheter comprising:
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cannula means having a proximal end, a distal end in fluid communication with a corporeal lumen, and a channel for communication of fluids between said distal and proximal ends, said cannula means being sized and shaped for positioning within said corporeal lumen and for connection to external means when positioned in said corporeal lumen; a balloon secured to said cannula means proximate said distal end and operable between an inflated condition in which said balloon means substantially occludes said corporeal lumen and a deflated condition in which said balloon is collapsed about said cannula means, and forms a plurality of essentially spiral ribs along said cannula means; connector means secured to said proximal end for connection to a fluid reservoir; and balloon inflating means associated with said cannula means for operating said balloon means between said inflated and deflated conditions.
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51. A catheter comprising:
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cannula means having a proximal end, a distal end in fluid communication with a corporeal lumen, and a channel for communication of fluids between said distal and proximal ends, said cannula means being sized and shaped for positioning within said corporeal lumen and for connection to external means when positioned in said corporeal lumen; balloon means secured to said cannula means proximate said distal end and operable between an inflated condition in which said balloon means substantially occludes said corporeal lumen and a deflated condition in which said balloon means is collapsed about said cannula means, a recess formed in said cannula means proximate said balloon means, a portion of said balloon means being within said recess in said deflated condition; connector means secured to said proximal end for connection to a fluid reservoir; and balloon inflating means associated with said cannula means for operating said balloon means between said inflated and deflated conditions.
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Specification