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Annealed coats

  • US 5,024,842 A
  • Filed: 04/02/1990
  • Issued: 06/18/1991
  • Est. Priority Date: 04/28/1988
  • Status: Expired due to Term
First Claim
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1. A dosage form for delivering a drug to a fluid environment of use, the dosage form comprising:

  • (a) a wall comprising an annealed subcoat and overcoat, said subcoat and overcoat annealed at about 20°

    C. to 75°

    C. for about 5 to 90 hours; and

    wherein;

    (1) the subcoat comprises a member selected from the group consisting of a cellulose ether, a cellulose ester and a cellulose ester-ether emulsifiers which subcoat is permeable to the passage of fluid and maintains its physical and chemical integrity in fluid;

    (2) the overcoat comprising a member selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and methylcellulose, and wherein said overcoat loses its physical and chemical integrity in fluid;

    which wall surrounds;

    (b) a compartment;

    (c) a therapeutically effective amount of drug in the compartment; and

    (d) at least one passageway in the wall connecting the exterior with the interior of the device for delivering the drug over time.

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