Annealed coats

• US 5,024,842 A
• Filed: 04/02/1990
• Issued: 06/18/1991
• Est. Priority Date: 04/28/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Edgren, David E., Theeuwes, Felix
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): HORNE, LEON
• Application Number:
  US07/503,004
• Time in Patent Office: 442 Days
• Field of Search: 424/473, 424/489, 424/474, 424/472, 424/468, 424/469, 424/470
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/2866 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61K 9/2886 having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer of the type active core-drug layer-inactive layer A61K9/209

Abstract

A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.

Claims

1. A dosage form for delivering a drug to a fluid environment of use, the dosage form comprising:

(a) a wall comprising an annealed subcoat and overcoat, said subcoat and overcoat annealed at about 20°

C. to 75°

C. for about 5 to 90 hours; and

wherein;

(1) the subcoat comprises a member selected from the group consisting of a cellulose ether, a cellulose ester and a cellulose ester-ether emulsifiers which subcoat is permeable to the passage of fluid and maintains its physical and chemical integrity in fluid;

(2) the overcoat comprising a member selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and methylcellulose, and wherein said overcoat loses its physical and chemical integrity in fluid;

which wall surrounds;

(b) a compartment;

(c) a therapeutically effective amount of drug in the compartment; and

(d) at least one passageway in the wall connecting the exterior with the interior of the device for delivering the drug over time.

2. The dosage form according to claim 1, wherein the subcoat comprises an emulsifier selected from the group consisting of nonionic, amionic and cationic emulsifiers.