Annealed coats
First Claim
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1. A dosage form for delivering a drug to a fluid environment of use, the dosage form comprising:
- (a) a wall comprising an annealed subcoat and overcoat, said subcoat and overcoat annealed at about 20°
C. to 75°
C. for about 5 to 90 hours; and
wherein;
(1) the subcoat comprises a member selected from the group consisting of a cellulose ether, a cellulose ester and a cellulose ester-ether emulsifiers which subcoat is permeable to the passage of fluid and maintains its physical and chemical integrity in fluid;
(2) the overcoat comprising a member selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and methylcellulose, and wherein said overcoat loses its physical and chemical integrity in fluid;
which wall surrounds;
(b) a compartment;
(c) a therapeutically effective amount of drug in the compartment; and
(d) at least one passageway in the wall connecting the exterior with the interior of the device for delivering the drug over time.
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Abstract
A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.
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Citations
2 Claims
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1. A dosage form for delivering a drug to a fluid environment of use, the dosage form comprising:
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(a) a wall comprising an annealed subcoat and overcoat, said subcoat and overcoat annealed at about 20°
C. to 75°
C. for about 5 to 90 hours; and
wherein;(1) the subcoat comprises a member selected from the group consisting of a cellulose ether, a cellulose ester and a cellulose ester-ether emulsifiers which subcoat is permeable to the passage of fluid and maintains its physical and chemical integrity in fluid; (2) the overcoat comprising a member selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and methylcellulose, and wherein said overcoat loses its physical and chemical integrity in fluid;
which wall surrounds;(b) a compartment; (c) a therapeutically effective amount of drug in the compartment; and (d) at least one passageway in the wall connecting the exterior with the interior of the device for delivering the drug over time. - View Dependent Claims (2)
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Specification