Method of acquiring NMR angiograms in selected flow component directions

• US 5,025,788 A
• Filed: 03/22/1990
• Issued: 06/25/1991
• Est. Priority Date: 02/11/1987
• Status: Expired due to Fees

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Dumoulin, Charles L.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US07/497,290
• Time in Patent Office: 460 Days
• Field of Search: 128/653 A, 128/653 AF, 324/306, 324/309
• US Class Current: 600/413
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography

Abstract

Several sequences of radio-frequency and magnetic field gradients are presented for obtaining from a sample multiple response echo signals from which to obtain a plurality of independent angiograms, which can be combined or separately analyzed to provide more information than an individual angiogram, but in substantially the same amount of time as a single angiogram. For example, a series of angiograms, each with a different projection axis, can be obtained in the time required to obtain a single angiogram using a single echo method. If the view angle of each echo is the same, then the acquired angiograms can be added to enhance the signal-to-noise ratio. Another pulse sequence simultaneously obtains two or more angiograms, each sensitive to one of two orthogonal flow components of the overall blood flow; the angiograms are then added to give an angiogram which is sensitive to total flow in all directions. Multiple velocity ranges are accommodated in a fourth sequence form.

Claims

1. A method for acquiring at least one nuclear magnetic resonance (NMR) angiographic image of flowing material in at least a selected portion of a sample, comprising the steps of:

(a) immersing the sample in a main static magnetic field;

(b) nutating, in the initial part of each of a first sequence and a second sequence of a sequential pair of imaging sequences for each of a multiplicity S of regions of said selected sample portion, the spins of all nuclei of a selected species;

(c1) applying, prior to a first of a plurality N of response data acquisition time intervals in each sequence, a pair of alternating-polarity flow-encoding signal pulses in a first magnetic field gradient impressed upon the sample in a first one of a pair of flow-encoding directions;

(c2) applying, after the first response interval in each sequence and prior to a second response data acquisition time interval, another pair of alternating-polarity flow-encoding signal pulses which are the inverse of the pulse pair of step (c1) and are in the first magnetic field gradient in the same first one of the flow-encoding directions;

(c3) applying, prior to the second response interval in each sequence, a pair of alternating polarity flow-encoding signal pulses in the remaining one of the flow-encoding directions in a second magnetic field gradient substantially orthogonal to the first magnetic field gradient;

each of the flow-encoding pulses in the first sequence of each pair having a polarity opposite to the polarity of the like-positioned flow-encoding pulse in the second sequence of each pair;

each flow-encoding direction being selective to establish one axis of an associated NMR angiographic projection image in which a resulting NMR response echo signal from the spin of a moving nucleus differs from the NMR response echo signal resulting from the spin of a substantially stationary nucleus;

(d) acquiring, responsive to a readout magnetic field gradient impressed upon the sample in a direction substantially independent of the flow-encoding directions, a set of data from the NMR response echo signal evoked, from at least the sample portion, in each different one of the plurality N of response data acquisition time intervals of each of the first and second sequences;

(e) subtracting the data in each first and second sets of data from the NMR response echo signal evoked in the first sequence, from the data in the like-numbered data set of the second sequence, to generate a respective first one I_A and a second one I_B of a pair of difference data sets from which response data obtained from stationary nuclei has been substantially removed; and

(f) processing the difference data I_A set in the first direction and the difference data I_B set in the second direction to obtain a final difference data set I_t having a value given to I_t =((I_A)² +(I_B)²)^1/2, to display a total-flow angiogram.

2. The method of claim 1, wherein steps (c2) and (c3) occur substantially simultaneously.

3. The method of claim 1, wherein step (d) further includes the steps of:

generating a dephasing pulse in the readout gradient prior to each of the N response data acquisition time intervals in each sequence;

generating a rephasing pulse in the readout gradient after the first response acquisition time interval in each sequence; and

providing the rephasing pulse with substantially the same amplitude as the substantially equal amplitudes of the two dephasing pulses in that sequence.

4. The method of claim 3, wherein step (d) further comprises the step of applying a projection-dephasing gradient signal pulse in a direction substantially orthogonal to the readout gradiant direction, substantially simultaneous with the first readout gradient dephasing pulse to enhance suppression by limiting the dynamic range of the response signals evoked from the nuclei with substantially stationary spins.

5. The method of claim 4, wherein the first direction is the direction of the main static field, and the two different second directions both are in a plane orthogonal thereto.

6. The method of claim 1, wherein step (d) includes the steps of:

providing a phase-encoding pulse in a magnetic field gradient in a direction orthogonal to the readout gradient direction; and

assigning, in each pair of sequences, one of the multiplicity S of different values thereto.

7. The method of claim 1, wherein step (b) includes the step of limiting the nutating action to a predetermined volume of the sample portion.

8. The method of claim 1, wherein the sample is a portion of a living entity having a cardiac cycle, and further including the step of gating the commencement of each sequence with respect to a designated point in the cardiac cycle of the entity.