Dosimetric technique for stereotactic radiosurgery same

• US 5,027,818 A
• Filed: 05/18/1989
• Issued: 07/02/1991
• Est. Priority Date: 12/03/1987
• Status: Expired due to Term

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida (State University System of Florida)
• Inventors: Bova, Frank J., Friedman, William A.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Pfaffle, Krista M.
• Application Number:
  US07/353,816
• Time in Patent Office: 775 Days
• Field of Search: 128/653 R, 128/654, 128/659, 378/65, 606/130, 364/413.14, 364/413.15, 364/413.16, 364/413.22, 364/413.26
• US Class Current: 600/427
• CPC Class Codes: A61B 2017/00707 Dummies, phantoms; Devices simulating patient or parts of patient
• CPC Class Codes: A61B 2017/00712 simulating mathematical properties, e.g. for testing of positioning in the isocentre or focus
• CPC Class Codes: A61B 2090/101 for stereotaxic radiosurgery
• CPC Class Codes: A61B 2090/363 Use of fiducial points
• CPC Class Codes: A61B 6/506 for diagnosis of nerves
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: A61N 5/1031 using a specific method of dose optimization
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam

Abstract

Stereotactic radiosurgery is facilitated by a technique for computing the doses at various points within the patient'"'"'s body. In particular, the doses are computed at a relatively high density of points within a fine dose grid and at a relatively low density of points within a coarse dose grid. In that fashion, the user can quickly obtain necessary information about the radiation dose distribution before implementation of a proposed treatment plan. An advantageous technique of locating the intersection between the radiation beam and the contour or other surface of the patient is also provided. The method is especially well suited for use with a particular structure which allows one to utilize relatively narrow beam widths as a result of great mechanical accuracy.

Claims

1. A method for patient care comprising the steps of:

(a) localizing a target within a patient;

(b) subjecting the patient to an imaging system with a display to generate patient reference data in the form of x,y,z coordinates of the target and adjacent portions of the patient;

(c) supplying the patient reference data to a dosimetric computer connected to said display;

(d) inputting into the dosimetric computer a proposed plan for applying at least one beam of radiation to the patient from at least one source and from at least two different directions;

(e) selecting a plane of the patient for display of a distribution of radiation which would result from the proposed plan;

(f) displaying on said display a selected plane patient image corresponding to the selected plane by operation of the imaging system;

(g) determining the distribution of radiation within the selected plane by calculating the radiation dose at points spaced by distance D1 within a fine dose grid relatively close to the target and calculating the radiation dose at points spaced by distance D2, greater than D1, within a coarse dose grid outside said fine dose grid, the dosimetric computer performing the calculations for the radiation dose at a greater density of points in the fine dose grid and at a lower density of points in the coarse dose grid; and

(h) displaying data on the display from the radiation dose calculations.

2. The method of claim 1 wherein some data resulting from the radiation dose calculations is placed on the patient image in the display.

3. The method of claim 2 wherein the proposed plan includes at least a first arc through which the beam is applied to the patient, said first arc being in a first arc plane, and wherein said inputting step includes the substeps of:

selecting the first arc plane;

displaying a first arc plane patient image corresponding to the first arc plane on the display;

creating a bit map of pixels on the display to said x,y,z coordinates of the patient reference data;

identifying each pixel which makes up an outside contour of the patient;

storing the beginning and end of the first arc;

drawing a line between the source at a given location and an isocenter within the target;

finding the intersection pixel of the line and the pixels corresponding to the outside contour;

referencing the bit map to identify the x,y,z coordinates of the intersection pixel as a beam entrance point;

repeating the drawing, finding, and referencing substeps to identify additional beam entrance points corresponding to different source locations; and

storing the beam entrance points, these beam entrance points corresponding to the center of the beam at different source locations.

4. The method of claim 3 wherein the stored beam entrance points are used to perform the radiation dose calculations.

5. The method of claim 4 wherein the radiation dose calculations are performed for each of said different source locations based on radiation entering only at said beam entrance points such that edge effects are ignored.

6. The method of claim 5 wherein the width of each beam used in the proposed plan is less than 5 cm such that ignoring edge effects will not introduce substantial errors.

7. The method of claim 6 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

8. The method of claim 4 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

9. The method of claim 1 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

10. A method for patient care comprising the steps of:

(a) localizing a target within a patient;

(b) subjecting the patient to an imaging system with a display to generate patient reference data in the form of x,y,z coordinates of the target and adjacent portions of the patient;

(c) supplying the patient reference data to a dosimetric computer connected to said display;

(d) inputting into the dosimetric computer a proposed plan for applying at least one beam of radiation to the patient from at least one source and from at least two different directions;

wherein the proposed plan includes at least a first arc through which the beam is applied to the patient, said first arc being in a first arc plane, and wherein said inputting step includes the substeps of;

selecting the first arc plane;

displaying a first arc plane patient image corresponding to the first arc plane on the display;

creating a bit map of pixels on the display to said x,y,z coordinates of the patient reference data;

identifying each pixel which makes up an outside contour of the patient;

storing the beginning and end of the first arc;

drawing a line between the source at a given location and an isocenter within the target;

finding the intersection pixel of the line and the pixels corresponding to the outside contour;

referencing the bit map to identify the x,y,z coordinates of the intersection pixel as a beam entrance point;

repeating the drawing, finding, and referencing substeps to identify additional beam entrance points corresponding to different source locations; and

storing the beam entrance points, these beam entrance points corresponding to the center of the beam at different source locations.

11. The method of claim 10 further comprising:

selecting a plane of the patient for display of a distribution of radiation which would result from the proposed plan;

displaying on said display a selected phase patient image corresponding to the selected plane by operation of the imaging system;

determining the distribution of radiation within the selected plane; and

displaying data on the display resulting from the distribution determination.

12. The method of claim 11 wherein the determination of the distribution is accomplished by calculating the radiation dose at points spaced by distance D1 within a fine dose grid relatively close to the target and calculating the radiation dose at points spaced by distance D2, greater than D1 within a coarse dose grid outside said fine dose grid;

the dosimetric computer performing the calculations for the radiation dose at a greater density of points in the fine dose grid and at a lower density of points in the coarse does grid.

13. The method of claim 12 wherein the stored beam entrance points are used to perform the radiation dose calculations.

14. The method of claim 13 wherein the radiation dose calculations are performed for each of said different source locations based on radiation entering only at said beam entrance points such that edge effects are ignored.

15. The method of claim 14 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

16. The method of claim 15 wherein the beam or beams applied to the patient are less than 5 cm in width.

17. The method of claim 10 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

18. The method of claim 17 wherein the beam or beams applied to the patient are less than 5 cm in width.

19. A method for patient care comprising the steps of:

(a) localizing a target within a patient;

(b) subjecting the patient to an imaging system with a display to generate patient reference data in the form of x,y,z coordinates of the target and adjacent portions of the patient;

(c) supplying the patient reference data to a dosimetric computer connected to said display;

(d) inputting into the dosimetric computer a proposed plan for applying at least one beam of radiation to the patient from at least one source and from at least two different directions;

(e) selecting a plane of the patient for display of a distribution of radiation which would result from the proposed plan;

(f) displaying on said display a patient image corresponding to the selected plane by operation of the imaging system;

(g) determining the distribution of radiation within the selected plane by calculating the radiation dose at points spaced by distance D1 within a fine dose grid relatively close to the target and calculating the radiation dose at points spaced by distance D2, greater than D1, within a coarse dose grid outside said fine dose grid, the dosimetric computer performing the calculations for the radiation dose at a greater density of points in the fine dose grid and at a lower density of points in the coarse dose grid; and

(h) outputting data from the radiation dose calculations.

20. The method of claim 19 further comprising the step of subjecting the patient to radiation in accord with the proposed plan using a stereotactic radiosurgery apparatus comprising:

a gantry supported for rotation about a gantry axis, the gantry having a radiation-emitting head for movement in an arc in a radiation plane about a center point corresponding to an intersection of the gantry axis and the radiation plane, said gantry axis being normal to said radiation plane;

a collimator disposed to focus radiation from said radiation-emitting head on said center point; and

collimator linking means for linking movement of said collimator to said radiation-emitting head for automatic rotation of said collimator in said radiation plane and about said gantry axis upon rotation of said gantry, said collimator linking means allowing said collimator to track rotation of said gantry with no or minimal transfer of positioning inaccuracies from said gantry to said collimator.