Medical apparatus for stimulating a physiological event in a patient with a stimulation intensity automatically adapted to the physical activity of the patient and a method for adapting the stimulation intensity to the physical activity of the patient

• US 5,029,582 A
• Filed: 02/09/1990
• Issued: 07/09/1991
• Est. Priority Date: 02/10/1989
• Status: Expired due to Term

• Current Assignee: Pacesetter AB (Abbott Laboratories)
• Original Assignee: Siemens AG
• Inventors: Lekholm, Anders
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US07/478,228
• Time in Patent Office: 515 Days
• Field of Search: 128/419 PG, 128/736
• US Class Current: 607/21
• CPC Class Codes: A61N 1/3655 controlled by body or blood temperature

Abstract

A medical apparatus for stimulating a physiological event in a patient, with the stimulation intensity being automatically adapted to the physical activity of the patient, includes respective sensors for monitoring the chronological curves of the temperature within the patient and at the body periphery of the patient. These temperature curves are used as a basis for determining the activity level of the patient, and for setting the stimulation intensity in accordance with that physical activity.

Claims

1. A medical apparatus implantable in the body of a patient comprising:

means for stimulating a physiological event in a patient at a stimulation intensity;

first sensor means for measuring the temperature in the interior of s id patient and generating a first temperature signal corresponding thereto;

second sensor means for measuring the temperature in the region of the periphery of said patient and generating a second temperature signal corresponding thereto; and

means connected to said means for stimulating and to said first and second sensor means for modifying said stimulation intensity to adapt said stimulation intensity to the physical activity level of said patient, including means for determining a chronological sequence of changes respectively occurring in said first and second temperature signals for use as a basis for modifying said stimulation intensity.

2. A medical apparatus as claimed in claim 1, wherein each of said first and second temperature signals has a slope having an operational sign, and wherein said means for modifying said stimulation intensity further includes means for identifying the operational sign of the slope of at least one of said first and second temperature signals for use as a further basis for modifying said stimulation intensity.

3. A medical apparatus as claimed in claim 1, wherein each of said first and second temperature signals has a slope having a magnitude, and wherein said means for modifying said stimulation intensity further includes means for identifying the magnitude of the slope of at least one of said first and second temperature signals for use as a further basis for modifying said stimulation intensity.

4. A medical apparatus as claimed in claim 1, wherein each of said first and second temperature signals has a slope having an operational sign, and wherein said means for setting the stimulation frequency includes means for identifying the operational sign of the slope of both said first and second temperature signals for use as a further basis for modifying said stimulation intensity.

5. A medical apparatus as claimed in claim 1, wherein said apparatus is a heart pacemaker, wherein said means for stimulating a physiological event in said patient at a stimulation intensity is a means for stimulating heart activity at a stimulation frequency, and wherein said means for modifying said stimulation intensity is a means for modifying said stimulation frequency.

6. A medical apparatus as claimed in claim 5, wherein said pacemaker has a pacemaker housing, wherein said means for stimulating heart activity includes a lead extending from said housing and terminating in a free end having an electrode adapted for anchoring in the right ventricle of the heart of said patient, wherein said first sensor means includes a first temperature sensor disposed at said free end of said lead for measuring the blood temperature present in the right ventricle, and wherein said second sensor means includes a second temperature sensor mounted in said housing of said pacemaker.

7. A medical apparatus as claimed in claim 1, further comprising:

a housing having first and second spaced wall sections disposed opposite each other and wherein said housing is adapted for implantation in the body of said patient with said first wall section facing the periphery of said patient and said second wall section facing the interior of said patient, and wherein said first sensor means is mounted at said first wall section and said second sensor means is mounted at said second wall section.

8. A medical apparatus implantable in the body of a patient comprising:

means for stimulating a physiological event in a patient at a stimulation intensity;

first sensor means for measuring the temperature in the interior of said patient and generating a first temperature signal corresponding thereto, said first temperature signal having a slope with an operational sign;

second sensor means for measuring the temperature in the region of the periphery of said patient and generating a second temperature signal corresponding thereto, said second temperature signal having a slope with an operational sign; and

means connected to said means for stimulating and to said first and second sensor means for modifying said stimulation intensity to adapt said stimulation intensity to the physical activity level of said patient, including means for identifying the operational sign of the slope of at least one of said first and second temperature signals for use as a basis for modifying said stimulation intensity and including means for determining the difference between said first and second temperature signals and for determining whether said difference upwardly or downwardly transgresses a normal value of said difference for use as a further basis for modifying said stimulation intensity.

9. A medical apparatus as claimed in claim 8, wherein the respective slopes of said first and second temperature signals each have a magnitude, and wherein said means for modifying said stimulation intensity further includes means for identifying the magnitude of the slope of at least one of said first and second temperature signals for use as a further basis for modifying said stimulation intensity.

10. A medical apparatus as claimed in claim 8, wherein said means for setting the stimulation frequency includes means for identifying the operational sign of the slope of both said first and second temperature signals for use in modifying said stimulation intensity.

11. A medical apparatus as claimed in claim 8, wherein said apparatus is a heart pacemaker, wherein said means for stimulating a physiological event in said patient at a stimulation intensity is a means for stimulating heart activity at a stimulation frequency, and wherein said means for modifying said stimulation intensity is a means for modifying said stimulation frequency.

12. A medical apparatus as claimed in claim 11, wherein said pacemaker has a pace maker housing, wherein said means for stimulating heart activity includes a lead extending from said housing and terminating in a free end having an electrode adapted for anchoring in the right ventricle of the heart of said patient, wherein said first sensor means includes a first temperature sensor disposed at said free end of said lead for measuring the blood temperature present in the right ventricle, and wherein said second sensor means includes a second temperature sensor mounted in said housing of said pacemaker.

13. An medical apparatus as claimed in claim 8, further comprising:

a housing having first and second spaced wall sections disposed opposite each other and wherein said housing is adapted for implantation in the body of said patient with said first wall section facing the periphery of said patient and said second wall section facing the interior of said patient, and wherein said first sensor means is mounted at said first wall section and said second sensor means is mounted at said second wall section.

14. A method comprising the steps of:

stimulating a physiological event in a patient at a stimulation intensity;

measuring the temperature in the interior of said patient and generating a first temperature signal corresponding thereto;

measuring the temperature in the region of the periphery of said patient and generating a second temperature signal corresponding thereto;

determining a chronological sequence of changes respectively occurring in said first and second temperature signals; and

modifying said stimulation intensity to adapt said stimulation intensity to the physical activity level of the patient based on said chronological sequence of changes.

15. A method as claimed in claim 14, wherein each of said first and second temperature signals has a slope having an operational sign, said method comprising the additional steps of:

identifying the operational sign of the slope of at least one of said first and second temperature signals; and

using said operational sign of the slope of said at least one of said first and second temperature signals as a further basis for modifying said stimulation intensity.

16. A method as claimed in claim 14, wherein the said first and second temperature signals each have a slope having a magnitude, and wherein said method further comprises the steps of:

identifying the magnitude of the slope of at least one of said first and second temperature signals; and

using said magnitude of the slope of said at least one of said first and second temperature signals as a further basis for modifying said stimulation intensity.

17. A method as claimed in claim 14, wherein each of said first and second temperature signals has a slope having an operational sign, and said method further comprising the

identifying the operational sign of the respective slopes of said first and second temperature signals;

and

using the operational sign of the respective slopes of both of said first and second temperature signals as a further basis for modifying said stimulation intensity.

18. A method comprising the steps of:

stimulating a physiological event in a patient at a stimulation intensity;

measuring the temperature in the interior of said patient and generating a first temperature signal corresponding thereto having a slope with an operational sign;

measuring the temperature in the region of the periphery of said patient and generating a second temperature signal corresponding thereto having a slope with an operational sign;

identifying the operational sign of the slope of at least one of said first and second temperature signals;

forming a difference signal between said first and second temperature signals, said difference signal having a normal value;

determining if said difference signal upwardly or downwardly transgresses said normal value; and

modifying said stimulation intensity to adapt to said stimulation intensity to the physical activity level of said patient based on said operational sign of said at least one of said first and second temperature signals and on whether said difference signal upwardly or downwardly transgresses said normal value.

19. A method as claimed in claim 18, wherein the respective slopes of said first and second temperature signals each has a magnitude, and wherein said method further comprises the steps of:

identifying the magnitude of the slope of at least one of said first and second temperature signals; and

using said magnitude of the slope of said at least one of said first and second temperature signals as a further basis for modifying said stimulation intensity.

20. A method for pacing a heart comprising the steps of:

stimulating the heart muscle activity in a patient at a stimulation frequency;

measuring the temperature in the interior of said patient and generating a first temperature signal corresponding thereto;

measuring the temperature in the region of the periphery of said patient and generating a second temperature signal corresponding thereto;

determining a chronological sequence of changes respectively occurring in said first and second temperature signals; and

modifying said stimulation frequency to adapt said stimulation frequency to the physical activity level of the patient based on said chronological sequence of changes in said first and second temperature signals.

21. A method as claimed in claim 20, wherein the step of stimulating heart activity is further defined as stimulating ventricular contractions in the heart at a stimulation frequency.

22. A method as claimed in claim 20, wherein the step of measuring the temperature in the interior of said patient is further defined as measuring the temperature of the venous blood of said patient.

23. A method as claimed in claim 22, wherein the step of measuring the venous blood of said patient is further defined as measuring the temperature of the venous blood of said patient in the right ventricle.

24. A method as claimed in claim 20, wherein each of said first and second temperature signals has a slope having an operational sign, said method further comprising the steps of:

identifying the operational sign of the slope of at least one of said first and second temperature signals; and

using the operational sign of the slope of said at least one of said first and second temperature signals as a further basis for modifying said stimulation frequency.

25. A method as claimed in claim 24, wherein the respective slopes of said first and second temperature signals each has a magnitude, and wherein said method further comprises the steps of:

identifying the magnitude of the slope of at least one of said first and second temperature signals; and

using said magnitude of the slope of said at least one of said first and second temperature signals as a further basis for modifying said stimulation intensity.

26. A method for pacing a heart comprising the steps of:

stimulating heart activity in a patient at a stimulation frequency;

measuring the temperature in the interior of said patient and generating a first temperature signal corresponding thereto having a slope with an operational sign;

measuring the temperature in the region of the periphery of said patient and generating a second temperature signal corresponding thereto having a slope with an operational sign;

identifying the operational sign of the slope of at least one of said first and second temperature signals;

determining the difference between said first and second temperature signals, said difference having a normal value;

determining whether said difference upwardly or downwardly transgresses said normal value; and

modifying said stimulation frequency based on said operational sign of the slope of said at least one of said first and second temperature signals and on whether said difference upwardly or downwardly transgresses said normal value.

27. A method as claimed in claim 26, wherein the step of measuring the temperature in the interior of said patient is further defined as measuring the temperature of the venous blood of said patient.

28. A method as claimed in claim 27, wherein the step of measuring the temperature of the venous blood of said patient is further defined as measuring the temperature of the venous blood in the right ventricle of said patient.

29. A heart pacemaker comprising:

a housing;

means for stimulating heart activity in said patient at a stimulation frequency;

first sensor means for measuring the temperature at a location in the interior of said patient remote from said housing and generating a first temperature signal corresponding thereto, said first sensor means including a lead extending from said housing to said remote location;

second sensor means mounted in said housing for measuring the temperature in the region of the periphery of said patient and generating a second temperature signal corresponding thereto; and

means connected to said means for stimulating and to said first and second sensor means for modifying said stimulation frequency to adapt said stimulation frequency to the physical activity level of the patient including means for determining a chronological sequence of changes respectively occurring in said first and second temperature signals for use as a basis for modifying said stimulation frequency.

30. A heart pacemaker as claimed in claim 29, wherein said means for stimulating heart activity includes an electrode disposed in the right ventricle of said heart of said patient, wherein said first sensor means includes a blood temperature sensor disposed in said right ventricle having an electrical connection via said lead to an interior of said housing, and wherein said electrode is electrically connected to said means for stimulating via said lead of said first sensor means.

31. A heart pacemaker as claimed in claim 30, wherein said means for stimulating heart activity includes an electrode disposed in the right ventricle of said heart of said patient, wherein said first sensor means includes a blood temperature sensor disposed in aid right ventricle having electrical connection via said lead to an interior of said housing, and wherein said electrode is electrically connected to said means for stimulating via said lead of said first sensor means.

32. A heart pacemaker comprising:

a housing;

means for stimulating heart activity in a patient at a stimulation frequency;

first sensor means for measuring the temperature at a location in the interior of said patient remote from said housing and generating a first temperature signal corresponding thereto, said first temperature signal having a slope with an operational sign;

second sensor means disposed in said housing for measuring the temperature in the region of the periphery of said patient and generating a second temperature signal corresponding thereto, said second temperature signal having a slope with an operational sign; and

means connected to said means for stimulating and to said first and second sensor means for modifying said stimulation frequency to adapt said stimulation frequency to the physical activity level of said patient, including means for identifying the operational sign of the slope of at least one of said first and second temperature signals for use as a basis for modifying said stimulation intensity and including means for determining the difference between said first and second temperature signals and for determining whether said difference upwardly or downwardly transgresses a normal value of said difference for use as a further basis for modifying said stimulation frequency.

33. A heart pacemaker comprising:

a housing having a first wall adapted, when said housing is implanted in a patient, to be facing the interior of said patient and having a second wall adapted to be facing the body periphery of said patient;

means for stimulating heart activity in said patient at a stimulation frequency;

first sensor means mounted at said first wall for measuring the temperature in the interior of said patient and generating a first temperature signal corresponding thereto;

second sensor means mounted at said second wall for measuring the temperature in the region of the periphery of said patient and generating a second temperature signal corresponding thereto; and

means connected to said means for stimulating and to said first and second sensor means for modifying said stimulation frequency to adapt said stimulation frequency to the physical activity level of said patient, including means for determining a chronological sequence of changes respectively occurring in said first and second temperature signals for use as a basis for modifying said stimulation frequency.

34. A heart pacemaker comprising:

a housing having a first wall adapted, when said housing is implanted in a patient, to be facing the interior of said patient and having a second wall adapted to be facing the body periphery of said patient;

means for stimulating heart activity in said patient at a stimulation frequency;

first sensor means mounted at said first wall for measuring the temperature in the interior of said patient and generating a first temperature signal corresponding thereto, said first temperature signal having a slope with an operational sign;

second sensor means mounted at said second wall for measuring the temperature in the region of periphery of said patient and generating a second temperature signal corresponding thereto, said second temperature signal having a slope with an operational sign; and

means connected to said means for stimulating and to said first and second sensor means for modifying said stimulation frequency to adapt said stimulation frequency to the physical activity level of said patient, including means for identifying the operational sign of the slope of at least one of said first and second temperature signals for use as a basis for modifying said stimulation frequency and including means for determining the difference between said first and second temperature signals and for determining whether said difference upwardly or downwardly transgresses a normal value of said different for use as a further basis for modifying said stimulation intensity.