Dispensing devices powered by lyotropic liquid crystals

• US 5,030,452 A
• Filed: 01/12/1989
• Issued: 07/09/1991
• Est. Priority Date: 01/12/1989
• Status: Expired due to Fees

• Current Assignee: Pfizer Inc.
• Original Assignee: Pfizer Inc.
• Inventors: Curatolo, William J.
• Primary Examiner(s): Cashion, Jr., Merrell C.
• Assistant Examiner(s): Prater, P. L.
• Application Number:
  US07/296,458
• Time in Patent Office: 908 Days
• Field of Search: 424/450, 424/463, 424/451, 424/452, 424/473, 264/4.6, 428/1
• US Class Current: 424/450
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by lyotropic liquid crystals. This inventioin also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such lyotropic liquid crystal powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprise administering to or otherwise placing the devices of this invention in the environment of use.

Claims

1. A dispensing device for the controlled delivery of a beneficial agent comprising a drug or mixtures thereof which comprises:

(a) an innermost layer comprising lyotropic liquid crystals;

(b) an outermost layer adjacent to and surrounding the innermost layer and comprising a mixture of one or more beneficial agents and lyotropic liquid crystals; and

(c) a water permeable polymer coating containing a plurality of pores which coating surrounds the outermost layer;

wherein said controlled delivery is effected by swelling of said lyotropic liquid crystals.

2. The dispensing device according to claim 1 wherein the innermost layer additionally comprises an osmotically effective solute.

3. The dispensing device according to claim 1 wherein the outermost layer additionally comprises an osmotically effective solute.

4. The dispensing device according to claim 1 wherein the innermost and outmost layers each additionally comprise an osmotically effective solute.

5. The dispensing device according to claim 1 wherein the coating additionally contains at least one hole.

15. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 1 into the environment of use.

6. A dispensing device for the controlled delivery of a beneficial agent comprising a drug or mixtures thereof which comprises:

(a) an innermost layer comprising lyotropic liquid crystals;

(b) an outermost layer adjacent to and surrounding the innermost layer and comprising a mixture of one or more beneficial agents and lyotropic liquid crystals; and

(c) a water permeable polymer coating which surrounds the outermost layer and which comprises a polymer and one or more porosigens;

wherein said controlled delivery is effected by swelling of lyotropic liquid crystals.

7. The dispensing device according to claim 6 wherein the innermost layer additionally comprises an osmotically effective solute.

8. The dispensing device according to claim 6 wherein the outermost layer additionally comprises an osmotically effective solute.

9. The dispensing device according to claim 6 wherein the innermost and outermost layers each additionally comprise an osmotically effective solute.

10. The dispensing device according to claim 6 wherein the coating additionally contains at least one hole.

16. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 6 into the environment of use.

18. A capsule which comprises a water soluble wall and one or more devices of claim 6.

19. A method for the controlled delivery of a drug to an animal which comprises administering to the animal the device according to claim 18 wherein the beneficial agent is a drug.

11. A dispensing device for the controlled delivery of a beneficial agent comprising a drug or mixtures thereof which comprises:

(a) an innermost layer comprising lyotropic liquid crystals;

(b) an outermost layer adjacent to and surrounding the innermost layer and comprising a mixture of one or more beneficial agents and lyotropic liquid crystals; and

(c) a water permeable polymer coating containing at least one hole which coating surrounds the outermost layer;

wherein said controlled delivery is effected by swelling of lyotropic liquid crystals.

12. The dispensing device according to claim 11 wherein the innermost layer additionally comprises an osmotically effective solute.

13. The dispensing device according to claim 11 wherein the outermost layer additionally comprises an osmotically effective solute.

14. The dispensing device according to claim 11 wherein the innermost and outermost layers each additionally comprise an osmotically effective solute.

17. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 11 into the environment of use.