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Cytotoxic antibody conjugates and a process for preparation thereof

  • US 5,030,719 A
  • Filed: 04/27/1988
  • Issued: 07/09/1991
  • Est. Priority Date: 08/28/1986
  • Status: Expired due to Fees
First Claim
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1. Cytotoxic antibody conjugates wherein an antibody or its fragment which binds to antigenic cells is bound to a folic acid-antagonistic folic acid analgogue through an oligopeptide, wherein said cytotoxic antibody conjugate is represented by general formula (I)(R'"'"'--CO--NH--Y--CO--NHNHCOCH.sub. 2 --NH) Ab (I)where R'"'"' represents, together with CO, the residual group of a folic acid-antagonistic folic acid analogue, --NH--Y--CO--represents the residual group of an oligopeptide containing L-leucyl-L-alanyl-L-leucine, Ab represents an antibody or its fragment which bends to antigenic cells, and the N-atom adjacent to Ab is the nitrogen atom originating from the antibody or its fragment, and n is an integer of from 1 to 30.

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