Pacemaker rate control using amplitude and frequency of activity signal

• US 5,031,614 A
• Filed: 05/21/1990
• Issued: 07/16/1991
• Est. Priority Date: 09/12/1986
• Status: Expired due to Term

• Current Assignee: Advanced Medical Optics Incorporated (Johnson & Johnson)
• Original Assignee: Intermedics Incorporated (Boston Scientific Corporation)
• Inventors: Alt, Eckhard
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/525,768
• Time in Patent Office: 421 Days
• Field of Search: 128/419 PG, 128/782
• US Class Current: 607/19
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A variable rate pacemaker responsive to patient exercise senses physical activity of the patient by motion detection and generates a corresponding electrical signal. The pacemaker circuitry detects maximum and minimum values of the amplitude of the electrical signal in equal intervals of time. These time intervals are selected to be shorter than the shortest possible interval between repetitions or of the cycle representing speed of the physical activity. Only one parameter is calculated, namely the difference in maximum and minimum amplitude within each time interval, to determine both the amplitude of the signal corresponding to intensity of the exercise and, indirectly, the frequency of the signal corresponding to exercise speed and repetition rate, for use in pacemaker rate control. In a specific embodiment, the data of successive time intervals is averaged into data blocks, and a first-in, first-out technique is applied to the averaged data blocks for use in the desired pacing rate control.

Claims

1. An implantable variable rate pacemaker adaptive to patient exercise, comprising

means for detecting movements of the patient,

means responsive to the detection of such movements for discriminating between those of the detected movements which arise from physical exercise by the patient and those of the detected movements which are unrelated to physical exercise,

means responsive to such discrimination of the detected movements for generating an electrical signal representative of the detected movements which arise from physical exercise,

means responsive to said electrical signal for sampling thereof in successive predetermined equal intervals of time to determine from each sample the maximum and minimum values of the amplitude of said signal in each interval, and

means responsive to such determination of the maximum and minimum values of amplitude for ascertaining therefrom both the magnitude and the relative frequency of the detected movements which arise from physical exercise, to control the rate of said pacemaker according to both the ascertained magnitude and relative frequency.

2. The invention of claim 1, wherein

the detecting means includes an accelerometer for converting the mechanical movements of the patient to an electrical signal whose frequency and amplitude vary with the rapidity and intensity of the detected movements, and

the discriminating means includes means for selectively limiting said electrical signal to appreciable amplitude values in a preselected frequency range below 4 Hz.

3. The invention of claim 2, wherein

the sampling means includes

means for detecting amplitude maxima and minima of said electrical signal in said preselected frequency range in each of said successive predetermined time intervals,

means for calculating the difference in value between said maxima and minima in each said interval, and

means for determining from said difference the approximate frequency of the detected movements arising from physical exercise.

4. The invention of claim 3, wherein

the sampling means includes means for examining said predetermined time intervals at a relatively low sampling rate to conserve energy in said pacemaker.

5. The invention of claim 3, wherein

each said time interval is about 300 ms long.

6. The invention of claim 3, wherein

the determining means averages multiple ones of the difference values on a first-in, first-out basis.

7. A variable rate pacemaker responsive to patient exercise, comprising

motion sensing means for sensing physical activity of the patient and producing an electrical signal having amplitude maximum and minimum values representative of the repetitions and intensity of said physical activity,

means for detecting said amplitude maximum and minimum values of said electrical signal in each interval of a train of predetermined equal intervals of time, and

means for comparing the difference between the amplitude maximum and minimum values in different ones of said intervals of time to determine the relative repetitions of said physical activity in the compared intervals, for use in controlling the rate of said pacemaker.

8. The invention of claim 7, wherein

each of said time intervals is selected to be shorter than the likely shortest interval between repetitions of said physical activity.

9. The invention of claim 8, wherein

each said time interval is about 300 milliseconds.

10. The invention of claim 7, wherein

the comparing means averages multiple ones of the difference values on a first-in, first-out basis.

11. A process for controlling the heart rate of a patient by artificial stimulation of the heart at a variable rate according to patient exercise, comprising the steps of

detecting movements of the patient,

discriminating between those of the detected movements arising from physical exercise by the patient and other detected movements of the patient, and

scanning the detected movements arising from physical exercise in successive preselected equal intervals of time to assess from amplitude maxima and minima therein the relative rapidity of the physical exercise from one interval to the next, to adjust the stimulation rate according to that relative rapidity.

12. The process of claim 11, wherein

said time intervals are preselected to be less than the amount of time likely to be occupied by a cycle of the physical exercise.

13. The process of claim 12, wherein

said time intervals are about 300 milliseconds long.

14. The process of claim 11, wherein

said scanning includes

ascertaining the difference between the amplitude maximum and the amplitude minimum in each time interval, and

continuously calculating the average of said difference over multiple ones of the time intervals on a first-in, first-out basis to determine the instantaneous frequency of the movements in the physical exercise.

15. A method for controlling the heart rate of a patient by artificial stimulation of the heart at a variable rate according to patient exercise, comprising the steps of

detecting movements of the patient representative of the exercise, and

comparing the maximum and minimum magnitudes of the detected movements in successive equal time intervals to determine therefrom the relative frequency of the physical exercise in said time intervals, for use in controlling the stimulation rate.

16. The method of claim 15, wherein

said time intervals are preselected to be shorter than the time period likely to be occupied by each repetition cycle of the physical exercise.

17. The method of claim 16, wherein

each of said time intervals is on the order of 300 milliseconds in duration.

18. The method of claim 16, wherein

said comparing includes

averaging the difference between the maximum and the minimum magnitude in each time interval over a plurality of the time intervals, and

continuously recalculating said average with each new time interval on a first-in, first-out basis to determine said relative frequency.

19. An implantable activity-sensing, rate adaptive pacemaker for use in a patient, comprising

means for detecting repetitive movements of the patient indicative of true exercise, and

means responsive to detection of such repetitive movements for comparing the maximum and minimum amplitudes of the detected movements in each of successive equal intervals of time to determine therefrom the relative frequency of the repetitions over multiple ones of said time intervals, for use in controlling the stimulation rate of the pacemaker.

20. The invention of claim 19, wherein

each of said time intervals is preselected to be shorter than the time period likely to be occupied by each repetition cycle of the physical exercise.

21. The invention of claim 20, wherein

each of said time intervals is not greater than approximately 300 milliseconds in duration.

22. The invention of claim 20, wherein

said comparing means includes

means for averaging the difference between the maximum and the minimum amplitude in each time interval over a multiplicity of the time intervals, and

means for continuously recalculating said average with each new time interval on a first-in, first-out basis to determine said relative frequency.

23. The invention of claim 19, wherein

said comparing means includes

means for averaging the difference between the maximum and the minimum amplitude in each time interval over a multiplicity of the time intervals, and

means for continuously recalculating said average with each new time interval on a first-in, first-out basis to determine said relative frequency.

24. In combination with a sensor for sensing a biological parameter of a patient indicative of the patient'"'"'s metabolic rate, a variable rate pacemaker adaptive to various hemodynamic conditions, comprising

means responsive to the sensing of said biological parameter for producing an electrical signal having amplitude and frequency content representative of changes in said biological parameter, and

means responsive to detection of only the amplitude of said electrical signal for determining therefrom both relative amplitude and frequency of said signal representative of changes in said biological parameter for use in controlling the rate of said pacemaker.

25. The invention of claim 24, wherein

the determining means includes

means for ascertaining the maximum and minimum values of the amplitude of said electrical signal in each interval of a series of predetermined equal intervals of time, and

means for comparing the difference between the amplitude maximum and minimum values in different ones of said intervals of time to obtain the relative frequency of said signal in the compared intervals.

26. The invention of claim 25, wherein

each time interval is selected to be shorter than the estimated shortest period associated with the frequency of said signal.

27. The invention of claim 25, wherein

the comparing means averages multiple ones of the difference values on a first-in, first-out basis.

28. A method for controlling the heart rate of a patient by artificial stimulation of the heart at a variable rate according to various hemodynamic conditions, comprising the steps of

detecting a biological parameter of the patient indicative of the patient'"'"'s present metabolic state,

converting the detected biological parameter to a signal having an amplitude and frequency content representative of changes in the biological parameter,

determining the frequency of said signal from only the amplitude of said signal, and

using both the amplitude of the signal and the frequency determined from the amplitude to control the patient'"'"'s heart rate.

29. The method of claim 28, wherein

said determining step includes obtaining from the signal amplitude the maximum and minimum magnitude of the detected biological parameter in successive equal time intervals to ascertain therefrom the relative frequency of the changes of the biological parameter in said time intervals.

30. The method of claim 29, wherein

said time intervals are preselected to be shorter than the shortest likely time period for any cycle of said signal frequency.

31. The method of claim 29, wherein

the obtaining step includes

averaging the difference between the maximum and the minimum magnitude in each time interval over a plurality of the time intervals, and

continuously recalculating the average with each new time interval on a first-in, first-out basis to determine the relative frequency.