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Method of packaging and sterilizing a pharmaceutical product

  • US 5,033,252 A
  • Filed: 07/30/1990
  • Issued: 07/23/1991
  • Est. Priority Date: 12/23/1987
  • Status: Expired due to Term
First Claim
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1. A method of preparing and sterilizing a pharmaceutical package comprising a squeeze-type bottle containing a selected pharmaceutical liquid product, said method including the steps of:

  • (a) filling a resilient polymeric bottle with the selected pharmaceutical product to the point that said bottle is filled to capacity so as to eliminate any residual air in the bottle or the bottle neck, said bottle formed of a material that will withstand sterilizing temperatures without deforming and with substantially no leakage of vapor through the wall thereof;

    (b) inserting a plug-type cannula adapter in the neck of each bottle while forcing out excess liquid and maintaining the bottle completely filled, said adapter being of the type used for connecting the pharmaceutical package to a cannula or other such medical apparatus;

    (c) capping the bottles with a cap and providing a seal between the inner surface of the top wall of the cap and the rim of the bottle to absorb pressures developed by expansion of said bottle and prevent deformation of the cap and bottle during subsequent sterilization, thus eliminating leakage therebetween;

    (d) forming a package by inserting said bottle into an individual blister pack formed of a prescribed polymeric material suitable for use in a sterilization procedure and sealing said blister pack along the open side thereof with a closure lid made from a non-woven textile material having the characteristics of being permeable and capable of withstanding and remaining sealed to said polymeric material during the sterilization procedure; and

    (e) sterilizing said package.

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