Retrograde delivery of pharmacologic and diagnostic agents via venous circulation
First Claim
1. A system for the retrograde delivery of fluid containing pharmacologic or diagnostic fluids to a microcirculatory system in a desired location within a patient'"'"'s body through a vein which drains the microcirculatory system comprising:
- a. a catheter having an inflatable balloon at the distal end thereof and adapted to be inserted into and advanced through a patient'"'"'s venous system to a position in the vein which drains the microcirculatory system;
b. means to inflate the balloon to a size to engage the sidewalls of the vein to thereby block the interior of the vein and prevent the fluid from flowing in the vein in the same direction as normal blood out-flow;
c. means to direct fluid containing pharmacologic or diagnostic agents through the catheter and the vein and into the microcirculatory system in a retrograde direction which is opposite to the normal blood flow therethrough;
d. means for maintaining inflation of the balloon for at least two seconds so that the fluid containing pharmacologic or diagnostic agents in the microcirculatory system for a period of time of at least two seconds and at sufficient pressure to facilitate the delivery of the fluid to the desired location and the desired performance of the pharmacologic or diagnostic agent contained therein; and
e. means to deflate the balloon at the distal end of the catheter to cause the balloon to move out of engagement with the sidewalls of the vein to allow the fluid to drain from the microcirculatory system through the vein in the direction of normal blood flow therein.
3 Assignments
0 Petitions
Accused Products
Abstract
System for the retrograde delivery of fluid containing pharmacologic or diagnostic fluids to a patient'"'"'s microcirculatory system through a vein which drains the microcirculatory system comprising a catheter having an inflatable balloon at the distal end thereof and adapted to be inserted into and advanced through a patient'"'"'s venous system to a position in the vein which drains the microcirculatory system. The balloon is inflated to block the interior of the vein and prevent the fluid from flowing in the vein in the same direction as normal blood out-flow. Fluids containing pharmacologic or diagnostic agents are introduced through the catheter and the vein and into the microcirculatory system in a retrograde direction which is opposite to the normal blood flow therethrough. The fluid is maintained in the microcirculatory system for a minimum period and at sufficient pressure to facilitate the desired performance of the pharmacologic or diagnostic agent.
182 Citations
22 Claims
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1. A system for the retrograde delivery of fluid containing pharmacologic or diagnostic fluids to a microcirculatory system in a desired location within a patient'"'"'s body through a vein which drains the microcirculatory system comprising:
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a. a catheter having an inflatable balloon at the distal end thereof and adapted to be inserted into and advanced through a patient'"'"'s venous system to a position in the vein which drains the microcirculatory system; b. means to inflate the balloon to a size to engage the sidewalls of the vein to thereby block the interior of the vein and prevent the fluid from flowing in the vein in the same direction as normal blood out-flow; c. means to direct fluid containing pharmacologic or diagnostic agents through the catheter and the vein and into the microcirculatory system in a retrograde direction which is opposite to the normal blood flow therethrough; d. means for maintaining inflation of the balloon for at least two seconds so that the fluid containing pharmacologic or diagnostic agents in the microcirculatory system for a period of time of at least two seconds and at sufficient pressure to facilitate the delivery of the fluid to the desired location and the desired performance of the pharmacologic or diagnostic agent contained therein; and e. means to deflate the balloon at the distal end of the catheter to cause the balloon to move out of engagement with the sidewalls of the vein to allow the fluid to drain from the microcirculatory system through the vein in the direction of normal blood flow therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 22)
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- 15. A coronary catheter comprising an elongated hollow tubular body having a fluid delivery conduit therein which is in fluid communication with an opening thereof at the proximal end of the catheter and one or more openings at the distal end thereof and an inflatable balloon close to the distal end thereof having, when inflated, a broad base generally planar portion extending radially from the hollow tubular body for a distance to occlude the vessel in which the balloon is positioned and having a forwardly extending generally tapered portion which tapers in the distal direction to the apex thereof.
- 20. In a system for the retroperfusion of fluid to a jeopardized, ischemic organ or area of a patient'"'"'s body which includes a catheter having an elongated hollow tubular body, means to pump fluid therethrough in a pulsatile manner with the individual pulses of fluid synchronized to occur during the heart diastole, the improvement comprising the tubular body being provided with an inflatable balloon close to the distal end thereof which, when inflated, has a broad generally planar radially extending base portion and a forwardly extending tapered portion which tapers in the distal direction to the apex thereof.
Specification