Automated preparative gas chromatograph

• US 5,034,193 A
• Filed: 02/25/1988
• Issued: 07/23/1991
• Est. Priority Date: 02/25/1988
• Status: Expired due to Term

• Current Assignee: Air Products and Chemicals Incorporated (Linde Plc)
• Original Assignee: Air Products and Chemicals Incorporated (Linde Plc)
• Inventors: Booker, John, Maroulis, Peter J., Clark, Patrick J., Byerley, Robert A., Morris, Victoria J.
• Primary Examiner(s): Kepplinger, Esther L.
• Assistant Examiner(s): Kummert, Lynn M.
• Application Number:
  US07/160,541
• Time in Patent Office: 1,244 Days
• Field of Search: 422/89, 422/90, 422/54, 422/240, 436/161, 73/23.42, 73/23.4, 73/23.35, 73/23.25, 73/25.03, 55/386, 55/67, 55/197, 285/287
• US Class Current: 422/89
• CPC Class Codes: B01D 53/025 with wetted adsorbents; Chromatography analytical chromatography G01N30/00 - G01N30/96; for liquids B01D15/08
• CPC Class Codes: G01N 2030/025 Gas chromatography
• CPC Class Codes: G01N 30/30 of temperature
• CPC Class Codes: G01N 30/6047 with supporting means; Holders
• CPC Class Codes: G01N 30/84 Preparation of the fraction to be distributed

Abstract

A preparative-scale gas chromatographic system has conduits and valves adapted for analysis and collection of low volatility effluent. An injection site is provided for alternately supplying liquid solvent for removing condensed effluent from the system when the flow of effluent is terminated. Conduits are joined within the thermal conductivity detector of the system to prevent condensation at the joint. Conduits are provided with copper jackets which are coupled to sources of thermal energy to prevent condensation within the conduits. A trap filter provides backpressure in the collection system wherein recovery of condensed effluent in the filter is facilitated by the smooth surface of the filter.

Claims

1. A gas chromatographic system having a gas chromatographic column system, a thermal conductivity detector, a first conduit coupled between the chromatographic column system and the thermal conductivity detector for providing a flow of system effluent from the chromatographic column system to the thermal conductivity detector, and a separation and collection system comprising:

a plurality of collection traps;

a waste trap;

a switching valve having a plurality of inlet and outlet ports;

a stream selection valve for selectively trapping each of the various components contained in the system effluent in each one of the plurality of collection traps;

a second conduit coupled between the switching valve and the thermal conductivity detector for providing the flow of system effluent from the thermal conductivity detector to the switching valve;

a third conduit coupled between the switching valve and the stream selection valve for providing the flow of system effluent from the switching valve to the stream selection valve;

a plurality of tubes operably coupled between each of the plurality of collection traps and the stream selection valve for respectively providing a flow of each of the selectively trapped components to a respective one of the plurality of collection traps;

a waste conduit coupled between the waste trap and the switching valve;

supply means for supplying a flushing gas from a source through one of the inlet and one of the outlet ports of the switching valve and the waste conduit to the waste trap for the prevention of the backstreaming of wastes collected in the waste trap and the contamination of the switching valve while various components of the system effluent flow through the remaining inlet and outlet ports of the switching valve to respective ones of the plurality of collection traps, said supply means including means for terminating the supply of flushing gas; and

further supply means for alternatively flushing the separation and collection system and for supplying a liquid solvent for low volatility components from a source through the switching valve, the third conduit, the stream selection valve, and the plurality of tubes to the plurality of collection traps.

2. The system of claim 1 wherein the switching valve is provided with means for connecting the further supply means for supplying liquid solvent to the waste conduit for flushing the waste conduit.

3. The system of claim 1 wherein the conduit between the switching valve and the detector is substantially surrounded with a jacket having thermal conductivity and the jacket is thermally coupled to a source of thermal energy.

4. The system of claim 1 wherein each of the plurality of respective tubes is substantially surrounded by a jacket having thermal conductivity and the jacket is thermally coupled to a source of thermal energy.

5. The system of claim 1 further comprising a system for coupling the thermal conductivity detector between the chromatographic column system and the switching valve wherein:

the first conduit is partially disposed within the detector and coupled to the chromatographic column system for receiving the system effluent;

the second conduit is partially disposed within the detector and coupled to the switching valve for providing an exit for the system effluent; and

a joint for coupling the first and second conduits within the detector for preventing heat loss at the joint.

6. The system of claim 5 wherein the joint is a solder joint.

7. The system of claim 5 further comprising a jacket having thermal conductivity substantially surrounding the second conduit and directly thermally coupled to a source of thermal energy.

8. The system of claim 7 wherein the conductivity jacket extends substantially within the thermal conductivity detector.

9. The system of claim 7 wherein the second conduit is formed of nickel and the jacket is formed of copper.