Plasma gas discharge treatment for improving the compatibility of biomaterials

• US 5,034,265 A
• Filed: 08/21/1989
• Issued: 07/23/1991
• Est. Priority Date: 08/01/1983
• Status: Expired due to Fees

• Current Assignee: Washington Research Foundation (University of Washington)
• Original Assignee: Washington Research Foundation (University of Washington)
• Inventors: Garfinkle, Andrew M., Hoffman, Allan S., Ratner, Buddy D., Hanson, Stephen R.
• Primary Examiner(s): Morgenstern, Norman
• Assistant Examiner(s): Padgett, Marianne L.
• Application Number:
  US07/398,312
• Time in Patent Office: 701 Days
• Field of Search: 427/38, 427/39, 427/40, 427/41, 427/2, 427/254, 427/253, 428/265, 428/422, 204/169, 3/1.4, 3/1.5, 3/1.7, 128/DIG. 22, 604/266, 604/408, 604/409, 604/410
• US Class Current: 442/126
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 33/0088 by grafting of a monomer onto the substrate
• CPC Class Codes: A61L 33/0094 Physical treatment, e.g. plasma treatment
• CPC Class Codes: B05D 1/62 Plasma-deposition of organic layers plasma deposition in general C23C14/00, C23C16/00
• CPC Class Codes: B05D 3/142 Pretreatment
• CPC Class Codes: C08L 27/12 containing fluorine atoms
• CPC Class Codes: Y10S 623/921 Blood vessel
• CPC Class Codes: Y10T 428/31544 Addition polymer is perhalogenated
• CPC Class Codes: Y10T 442/2549 Coating or impregnation is chemically inert or of stated nonreactance

Abstract

A method of treating articles to improve their biocompatibility is disclosed. A polymeric substrate material is positioned within a reactor vessel and exposed to plasma gas discharge in the presence of an atmosphere of an inert gas and then in the presence of an organic gas, such as a fluorinated hydrocarbon gas, which forms a thin, biocompatible surface covalently bonded to the surface of the substrate. The method is particularly useful in the treatment of vascular graft materials to produce grafts that are both thrombi- and emboli-resistant.

Claims

1. A method of making a vascular prosthesis from a woven or knit polymeric substrate material whose surface exposed to blood is treated to render the vascular prosthesis both thrombi- and emboli-resistant, comprising:

exposing the surface of the woven or knit substrate material to be exposed to blood to a radio frequency plasma gas discharge in the presence of a fluorinated hydrocarbon gas, wherein the fluorinated hydrocarbon gas forms a thin coating on the surface exposed to blood of the woven or knit polymeric substrate, said thin coating characterized as highly cross-linked, covalently bound to the woven or knit polymeric substrate material, and not changing the mechanical behavior of the woven or knit polymeric substrate material or its surface texture.

2. The method of claim 1 wherein the fluorinated hydrocarbon gas is present at a pressure of from 0.1 to 1.0 torr, and wherein the radio frequency plasma discharge energy is from 5 to 100 watts.

3. The method of claim 1 wherein the fluorinated hydrocarbon gas is tetrafluoroethylene.

4. The method of claim 1 wherein the woven polymeric substrate material is a woven or knit polyethylene terephthalate.

5. A surface modified vascular graft material whose treated surface, when exposed to blood, is both thrombi- and emboli-resistant over extended periods of time, comprising:

a woven or knit polyethylene terephthalate substrate material having a thin, covalently bonded coating on the treated surface, wherein the coating consists essentially of a highly cross-linked fluorocarbon polymer resulting from a radio frequency plasma discharge polymerization process conducted in a fluorinated hydrocarbon gaseous atmosphere, and wherein the coating does not change the mechanical behavior of the woven or knit polyethylene terephthalate substrate material or its surface texture.

6. The surface modified vascular graft material of claim 5 wherein the fluorinated hydrocarbon gaseous atmosphere consists of tetrafluoroethylene.

7. The surface modified vascular graft material of claim 5 wherein the fluorinated hydrocarbon gaseous atmosphere has a pressure in the reactor vessel from 0.1 to 1.0 torr, and wherein the electric glow discharge polymerization process uses a frequency energy range of from 5 to 50 watts.

8. A method for making a surface modified woven or knit substrate material characterized by having a coated surface, when exposed to blood, is both thrombi- and emboli-resistant over extended periods of time, comprising:

exposing a surface of the woven or knit substrate material to a plasma gas discharge in the presence of an inert gas to etch and activate the surface of the woven substrate; and

exposing the etched and activated surface of the woven or knit substrate to a plasma gas discharge in the presence of a fluorinated hydrocarbon gas, wherein the surface becomes coated by a thin, covalently bound fluorocarbon polymer, characterized by being highly cross-linked and by not changing the mechanical behavior of the woven or knit substrate material or its surface texture.

9. The method of claim 8 wherein the inert gas is argon and the fluorinated hydrocarbon gas is tetrafluoroethylene.

10. The method of claim 8 wherein the woven or knit substrate is a fabric of polyethylene terephthalate.