Calcium phosphate materials

• US 5,034,352 A
• Filed: 03/12/1990
• Issued: 07/23/1991
• Est. Priority Date: 06/25/1985
• Status: Expired due to Term

• Current Assignee: Lifecore Biomedical Incorporated
• Original Assignee: Lifecore Biomedical Incorporated
• Inventors: Vit, Jaroslay, Salsbury, Ronald L., Henderson, Don J.
• Primary Examiner(s): Group, Karl
• Application Number:
  US07/492,536
• Time in Patent Office: 498 Days
• Field of Search: 501/1, 501/153, 264/117, 264/121, 264/59, 264/63, 264/DIG. 51, 23/313 R, 623/16
• US Class Current: 501/1
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61K 6/17 Particle size
• CPC Class Codes: A61K 6/75 Apatite
• CPC Class Codes: A61K 6/887 Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61K 6/891 Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61K 6/898 Polysaccharides
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C04B 35/447 based on phosphates , e.g. hydroxyapatite
• CPC Class Codes: C04B 35/634 Polymers C04B35/636 takes precedence
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C08L 3/02 Starch; Degradation products thereof, e.g. dextrin
• CPC Class Codes: C08L 33/08 Homopolymers or copolymers of acrylic acid esters
• CPC Class Codes: C08L 33/10 Homopolymers or copolymers of methacrylic acid esters
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate
• CPC Class Codes: C08L 33/14 of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08L 63/00 Compositions of epoxy resins; Compositions of derivatives of epoxy resins
• CPC Class Codes: C08L 67/00 Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain of polyester-amides C08L77/12; of polyester-imides C08L79/08; Compositions of derivatives of such polymers
• CPC Class Codes: Y02P 20/582 Recycling of unreacted starting or intermediate materials

Abstract

The invention disclosed by this application relates to a novel method of processing sinterable powders into sintered ceramic products. This application also relates to novel forms of aluminum oxide, hydroxylapatite, and tricalcium phosphate ceramic products prepared in accordance with the method of this invention, as well as novel intermediate products useful to prepare the novel ceramic products of this invention.

Claims

1. Ceramic particles of a calcium phosphate material suitable as an implant or prosthesis material, said particles being sintered agglomerate particles characterized by a bulk particle density of 80-95%, a size range of between 20 and 80 mesh and a network of micropores in the individual particles sufficient to permit tissue attachment when the particles are employed as a tissue implant or prosthesis material, the pores having a maximum pore size of about 50 microns and an average pore size of about 1.5 microns.

2. Ceramic particles as in claim 1 wherein said network of micropores is comprised of micropores about 90% of which have a pore diameter below 0.3 microns.

3. Ceramic particles as in claim 1 wherein the calcium phosphate material is hydroxylapatite.

4. Ceramic particles as in claim 1 wherein the particles are in the 10-60 mesh range.

5. Ceramic particles as in claim 1 characterized by a substantially spheroidal shape.

6. Ceramic particles of a calcium phosphate material suitable as an implant or prosthesis material, said particles being sintered agglomerate particles characterized by a bulk particle density of 80-95%, a size range of between 20 and 80 mesh and a network of micropores in the individual particles sufficient to permit tissue attachment when the particles are employed as a tissue implant or prosthesis material, the pores having an average pore size of about 1.5 microns.

7. Ceramic particles as in claim 6 wherein the calcium phosphate material is hydroxylapatite.

8. Ceramic particles as in claim 6 wherein the particles are in the 10-60 mesh range.

9. Ceramic particles as in claim 6 characterized by a substantially spheroidal shape.