Contact lens disinfecting system

• US 5,035,859 A
• Filed: 11/21/1989
• Issued: 07/30/1991
• Est. Priority Date: 11/21/1989
• Status: Expired due to Fees

• Current Assignee: Novartis Ag
• Original Assignee: Schering Corporation (Merck & Co., Inc.)
• Inventors: Gu, Ben, Ward, Sharon M., Singer, Helmut K., Bliznik, Kenneth E.
• Primary Examiner(s): Warden, Robert J.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US07/439,769
• Time in Patent Office: 616 Days
• Field of Search: 422/28, 514/424, 548/543
• US Class Current: 422/28
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 43/36 five-membered rings
• CPC Class Codes: A61L 12/142 Polymeric biguanides

Abstract

Contact lenses are disinfected by utilizing an N-alkyl-2-pyrrolidone as the microbicide. The efficacy of prior art microbicides such as chlorhexidene gluconate are enhanced by the addition of the pyrrolidones of this invention. The pyrrolidones suitable for use in the practice of this invention are the C₈ -C₂₀ N-alkyl-2-pyrrolidones. Preferably the alkyl moiety is octyl, decyl or dodecyl. The pyrrolidones can be utilized in solution or made available as a water soluble tablet.

Claims

1. A method for disinfecting contact lenses which comprises contacting the lenses with an aqueous solution comprising an N-alkyl-2-pyrrolidone, where the alkyl group of the pyrrolidone is a C₈ -C₂₀ alkyl moiety.

2. The method according to claim 1 wherein the alkyl moiety is a C₈ -C₁₂ moiety.

3. The method according to claim 1 wherein the alkyl moiety is octyl, decyl or dodecyl.

4. The method according to claim 1 wherein the aqueous solution is an isotonic saline.

5. The method according to claim 1 wherein the concentration of pyrrolidone in solution is about 0.001% to about 0.2% by weight of solution.

6. The method according to claim 1 wherein an additional microbicide is included in the solution.

7. The method according to claim 6 wherein the microbicide is chlorhexidene gluconate.

8. The method according to claim 1 wherein sodium lauryl sarcosinate is included in the solution.

9. A kit for disinfecting a contact lens which comprises:

(a) a container calibrated to contain a specific amount of aqueous liquid;

(b) a cover for said container;

(c) means for holding at least one contact lens immersed in the aqueous liquid;

(d) a unit dose of a tablet comprising an N-alkyl-2-pyrrolidone, wherein said unit dose when dissolved in the specific amount of aqueous liquid causes the liquid to have a concentration of pyrrolidone of about 0.001 to about 0.2% by weight of solution.

10. The kit according to claim 9 wherein the pyrrolidone is a C₈ -C₂₀ alkyl pyrrolidone.

11. The kit according to claim 10 wherein the N-alkyl-2-pyrrolidone is a C₈ -C₁₂ alkyl pyrrolidone.

12. The kit according to claim 10 wherein the alkyl moiety is octyl, decyl or dodecyl.

13. The kit according to claim 12 wherein the unit dose of pyrrolidone includes an organic acid and a solid carbonate.

14. The kit according to claim 13 wherein the organic acid is ascorbic acid, adipic acid, anhydrous citric acid or glutaric acid.

15. The kit according to claim 13 wherein the solid carbonate is sodium carbonate, sodium bicarbonate or potassium carbonate.

16. The kit according to claim 13 wherein a container holding at least one dose of the specific amount of aqueous liquid is included.

17. The kit according to claim 16 wherein the aqueous liquid is preserved saline solution, sterile saline solution, isotonic saline, deionized water, distilled water or mixtures thereof.

18. The kit according to claim 10 wherein an additional microbicide is included.

19. The kit according to claim 9 wherein the unit dose of pyrrolidone is in the form of an effervescent powder.