Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride

• US 5,037,647 A
• Filed: 09/15/1988
• Issued: 08/06/1991
• Est. Priority Date: 09/15/1988
• Status: Expired due to Term

• Current Assignee: Alcon Research Limited (Nestle SA), Nestle SA
• Original Assignee: Alcon Laboratories Incorporated (Alcon Incorporated)
• Inventors: Helton, Danny O., Harris, R. Gregg, Luthy, Connie L., Chowhan, Masood A.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Kulkosky, Peter F.
• Application Number:
  US07/244,974
• Time in Patent Office: 1,055 Days
• Field of Search: 514/839, 514/912, 424/78, 252/174.23
• US Class Current: 424/78.04
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/2086 Hydroxy carboxylic acids-salts thereof
• CPC Class Codes: C11D 3/3723 Polyamines or polyalkyleneimines
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

Hypotonic contact lens care compositions containing a quaternary ammonium antimicrobial agent (e.g. Polyquad®) and an anionic complexing agent (e.g. citrate) are disclosed. The compositions are useful in the disinfection of hydrophilic contact lenses, particularly Group IV lenses, and in the preservation of products for treating such lenses. Methods for use of the compositions for disinfecting and preserving are also disclosed.

Claims

1. A hypotonic contact lens composition, comprising:

0.001 wt. % of a quaternary ammonium compound having an average molecular weight in the range of about 4,000 to 7,000, said compound having the formula ##STR3## about 0.021 wt. % citric acid monohydrate, 0.56 wt. % sodium citrate dihydrate, 0.05 wt. % edetate disodium, 0.516 wt. % sodium chloride;

the composition having an osmolality of about 220 to 230 mOsm/kg.

2. A method of disinfecting a hydrophilic contact lens which comprises applying the composition of claim 1 to the lens.