Multiple-echo angiography with enhanced signal-to-noise ratio

• US 5,038,784 A
• Filed: 06/25/1990
• Issued: 08/13/1991
• Est. Priority Date: 02/11/1987
• Status: Expired due to Fees

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Dumoulin, Charles L.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US07/543,999
• Time in Patent Office: 414 Days
• Field of Search: 128/653 A, 128/653 AF, 324/306, 324/309
• US Class Current: 600/419
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography

Abstract

Several sequences of radio-frequency and magnetic field gradients are presented for obtaining from a sample multiple response echo signals from which to obtain a plurality of independent angiograms, which can be combined or separately analyzed to provide more information than an individual angiogram, but in substantially the same amount of time as a single angiogram. For example, a series of angiograms, each with a different projection axis, can be obtained in the time required to obtain a single angiogram using a single echo method. If the view angle of each echo is the same, then the acquired angiograms can be added to enhance the signal-to-noise ratio. Another pulse sequence simultaneously obtains two or more angiograms, each sensitive to one of two orthogonal flow components of the overall blood flow; the angiograms are then added to give an angiogram which is sensitive to total flow in all directions. Multiple velocity ranges are accommodated in a fourth sequence form.

Claims

1. A method for acquiring at least one nuclear magnetic resonance (NMR) angiographic image of flowing material in at least a selected portion of a sample, comprising the steps of:

(a) immersing the sample in a main static magnetic field;

(b) nutating, in the initial part of each of a first sequence and a second sequence of a sequential pair of imaging sequences for each of a multiplicity S of regions of said selected sample portion, the spins of all nuclei of a selected species;

(c) applying a pair of alternating-polarity flow-encoding signal pulses in a first magnetic field gradient impressed upon the sample, in a first direction selected to establish one axis of the NMR angiographic projection image, to cause a resulting NMR response echo signal from the spin of a moving nucleus to differ from the NMR response each signal resulting from the spin of a substantially stationary nucleus;

each of the flow-encoding pulses in the first sequence of each pair having a polarity opposite to the polarity of the like-positioned flow-encoding pulse in the second sequence of each pair;

(d) acquiring, responsive to a readout magnetic field gradient impressed upon the sample in a second direction, substantially orthogonal to the first direction, a set of data from the NMR response echo signal evoked, from the same sample portion, in each different one of a plurality N of acquisition time intervals of the first and second sequences, and including the substeps of;

generating a dephasing pulse in the readout gradient prior to only the first of the N acquisition time intervals in each sequence;

scaling the amplitude of the single dephasing pulse to be a fixed multiple of, but of opposite polarity to, the amplitude of the first readout gradient; and

then multiplying the amplitude of each j-th one of the N readout gradients by a factor (-1) .sup.(j'"'"'1), to alternate the polarity of all readout gradients in that sequence;

(e) subtracting the data in each j-th one, where l≦

j≦

N, of the NMR response signal data that is acquired in a selected one of first and second sequences, from the data in the like-numbered j-th data set of the remaining one of the first and second sequences, to generate a j-th one of a plurality N of difference data sets from which response data obtained from stationary nuclei has been substantially removed;

(f) summing all difference data sets to obtain a set of data with an increased signal-to-noise ratio (SNR); and

(g) generating, responsive to the increased-SNR data set, at least one angiographic projection image, each lying in a plane having a preselected relationship with respect to the first and second directions.

2. The method of claim 1, wherein step (d) includes the steps of:

providing, after the (j-1)-st one and prior to each j-th one of the N readout gradients, a phase-encoding pulse in a magnetic field gradient in a selected direction substantially orthogonal to the readout gradient direction;

providing, after each j-th one and prior to each (j+1-st one of the first (N-1) readout gradients, an inverted-polarity phase-encoding pulse in the magnetic field gradient in the selected direction; and

assigning, in each pair of sequences, one of the multiplicity S of different values to the amplitudes of the phase-encoding pulses.

3. The method of claim 2, wherein step (d) further comprises the step of applying a projection-dephasing gradient signal in a third direction, substantially orthogonal to both the first and second directions, to enhance suppression of the response signals evoked from the nuclei with substantially stationary spins.

4. The method of claim 1, wherein step (b) includes the step of limiting the nutating action to a predetermined volume of the sample portion.

5. The method of claim 1, wherein the sample is a portion of a living entity having a cardiac cycle, and further including the step of gating the commencement of each sequence with respect to a designated point in the cardiac cycle of the entity.

6. A method for acquiring at least one nuclear magnetic resonance (NMR) angiographic image of flowing material in at least a selected portion of a sample, comprising the steps of:

(a) immersing the sample in a main static magnetic field;

(b) nutating, in the initial part of each of a first sequence and a second sequence of a sequential pair of imaging sequences for each of a multiplicity S of regions of said selected sample portion, the spins of all nuclei of a selected species;

(c) applying a pair of alternating-polarity flow-encoding signal pulses in a first magnetic field gradient impressed upon the sample in a first direction selected to establish one axis of the NMR angiographic projection image, to cause a resulting NMR response echo signal from the spin of a moving nucleaus to differ from the NMR response echo signal resulting from the spin of a substantially stationary nucelus;

each of the flow-encoding pulses in the first sequence of each pair having a polarity opposite to the polarity of the like-positioned flow-encoding pulse in the second sequence of each pair;

(d) acquiring, responsive to a readout magnetic field gradient impressed upon the sample in a second direction, substantially orthogonal to the first direction, and with said second direction being varied to be different in each j-th one, where l≦

j≦

N of a plurality N of response data acquisition time intervals of a sequence, with the second direction being the same in each like-numbered j-th acquisition interval of both sequences of all sequence pairs, a set of data from the NMR response echo signal evoked, from the sample portion, in each different one of the plurality N of acquisition time intervals of each of the first and second sequences, and including the steps of;

acquiring in each sequence, and for at least one value of M greater than 1 and less than N, a plurality M of response data sets, each from a different one of M echoes in the same direction in that sequence, in each of at least one different preselected second direction, and with data sets being acquired from the same set of M echoes in each sequence; and

summing the data values from all M response data sets in each sequence to obtain a single summed data set for that preselected second direction in that sequence;

(e) subtracting the summed data set from one of the first and second sequences from the summed data set from the other sequence of the sequence pair, to generate a difference data set for that pair from which response data obtained from stationary nuclei has been substantially removed; and

(f) generating for each difference data set a different angiographic image, with each image lying in a plane having a preselected relationship with respect to the first direction and to the different second direction assigned to that different image.

7. The method of claim 6, wherein step (b) includes the step of limiting the nutating action to a predetermined volume of the sample portion.

8. The method of claim 6, wherein the sample is a portion of a living entity having a cardiac cycle, and further including the step of gating the commencement of each sequence with respect to a designated point in the cardiac cycle of the entity.