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Antiprotozoan method

  • US 5,039,483 A
  • Filed: 02/08/1990
  • Issued: 08/13/1991
  • Est. Priority Date: 03/10/1987
  • Status: Expired due to Term
First Claim
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1. A method of in vitro treating blood and cellular blood products from an animal to inactivate protozoa therein which comprises first bringing said blood and cellular blood products into contact with an effective amount of a photosensitizing agent which selectively binds to cell-free protozoa and protozoan-infected cells in a container and then exposing the combination of the blood and cellular blood products and agent to visible light to photosensitize and inactivate the protozoa so that said blood and cellular blood products can be returned to an animal, said photosensitizing agent having the following formula:

  • ##STR4## in which n is 1-5, m is 1 to 4, x is oxygen (O), sulfur (S), --CR1 R2 -- or selenium (Se);

    Y is O, Sor Se, M is alkaline metal or other basic group R1 and R2 are the same or different alkyl groups of 1 to 8 carbon; and

    R3 ;

    R4, R5 and R6 are selected from hydrogen, lower alkyl groups of 1 to 5 carbons, lower alkoxy groups of 1 to 5 carbon atoms, phenyl lower alkyls;

    or R3 and R4, or R4 and R5, or R5 and R6 are part of an aromatic ring.

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