Antiprotozoan method
First Claim
1. A method of in vitro treating blood and cellular blood products from an animal to inactivate protozoa therein which comprises first bringing said blood and cellular blood products into contact with an effective amount of a photosensitizing agent which selectively binds to cell-free protozoa and protozoan-infected cells in a container and then exposing the combination of the blood and cellular blood products and agent to visible light to photosensitize and inactivate the protozoa so that said blood and cellular blood products can be returned to an animal, said photosensitizing agent having the following formula:
- ##STR4## in which n is 1-5, m is 1 to 4, x is oxygen (O), sulfur (S), --CR1 R2 -- or selenium (Se);
Y is O, Sor Se, M is alkaline metal or other basic group R1 and R2 are the same or different alkyl groups of 1 to 8 carbon; and
R3 ;
R4, R5 and R6 are selected from hydrogen, lower alkyl groups of 1 to 5 carbons, lower alkoxy groups of 1 to 5 carbon atoms, phenyl lower alkyls;
or R3 and R4, or R4 and R5, or R5 and R6 are part of an aromatic ring.
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Accused Products
Abstract
A method of treating a body fluid so as to inactivate protozoa in said fluid comprises mixing the body fluid with an effective amount of a photosensitizing agent which will bind to cell-free protozoa and/or protozoan-infected cells, and then exposing the resulting mixture to visible light to inactivate the protozoa. An apparatus for use in the method includes at least one container which contains a body fluid containing protozoa and an effective amount of a photosensitizing agent to bind to the protozoa. The apparatus has at least one wall which is permeable to visible light.
34 Citations
6 Claims
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1. A method of in vitro treating blood and cellular blood products from an animal to inactivate protozoa therein which comprises first bringing said blood and cellular blood products into contact with an effective amount of a photosensitizing agent which selectively binds to cell-free protozoa and protozoan-infected cells in a container and then exposing the combination of the blood and cellular blood products and agent to visible light to photosensitize and inactivate the protozoa so that said blood and cellular blood products can be returned to an animal, said photosensitizing agent having the following formula:
- ##STR4## in which n is 1-5, m is 1 to 4, x is oxygen (O), sulfur (S), --CR1 R2 -- or selenium (Se);
Y is O, Sor Se, M is alkaline metal or other basic group R1 and R2 are the same or different alkyl groups of 1 to 8 carbon; and
R3 ;
R4, R5 and R6 are selected from hydrogen, lower alkyl groups of 1 to 5 carbons, lower alkoxy groups of 1 to 5 carbon atoms, phenyl lower alkyls;
or R3 and R4, or R4 and R5, or R5 and R6 are part of an aromatic ring. - View Dependent Claims (2, 3, 4, 5, 6)
- ##STR4## in which n is 1-5, m is 1 to 4, x is oxygen (O), sulfur (S), --CR1 R2 -- or selenium (Se);
Specification