Automatic radioisotope filling apparatus

• US 5,039,863 A
• Filed: 11/13/1989
• Issued: 08/13/1991
• Est. Priority Date: 11/15/1988
• Status: Expired due to Fees

• Current Assignee: UBE Industries Limited (UBE Corporation)
• Original Assignee: UBE Industries Limited (UBE Corporation)
• Inventors: Tanaka, Masaaki, Matsunami, Satoshi, Matsuno, Masao
• Primary Examiner(s): Anderson, Bruce C.
• Application Number:
  US07/434,751
• Time in Patent Office: 638 Days
• Field of Search: 250/432 PD
• US Class Current: 250/432.0PD
• CPC Class Codes: G01N 1/38 Diluting, dispersing or mixing samples
• CPC Class Codes: G01T 7/02 Collecting means for receiving or storing samples to be investigated and possibly directly transporting the samples to the measuring arrangement; particularly for investigating radioactive fluids sampling, preparing specimens for investigation in general G01N1/00, G01N1/02; shielded cells or rooms structurally combined with manipulatin devices G21F; measuring of chromatographically separated samples G01N30/00 - G01N30/96

Abstract

The automatic radioisotope filling apparatus of the present invention is equipped with a radioisotope vial containing a radioisotope solution, a saline vial containing a physiological saline solution, a dilution vial to which a predetermined amount of the radioisotope solution and a predetermined amount of the physiological saline solution are to be transferred to prepare a diluted radioisotope solution, a radiation detector for measuring the radioactive intensity of the diluted radioisotope solution prepared in the dilution vial, and a plurality of label vials containing a drug to be labeled. With this apparatus, the radiation exposure which the operator undergoes can be reduced and a diluted radioisotope solution of precisely known radioactivity can be transferred to the label vials, by employing special methods in stirring the label vials, in sequentially transferring the diluted radioisotope solution to the label vials, and in transferring the radioisotope solution and the physiological saline solution to the dilution vial and the label vials.

Claims

1. An automatic radioisotope filling apparatus comprising:

a radioisotope vial containing a radioisotope solution;

a saline vial containing a physiological saline solution;

a plurality of label vials containing a drug into which a predetermined amount of the radioisotope solution or the physiological saline solution is to be provided;

a plurality of vial shields, an opening of each vial shield, accommodating each label vial, is directed obliquely upward at a side of the vial shield which is opposite an operator when stirring of each label vial has been completed; and

withdraw and transfer means for withdrawing said radioisotope solution and physiological saline solution and for transferring said solutions to said label vials.

2. An automatic radioisotope filling apparatus comprising:

a radioisotope vial containing a radioisotope solution;

a saline vial containing a physiological saline solution;

a dilution vial into which a predetermined amount of the radioisotope solution and a predetermined amount of the physiological saline solution are provided to prepare a diluted radioisotope solution;

a radiation detector for measuring the radioactive intensity of the solution in the dilution vial;

a plurality of label vials containing a drug to be labeled; and

withdraw and transfer means for withdrawing and transferring said solutions, wherein the diluted radioisotope solution preparation in the dilution vial is provided into each of the label vials containing said drug, prepared as a labeled drug, and wherein each label vial is provided with a predetermined amount of the diluted radioisotope solution and means for immediately subjecting a label vial to stirring before a next label vial is subjected to a same procedure.

3. An automatic radioisotope filling apparatus according to claim 2, wherein the stirring is effected by rotating each label vial about a lateral axis of each label vial.

4. An automatic radioisotope filling apparatus comprising:

a radioisotope generator for milking a radioisotope to produce a radioisotope solution;

a saline vial containing a physiological saline solution;

a plurality of label vials containing a drug into which a predetermined amount of the radioisotope solution or the physiological saline solution is to be provided;

a metering and transfer means for withdrawing and transferring a predetermined amount of the radioisotope solution from the radioisotope generator by suction;

a dilution vial into which a predetermined amount of the radioisotope solution and a predetermined amount of the physiological saline solution are provided to prepare a diluted radioisotope solution; and

a radiation detector for measuring radioactive intensity of the radioisotope solution transferred to the dilution vial,

wherein specific radioactivity of the radioisotope solution transferred to the dilution vial is calculated based on volume of the radioisotope solution transferred to the dilution vial, the radioactive intensity of the radioisotope solution measured by the radiation detector, an amount of drug needed and a name of a nuclide.

5. An automatic radioisotope filling apparatus according to claim 4, further comprising:

a drain vial for discharging a given amount of the radioisotope solution supplied from the radioisotope generator, wherein said given amount of the radioisotope solution supplied from the radioisotope generator is first discharged into the drain vial and then a desired amount of the radioisotope solution is metered and transferred to the dilution vial.

6. An automatic radioisotope filling apparatus according to claim 4, further comprising:

an operation control device including a timer, wherein an operation is started at a specified time or after a lapse of a specified time period.

7. An automatic radioisotope filling apparatus comprising:

a radioisotope vial containing a radioisotope solution, or a radioisotope generator for milking a radioisotope to produce a radioisotope solution;

a saline vial containing a physiological saline solution;

a syringe for withdrawing a predetermined amount of the radioisotope solution or the physiological saline solution by suction;

a dilution vial into which a measured amount of the radioisotope solution or a measured amount of the physiological saline solution is to be provided;

a plurality of label vials containing a drug into which a predetermined amount of the radioisotope solution or a predetermined amount of the physiological saline solution is to be provided; and

a tube connecting the syringe, the vials and the generator,

wherein in discharging the solution remaining in the tube, an amount of air, at least equivalent to the internal volume of a discharging section of the tube, is sucked into the syringe and then the solution remaining in the tube is discharged using the air as a buffer material.

8. An automatic radioisotope filling apparatus according to claim 7, wherein in sucking the radioisotope solution or the physiological saline solution into the syringe and discharging the solution from the syringe, the position of the syringe piston at a start of suctioning of the solution and at completion of discharging of the solution is set at a position above the syringe bottom with a certain amount of air filled up to said position.

9. An automatic radioisotope filling apparatus according to claim 7, further comprising a control means for controlling discharge of the syringe wherein in discharging the solution in the syringe, the syringe discharging the solution in the tube at a flow speed in the tube, when the solution is in the syringe, which is greater than a flow speed in the tube when the solution in the tube has been completely discharged using air as a buffer material.

10. An automatic radioisotope filling apparatus according to claim 7, further comprising a control means for controlling sucking of the syringe wherein in sucking the solution into the syringe in a state that a predetermined amount of air is in the syringe, the syringe sucking the solution into the syringe at a solution speed in the tube, from the start of suction up to a time when the solution at the syringe bottom reaches a predetermined height, which is greater than a solution speed in the tube after said time.