Apparatus and method for analysis using x-rays

• US 5,040,199 A
• Filed: 03/07/1989
• Issued: 08/13/1991
• Est. Priority Date: 07/14/1986
• Status: Expired due to Term

• Current Assignee: Hologic Incorporated
• Original Assignee: Hologic Incorporated
• Inventors: Stein, Jay A.
• Primary Examiner(s): Westin, Edward P.
• Assistant Examiner(s): Porta, David P.
• Application Number:
  US07/319,994
• Time in Patent Office: 889 Days
• Field of Search: 378/51-56, 378/110-112, 378/207, 378/62, 378/146, 378/204, 378/4, 378/16
• US Class Current: 378/56
• CPC Class Codes: A61B 6/4042 K-edge filters
• CPC Class Codes: A61B 6/482 involving multiple energy imaging
• CPC Class Codes: A61B 6/505 for diagnosis of bone
• CPC Class Codes: G01N 23/083 the radiation being X-rays
• CPC Class Codes: G01V 5/224 Multiple energy techniques using one type of radiation, e.g. X-rays of different energies
• CPC Class Codes: G21K 1/043 changing time structure of beams by mechanical means, e.g. choppers, spinning filter wheels
• CPC Class Codes: G21K 1/10 Scattering devices; Absorbing devices; Ionising radiation filters
• CPC Class Codes: H05G 1/26 Measuring, controlling or protecting measuring X-ray radiation G01T
• CPC Class Codes: H05G 1/46 Combined control of different quantities, e.g. exposure time as well as voltage or current

Abstract

An x-ray analysis apparatus with an x-ray tube which generates an x-ray beam to expose an object to be analyzed. The apparatus inserts into and removes from the x-ray beam a piece of reference material such that regions of the object are exposed both to the x-ray beam and the x-ray beam obstructed by the reference material. A detector detects x-rays passing through the object and produces an indication of the object based upon the signals produced by the exposure to the x-ray beam and upon the signals produced by the exposure to the x-ray beam obstructed by the reference material.

Claims

1. An x-ray analysis apparatus for determining the content of a material of interest within an object comprising an x-ray tube means and associated power supply which generates an x-ray beam, means to expose to the x-ray beam an object to be analyzed, means to insert into and remove from the x-ray beam a piece of reference material in the manner that all regions of the object are exposed both to the x-ray beam and to the x-ray beam obstructed by the reference material, said reference material having x-ray absorption properties substantially corresponding to those of said material of interest, detector means arranged on the opposite side of the object to detect x-rays and produce signals corresponding to the amount of x-rays transmitted through the object, and signal processing means responsive to signals from the detector means to produce an indication of the content of said material of interest in the object based upon the signals produced by the exposure to the x-ray beam and the signals produced by the exposure to the x-ray beam obstructed by the reference material.

2. The x-ray analysis apparatus of claim 1 wherein said signal processing means is responsive to distinguish, from the set of signals produced by the x-ray beam, a subset of signals which corresponds to regions of the object having a predetermined property.

3. The x-ray analysis apparatus of claim 1 wherein the means to expose the regions to the x-ray beam is a scanning means constructed to scan the beam in a pattern over the object and the means to insert the piece of reference material is constructed and arranged to cause any point of the object exposed to the unobstructed beam to lie substantially adjacent to a point exposed to the beam while obstructed by the reference material.

4. The apparatus of claim 3 in which said means to insert and remove the reference material is constructed to act on lines of scan distributed throughout the pattern of the scan.

5. The apparatus of claim 3 in which said x-ray tube means is constructed to produce a fan beam.

6. The apparatus of any of the claim 1 in which said means to insert and remove the reference material comprises a rotating carrier constructed to repeatedly carry the piece of material into and out of the beam during the scan.

7. The apparatus of any of the claims 1, 5 or 6 adapted to effectively examine the object at more than one level of x-ray energy, said means to insert into and remove reference material adapted to act upon beams of each level of x-ray energy.

8. The apparatus of claim 1 wherein said power supply comprises means for applying alternate high and low voltage levels to said x-ray tube.

9. An apparatus responsive to the absorption characteristics of an object exposed to a radiation beam of at least two different energies from an x-ray source, the apparatus including an x-ray source, a detector, and a reference system which is capable of interposing into said radiation beam substantially over the extent of the exposed area of the object a material of known absorption characteristics in a manner to produce four sets of absorption data independent of the object being examined, namely high energy without reference material interposed, high energy with reference material interposed, low energy without reference material interposed and low energy with reference material interposed, and signal processing means responsive to said four sets of data and capable of using the known absorption characteristics of said reference system and the absorption characteristics of the object as represented by x-rays reaching the detector, both with and without the presence of the reference material in the beam, to determine a characteristic of the object.

10. The apparatus of claim 9 wherein said object is a patient, said reference material comprises a piece of bone-like calibration material of predetermined properties, and said apparatus is in the form of a bone densitometer for measuring bone content in the patient,

said x-ray source comprising an x-ray tube means and associated power supply which generates an x-ray beam;

means to expose the x-ray beam to the patient,

means to repeatedly insert into and remove from the x-ray beam said piece of bone-like calibration material such that regions of the patient are exposed both to the x-ray beam and to the beam obstructed by said bone-like calibration material;

said detector arranged on the opposite side of the patient to detect x-rays and produce signals corresponding to the amount of x-rays transmitted through the patient, and

said signal processing means responsive to signals from the detector to produce a measurement of bone content based upon the signals produced by the exposure to the x-ray beam and corrected on the basis of signals produced by said exposure to the x-ray beam obstructed by said bone-like calibration material.

11. The bone densitometer of claim 10 wherein the signal processing means is responsive to data based upon x-rays passing through regions having only flesh to produce the correction.

12. The bone densitometer of claim 10 wherein the exposure is limited to an area within the outer dimensions of the patient.

13. The bone densitometer of claim 10 adapted to produce and process signals based upon passage of x-rays of respectively different energies through the patient.

14. The base densitometer of claim 13 wherein said power supply is constructed to apply alternate high and low voltage levels to said x-ray tube to produce said x-rays of different energies.

15. The bone densitometer of claim 14 wherein said x-ray beam is scanned across the patient and a control means for controlling the frequency of alternating said voltage is dependent upon the speed at which said beam is driven in scan motion and the beam width of said beam such that said control means applies alternating high and low voltage levels to the x-ray tube at a frequency sufficiently high that at least one of the high and low level exposures occurs during the short time period during which the beam traverses a distance equal to about one beam thickness.

16. The bone densitometer of claim 15 in which said beam is a fan beam, and is constructed to produce pairs of high and low voltage pulses at a rate of the order of sixty per second, said fan-beam being driven along said scan at a rate of the order of one inch per second, the fan beam having thickness of between about one and three millimeters.

17. The bone densitometer of claim 14 constructed to cause said power supply to supply alternate high and low voltage to said x-ray tube and said x-ray beam passes through said bone-like calibration material for the duration of every other high and low voltage pulse pair.

18. The bone densitometer of claim 10 wherein said beam is a scanned fan beam and said detector means comprises a linear array of integrating detector elements controlled to integrate the detected signal repeatedly over time periods that are short relative to the time required to advance the x-ray scan pattern by one beam thickness.

19. The bone densitometer of claim 10 including an analog to digital converter to convert each integrated value to a digital signal and a digital computer means for producing said measurement of bone content of the patient by processing a stream of said digital signals.

20. The bone densitometer of claim 14 wherein said beam is a scanned fan beam and said x-ray beam passes through said bone-like calibration material at least twice per every four scan lines for a period during which the fan-beam moves less than about one beam thickness and wherein said detector means comprises an integrating detector controlled to integrate the detected signal repeatedly over short time periods relative to the time required to advance said x-ray tube in its scan by one beam thickness of resolution.

21. The bone densitometer of claim 20 wherein said detector means comprises a linear array of integrating detector elements.

22. The bone densitometer of claim 10 in which the bone-like calibration material is rotated on a disc that causes said beam to periodically pass through the calibration material for a period sufficiently small that the distance traversed by the beam during the interruption is not more than about one fan beam thickness.

23. The bone densitometer of claim 22 wherein said beam is a fan beam arranged with the longitudinal dimension of its cross-section arranged substantially radially with the said disc.

24. The bone densitometer of claim 23 wherein said detector means comprises a linear array of integrating detector elements controlled to integrate the detected signal repeatedly over short time periods relative to the time required to advance said x-ray tube in its scan by one fan beam thickness of resolution.

25. The bone densitometer of claim 10 wherein said signal processing means is responsive to distinguish, from the set of signals produced by the x-ray beam, a subset of signals which corresponds to regions of the patent having only flesh, and said signal processing means being responsive to signals from said subset as the basis for producing the correction.

26. The bone densitometer of claim 10 wherein said beam is a fan beam, including a fan beam collimator to form and direct a fan beam of x-rays through a part of the patient that includes regions having bone and adjacent regions having only flesh, said x-ray tube, fan beam collimator, means to move the callibration material, and detector means driven in unison so as to scan relative to said patient, over portions of the patient having bone and adjacent portions having only flesh.

27. The bone densitometer of claim 10 further comprising:

a cone beam collimator to form and direct a cone beam of x-rays through a part of the patient that includes regions having bone and adjacent regions not having bone.

28. The bone densitometer of claim 27 wherein said detector means comprises an x-ray image intensifier tube.

29. The bone densitometer of claim 27 including an analog to digital converter to convert each integrated value to a digital signal and a digital computer means for producing said measurement of bone content of the patient by processing a stream of said digital signals.

30. The bone densitometer of claim 27 in which the bone-like calibration material is rotated into the beam on a disc oriented such that said cone beam passses through the calibration material.

31. The bone densitometer of claim 27 wherein said signal processing means is responsive to distinguish, from the set of signals produced by the x-ray beam, a subset of signals which corresponds to regions of the patent having only flesh, and said signal processing means being responsive to signals from said subset as the basis for producing the correction.

32. The bone densitometer of claim 27 in which the bone-like calibration material is inserted into and removed from said beam by means for sliding the material into and out of the cone beam.

33. The bone densitometer of claim 10 including sandwich detector means responsive to different energies in the beam.

34. The bone densitometer of claim 10 including pulse height analysis means for identifying x-rays of different energies in the beam.

35. A method of measuring bone content in a patient who is held in fixed position comprising:

generating an x-ray beam;

exposing the patient by passing the x-ray beam through portions of the patient having bone and adjacent portions having only flesh;

passing the x-ray beam through a predetermined bone-like calibration material in the course of exposing the patient such that portions of the patient are exposed both to the x-ray beam and to the beam obstructed by said predetermined bone-like calibration material;

detecting x-rays attenuated by the patient,

calibrating signals from detected x-rays using data based upon x-rays attenuated by said calibration material; and

processing signals from detected x-rays to provide a measurement of bone content in the patient.

36. The method of claim 35 wherein every region exposed to the x-rays is exposed to both rays that are attenuated by passing through said calibration material and rays that are not attenuated to effectively form respective images.

37. The method of claim 35 or 36 conducted to effectively produce respective images of the patient based upon at least two different levels of x-ray energy.

38. The method of claim 35 wherein the signal calibrating comprises selecting data based upon x-rays attenuated by said calibration material in regions adjacent to bone.

39. The method of claim 35 further comprising restraining said x-ray tube from scanning beyond the outer dimensions of the patient.

40. An x-ray bone densitometer comprising an x-ray tube means and associated power supply which generates an x-ray beams of two different energies, means to expose to the x-ray beam regions of a patient to be analyzed, means to insert into and remove from the x-ray beam a piece of bone-like calibration material of predetermined properties such that all regions of the patient are exposed to the x-ray beams of different energies and to the beams of different energies obstructed by the bone-like calibration material, detector means arranged on the opposite side of the patient to detect x-rays and produce signals corresponding to the amount of x-rays transmitted through the patient, and signal processing means responsive to signals from the detector means to produce an indication of the content of bone within the patient based upon the signals produced by the exposure to the x-ray beams and the signals produced by the exposure to the x-ray beams obstructed by the bone-like calibration material.