Method and apparatus for the measurement and medical treatment using an ultrasonic wave

• US 5,040,537 A
• Filed: 11/21/1988
• Issued: 08/20/1991
• Est. Priority Date: 11/24/1987
• Status: Expired due to Term

• Current Assignee: Hitachi, Ltd.
• Original Assignee: Hitachi, Ltd.
• Inventors: Katakura, Kageyoshi
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Zele, John D.
• Application Number:
  US07/273,570
• Time in Patent Office: 1,002 Days
• Field of Search: 128/660.05, 128/660.07, 128/661.08, 128/661.09, 128/662.02, 128/24 AA, 128/24 EL, 128/630, 128/660.03, 606/127, 606/128
• US Class Current: 600/431
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

An ultrasonic measuring apparatus and method operating as an ultrasonic echocardiograph and a doppler blood flow speed meter by creating numerous microbubbles as a contrast medium or reflector only in an intended blood vessel. The apparatus comprises an injector which injects into a vein of patient an agent which is a substance encapsulated in numerous microcapsules of several micrometer or less in diameter and distributed in a carrier liquid so that it produces microbubbles through the reaction with blood, and a shock wave transmitter which emits a shock wave with the dominant positive pressure from the body surface toward a specific blood vessel such as the root of the aorta so that only microcapsules in the specific blood vessel, among all dispersed in the whole body, are broken by the shock wave and the agent is released in the blood flow.

Claims

1. An apparatus comprising:

means for injecting into a blood vessel of a biotic body an agent including a plurality of particles having means for one of producing gas and providing medication encapsulated therein; and

means for emitting a shock wave to a predetermined blood vessel in the biotic body with a pressure to effect breaking of the particles reaching the predetermined blood vessel so as to enable release of the means for one of producing gas and providing medication in the blood flowing in the predetermined blood vessel.

2. An apparatus according to claim 1, wherein the means for one of producing gas and providing medication is a gas producing means, and further comprising measuring means for emitting an ultrasonic wave to a desired position of the biotic body and for receiving waves reflected by bubbles created in the blood flow by the gas producing means in response to the breaking of the particles.

3. An apparatus according to claim 2, wherein the biotic body includes a heart providing a heart beat, and further comprising control means for controlling the shock wave emitting means to emit the shock wave in a predetermined phase relationship with the heart beat of the biotic body.

4. An apparatus according to claim 2, wherein the measuring means includes means for B-mode imaging.

5. An apparatus according to claim 2, wherein the measuring means includes doppler blood flow meter means for measuring speed of the blood flow based upon the doppler shift of the relected wave.

6. An apparatus according to claim 2, wherein the shock wave emitting means emits a shock wave with a dominant positive pressure.

7. An apparatus according to claim 1, further comprising cardiograph means for producing a cardiogram of the biotic body, timing control means for generating a trigger signal in a predetermined phase relationship with the cardiogram provided by the cardiograph means, and the shock wave emitting means being responsive to the timing control means for emitting the shock wave in response to the trigger signal.

8. An apparatus according to claim 7, wherein the means for one of producing gas and providing medication is a gas producing means, and further comprising measuring means for emitting an ultrasonic wave to a desired position of the biotic body and for receiving reflected by bubbles created in the blood flow by the gas producing means in response to the breaking of the particles.

9. An apparatus according to claim 8, wherein the timing control means generates the trigger signal at a timing which excludes an end portion of the diastolic period of the heart.

10. An apparatus according to claim 8, wherein the cardiograph means provides an electrocardiogram, and the timing control means includes means responsive to the cardiograph means for generating the trigger signal repeatedly upon expiration of a specified delay time following a specific wave on the electrocardiogram.

11. An apparatus according to claim 10, further comprising means for varying the setting of the delay time.

12. An apparatus according to claim 10, wherein the cardiograph means includes means for displaying the electrocardiogram and for displaying a time point of emission of the shock wave by the shock wave emitting means in relation with the electrocardiogram in accordance with the trigger signal generated by the timing control means.

13. An apparatus according to claim 12, wherein the displaying means displays the time point of emission of the shock wave on the waveform of the electrocardiogram.

14. An apparatus according to claim 8, wherein the timing control means controls the measuring means to inhibit measurement by the measuring means for a predetermined period.

15. An apparatus according to claim 11, wherein the means for one of producing gas and providing medication is a medication providing means.

16. A method comprising the steps of:

injecting into a blood vessel of a biotic body an agent including a plurality of particles having means for one of producing gas and providing medication encapsulated therein; and

emitting a shock wave to a predetermined blood vessel in the biotic body with a pressure sufficient to effect breaking of the particles reaching the predetermined blood vessel so that the means for one of producing gas and providing medication is released from the particles in blood flowing in the predetermined blood vessel.

17. A method according to claim 16, wherein the means for one of producing gas and providing medication is a gas producing means, and further comprising the steps of emitting an ultrasonic wave to a desired position of the biotic body and receiving a wave reflected by bubbles created in the blood flow by the gas producing means in response to the breaking of the particles.

18. A method according to claim 17, wherein the biotic body includes a heart providing a heart beat, and further comprising the steps of controlling a shock wave emitting means to emit the shock wave in a predetermined phase relationship with the heart beat of the biotic body.

19. A method according to claim 16, further comprising the steps of producing a cardiogram of the biotic body, generating a trigger signal in a predetermined phase relationship with the cardiogram and controlling the emission of the shock wave in accordance with the trigger signal.

20. A method according to claim 19, wherein the means for one of producing gas and providing medication is a gas producing means, and further comprising the steps emitting an ultrasonic wave to a desired position of the biotic body and receiving reflected by bubbles created in the blood flow by the gas producing means in response to the breaking of the particles.

21. A method according to claim 16, wherein the means for one of producing gas and providing medication is a medication providing means, and further comprising the step of treating the biotic body in accordance with the released medication.