Device for administering fluid drugs, in particular for infusion

• US 5,041,094 A
• Filed: 05/22/1989
• Issued: 08/20/1991
• Est. Priority Date: 07/31/1987
• Status: Expired due to Fees

• Current Assignee: Societe A Responsabilite Limitee DITE Societe de Produits Pour L'Industrie La Recherche et Les Analyses de Laboratoires
• Original Assignee: Societe A Responsabilite Limitee DITE Societe de Produits Pour L'Industrie La Recherche et Les Analyses de Laboratoires
• Inventors: Guyondet, Patrick, Perego, Jean, Perego, Francois B.
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US07/350,588
• Time in Patent Office: 820 Days
• Field of Search: 604/49, 604/51, 604/52, 604/141, 604/150, 604/131, 604/118, 604/890.1, 604/143, 222/389, 222/386, 222/326, 222/327, 222/183, 222/212, 128/DIG. 12
• US Class Current: 604/143
• CPC Class Codes: A61M 2005/14506 mechanically driven, e.g. spring or clockwork
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

The invention concerns a device and a process for administering a liquid g preparation, in particular by infusion, by implantation or percutaneously, at a given flow rate for relatively long period of time, using a technique involving the retractation of an elastic membrane. More specifically, using this technique, said drug preparation is placed in a tubular reservoir (13) where it is subjected to the action of at least one movable wall (112, 112a). The movable wall is displaced by the pressure of a hydraulic fluid (10), the entry of which is controlled by a capillary tube (4) fed with hydraulic fluid (10) under pressure by a hydraulic accumulator subject to the thrust of a previously dilated retractable elastic membrane (8).

Claims

1. A method for the administration of a liquid medicinal preparation comprising the steps of:

(a) providing a device for the continuous administration of a liquid medicinal preparation, said device having a body and a reservoir disposed in the body, and an elastic membrane surrounding at least a portion of the body;

(b) dilating the membrane by inserting fluid into the membrane;

(c) placing a medicinal preparation in said reservior;

(d) forcing the fluid through a capillary duct and onto a moving wall disposed in said reservoir by retracting the elastic membrane to administer the medicinal preparation from the reservoir.

2. The method according to claim 1, wherein the flow of the medicinal preparation to be administered is regulated by the diameter of the capillary duct (4) and the viscosity of the hydraulic fluid.

3. The method according to claim 1 or claim 2, wherein the hydraulic fluid (10) can be recycled.

4. The method according to claim 1 or claim 2, wherein the hydraulic fluid (10) is selected from the group consisting of liquid media, especially water, saline solutions, oils, polyalkylene glycols, silicones and mixtures thereof.

5. The method according to claim 1 or claim 2, wherein the total volume of hydraulic fluid to be introduced is substantially equal to or slightly greater than the volume of medicinal preparation to be administered.

18. A method according to claim 1, further comprising the step of forcing the fluid into and through a duct by retracting the membrane, thereby controlling the flow of fluid into the moving wall.

6. A device for the continuous administration of a liquid medicinal preparation, comprising:

(a) a cylindrical body having a recess hollowed out of the cylindrical body and open to the outside, the recess running along a longitudinal axis of the cylindrical body;

(b) a reservoir having an administration site, the reservoir being disposed in the recess;

(c) a retractable elastic membrane being fixed in a lock-tight manner to at least a portion of an outer surface of the cylindrical body;

(d) a hydraulic accumulator which is driven by the elastic membrane and which comprises a hydraulic fluid which can be accommodated in a space, the space being situated between the elastic membrane which has been dilated by insertion of the fluid and an outer surface of the cylindrical body;

(e) a capillary duct connected to the accumulator and supplied with the fluid by the accumulator;

(f) a piston located downstream of the capillary duct and driven by the fluid coming from the capillary duct, the piston providing for a continuous transfer of the medicinal preparation contained in the reservoir through the administration site.

7. The device according to claim 6, further comprising:

a channel located in a bottom of the recess, the channel being supplied with the hydraulic fluid from the capillary duct, wherein said piston is situated in the recess, the piston being capable of moving axially inside the recess, the piston further comprising a first face driven by the fluid coming from the channel and a second face which provides for a continuous transfer of the medicinal preparation through the administration site, and wherein the reservoir is tubular.

8. The device according to claim 7;

wherein the piston is capable of sliding inside the reservoir.

9. The device according to claim 7, wherein the reservoir has an integral thrust system, the thrust system being capable of sliding inside the reservoir and being at least partially housed inside the recess, the thrust system being driven by a pressure from the hydraulic fluid which is exerted on the first face of the piston.

10. The device according to claim 9, wherein the reservoir is disposed in a syringe, the medicinal preparation being driven by the pressure of the hydraulic fluid exerted on the first face of the piston, said pressure being transmitted via a plunger actuated by the second face of the piston.

11. The device according to claim 10, further comprising:

a second piston capable of sliding inside the reservoir, the second piston being driven by the plunger;

a fixing system joined to the outside opening of the recess, the fixing system integrally connecting the reservoir to the cylindrical body.

12. The device according to claim 7, further comprising a hollow needle which extends over at least a part of the channel in a lock-tight manner, the needle having a taper at one end which extends inside the recess, the needle supplying the first face of the piston with hydraulic fluid and also fixedly connecting the reservoir to the cylindrical body.

13. The device according to claim 12, further comprising a stopper fixedly connecting the needle to the cylindrical body, the stopper blocking the reservoir on a side opposite the administration site, the needle passing through the stopper in a lock-tight manner, the stopper being housed over at least a portion of its thickness in the interior of the reservoir and located upstream of the piston, wherein the piston is capable of sliding in a locktight manner inside the reservoir and wherein the tapered point of the needle extends through the stopper proximate the first face of the piston.

14. The device according to claim 7 further comprising a part within which the capillary duct is made, the duct having a uniform diameter, the part being located in a lock-tight manner in a second recess in the cylindrical body, the second recess being located between the accumulator and the channel.

15. The device according to claim 7, wherein at least a second recess which is open to the outside is formed in said cylindrical body, the second recess being opposite the longitudinal recess, and further comprising means for charging the hydraulic accumulator, the means for charging being housed within the second recess.

16. The device according to claim 6 or claim 19, wherein the elastic membrane is constructed in the form of one of a sleeve and a cap placed around the cylindrical body, the diameter of the sleeve in an unstretched state being less than that of a diameter of the outer surface of the cylindrical body and a ratio R:

##EQU2## of the membrane being between 0.05 and 0.10.

17. The device according to claim 6 or claim 19, wherein the elastic membrane is constructed in the form of one of a cap and a sleeve placed around the cylindrical body, the diameter of the cap in an unstretched state being less than that of a diameter of the outer surface of the cylindrical body and a ratio R:

##EQU3## of the membrane being between 0.06 and 0.09.