Physiologically-active substance fixed to a thin fiber carrier with an alkylene oxide chain

• US 5,043,278 A
• Filed: 07/06/1990
• Issued: 08/27/1991
• Est. Priority Date: 03/28/1986
• Status: Expired due to Fees

• Current Assignee: Toray Industries Incorporated
• Original Assignee: Toray Industries Incorporated
• Inventors: Mori, Yuichi, Nagaoka, Shoji, Kurumatani, Hajimu
• Primary Examiner(s): Naff, David M.
• Application Number:
  US07/549,251
• Time in Patent Office: 417 Days
• Field of Search: 435/174, 435/177, 435/188, 435/181, 530/812, 530/813, 530/816, 436/520, 436/530, 436/532
• US Class Current: 435/181
• CPC Class Codes: A61L 33/0029 using an intermediate layer of polymer
• CPC Class Codes: B01J 20/262 obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds per se C08G
• CPC Class Codes: B01J 20/264 derived from different types of monomers, e.g. linear or branched copolymers, block copolymers, graft copolymers
• CPC Class Codes: B01J 20/265 modified or post-treated polymers polymer carriers or substrates subjected to further impregnating or coating B01J20/3208
• CPC Class Codes: B01J 20/28004 Sorbent size or size distribution, e.g. particle size
• CPC Class Codes: B01J 20/28023 Fibres or filaments fibres or filaments in the form of membranes B01J20/28038; B01J20/28007 takes precedence
• CPC Class Codes: B01J 20/289 bonded via a spacer
• CPC Class Codes: B01J 20/321 consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3212 consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3272 Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3276 Copolymers
• CPC Class Codes: B01J 2220/54 Sorbents specially adapted for analytical or investigative chromatography
• CPC Class Codes: C12N 11/082 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: C12N 11/087 Acrylic polymers
• CPC Class Codes: C12N 11/089 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: G01N 33/54353 with ligand attached to the carrier via a chemical coupling agent coatings G01N33/54393
• CPC Class Codes: G01N 33/545 Synthetic resin
• CPC Class Codes: Y10S 530/812 Peptides or proteins is immobilized on, or in, an organic carrier
• CPC Class Codes: Y10S 530/813 Carrier is a saccharide
• CPC Class Codes: Y10S 530/816 Attached to the carrier via a bridging agent

Abstract

Fixation of a physiologically active substance on a carrier through an alkylene oxide chain allows the physioactive function of the substance to be retained to a high degree. The fixed physiologically-active substances are useful for separation and purification of materials. The carrier is preferably a thin fiber of 1.0 denier or less, and may be formed from a polymer. The alkylene oxide chain has an amino or epoxy group at one end which bonds to the carrier and a functional group at the other end which bonds to a physiologically-active substance.

The carrier is preferably a thin fiber of 1.0 denier or less, and may be formed from a polymer. The alkylene oxide chain has an amino or epoxy group at one end which bonds to the carrier and a functional group at the other end which bonds to a physiologically-active substance.

Claims

1. A fixing material for use with physiologically active substances, said fixing material consisting essentially of an alkylene oxide chain which is bonded at one end to a water-insoluble carrier in the form of a thin fiber of 1.0 denier or less, and said alkylene oxide chain having an amino or oxy group at said one end capable of bonding with said carrier and a functional group at the other end capable of reacting with the physiologically active substances, wherein the alkylene oxide is a polymer having the formula:

##STR3## wherein l is an integer of value in the range from 2 to 100 inclusive; and

m and n are 0 or a positive integer; and

##EQU2##

2. A fixing material for use with physiologically active substances according to claim 1, wherein both m and n are 0 (zero).

3. A fixing material for use with physiologically active substance according to claim 1, wherein the functional group is selected from the group consisting of amino, carboxyl, epoxy, hydroxy, carbodiimide, aldehyde, isocyanate, and imidazole groups.

4. The fixing material defined in claim 1, wherein said thin fiber is a composite sea island fiber having in cross section at least one island surrounded by a sea.

6. A fixed physiologically-active substance according to claim 1, wherein both m and n are 0 (zero).

5. A fixed physiologically-active substance consisting essentially of a physiologically active substance bonded to a water-insoluble carrier in the form of a thin fiber of 1.0 denier or less, and is bonded through an alkylene-oxide chain having an amino or oxy group at one end, capable of bonding with said carrier and a functional group at the other end capable of reacting with the physiologically-active substance, wherein the alkylene oxide chain is a polymer having the formula:

##STR4## wherein l is an integer of value in he range from 2 to 100 inclusive; and

m and n are 0 or a positive integer; and

##EQU3## said physiologically-active substance and said alkylene-oxide chain being bonded by a covalent bond.

7. The fixed physiologically-active substance defined in claim 5, wherein said thin fiber is a composite sea island fiber having in cross section at least one island surrounded by a sea.