Blood gas monitoring sensors

• US 5,047,208 A
• Filed: 02/23/1989
• Issued: 09/10/1991
• Est. Priority Date: 02/23/1989
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Schweitzer, Jeffrey A., Proctor, Keith J.
• Primary Examiner(s): Johnston, Jill
• Application Number:
  US07/314,615
• Time in Patent Office: 929 Days
• Field of Search: 422/57, 422/58, 422/82.06, 422/82.07, 422/82.08, 128/634, 356/39, 356/412, 436/68, 436/133, 350/96.29
• US Class Current: 422/402
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G01N 21/80 Indicating pH value
• CPC Class Codes: G01N 33/84 involving inorganic compounds or pH
• CPC Class Codes: Y10T 436/204998 Inorganic carbon compounds

Abstract

Colorimetric, fiber optic sensors for measuring pH, PCO₂ and/or other chemical parameters of the blood. The sensors are fabricated using a single optical fiber, which is provided with a chamber at its distal end containing a pH sensitive dye. Located distal to the chamber is a white reflective surface located within 0.04" from the end of the optical fiber, which enhances the performance of the sensor.

Claims

1. Colorimetric sensor for measurement of the amount of a chemical constituent dissolved in a fluid, comprising:

a chamber containing a colorimetric dye means for changing light absorption characteristics in response to changes in the amount of said chemical constituent, for indicating the amount of said chemical constituent;

fiber optic means having a proximal end and a distal end for delivering light from the light source to said chamber and for carrying light reflected from said chamber to a means for monitoring light intensity, the distal end of said fiber optic means coupled to said chamber and exposed to said colorimetric dye means; and

reflective means distal to said dye means for reflecting light delivered to said chamber by said fiber optic means, said reflective means comprising a white reflective surface, perpendicular to the axis of said fiber optic means and spaced no more than about 0.004" from the distal end of said fiber optic means.

2. A sensor as in claim 1 wherein said chemical constituent comprises the pH of said fluid, and wherein said colorimetric dye means changes light absorption characteristics in response to changes to pH of said fluid.

3. A sensor according to claim 1 wherein said chemical constituent comprises dissolved carbon dioxide, and wherein said colorimetric dye means changes absorption characteristics in response to changes in the amount of dissolved carbon dioxide in said fluid.

4. A sensor according to claim 1 wherein said chamber further comprises a wall permeable to said fluid.

5. A sensor according to claim 1 or claim 2 wherein said chamber further comprises a fluid permeable outer wall, impermeable to said colorimetric dye means.

6. A sensor according to claim 1 or claim 3 wherein said chamber further comprises an outer wall permeable to said chemical constituent, but impermeable to said colorimetric dye means.

7. A sensor according to claim 1 wherein said fiber optic means comprises a single optical fiber.

8. A sensor according to claim 7 wherein said chamber of said sensor comprises a tubular semipermeable membrane, mounted around the end of said optical fiber, and wherein said reflective surface of said reflective means is mounted within the distal end of said tubular membrane, distal to said colorimetric dye means.

9. A sensor according to claim 1 wherein said reflective means comprises an epoxy base adhesive with titanium dioxide as a coloring agent.

10. A sensor according to claim 1 or claim 2 wherein said colorimetric dye means comprises phenol red bound to a polymeric substrate, and wherein said dye chamber comprises a fluid permeable outer wall.

11. A sensor according to claim 1 or claim 3 wherein said colorimetric dye means comprises phenol red dissolved in a solution of sodium bicarbonate, and wherein said chamber comprises an outer wall permeable to dissolve gases including carbon dioxide, but impermeable to the dissolved ionic substances.

12. Colorimetric sensor for measurement of the amount of a chemical constituent dissolved in a fluid, comprising:

a chamber containing a colorimetric dye means for changing light absorption characteristics in response to changes in the amount of said chemical constituent, said chamber comprising a tubular semipermeable membrane having a proximal end and a distal end and containing said colorimetric dye means;

fiber optic means having a proximal end and a distal end for delivering light from the light source to said chamber and for carrying light reflected from said chamber to a means for monitoring light intensity, the distal end of said fiber optic means located within said tubular membrane and sealed to said tubular membrane, the distal end of said fiber optic means exposed to said colorimetric dye means; and

a plug of reflective adhesive, located within the distal end of said tubular membrane and sealing to the distal end of said tubular membrane, and located distal to said colorimetric dye means.

13. A sensor according to claim 12 wherein said adhesive plus is white in color and spaced from the distal end of said fiber optic means no more than about 0.004".

14. A sensor according to claim 12 or claim 13 wherein said plug of adhesive comprises an epoxy based adhesive.