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Mucoadhesive carrier for delivery of therapeutical agent

  • US 5,047,244 A
  • Filed: 06/03/1988
  • Issued: 09/10/1991
  • Est. Priority Date: 06/03/1988
  • Status: Expired due to Term
First Claim
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1. A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face;

  • said therapeutic agent being dehydroepiandrosterone, said polymer being polyethylene glycol having a number average molecular weight of about 4,000, and the weight ratio of dehydroepiandrosterone to said polyethylene glycol being about 1;

    4, respectively.

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